Agenus (AGEN) vs Bicycle Therapeutics (BCYC)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 8, 2026.
Summary
Agenus (AGEN) has outperformed Bicycle Therapeutics (BCYC) over the past year, gaining 80.8% versus a loss of 53.9%. Over five years, AGEN leads with a -92.8% price change compared with -93.6% for BCYC. Agenus is the larger company by market cap ($340.5 million vs $266.7 million), about 1.3 times the size.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | AGEN | BCYC |
|---|---|---|
| Share price | $7.54 | $3.81 |
| Market cap | $340.52M | $266.67M |
| 1-day change | -0.40% | +2.14% |
| YTD return | +140.13% | -46.19% |
| 1-year return | +80.82% | -53.87% |
| 5-year return | -92.77% | -93.57% |
| P/E ratio (TTM) | 2.98 | — |
| EPS (TTM) | $2.53 | $-2.73 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| 52-week high | $10.31 | $9.10 |
| 52-week low | $2.71 | $3.33 |
| Distance from 52-week high | -26.87% | -58.13% |
| Analyst consensus | strong_buy | none |
| Avg. price target upside | +249.20% | +149.34% |
| Average volume | 4.26M | 387.29K |
| Shares outstanding | 45.16M | 50.55M |
| Employees | 81 | 288 |
| Sector | Healthcare | Healthcare |
| Industry | Biotechnology | Biotechnology |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- AGEN has outperformed BCYC by 134.7 percentage points over the past year.
About Agenus
AGEN stock →Agenus Inc., a clinical-stage biotechnology company, discovers and develops immunotherapies for cancer and infectious diseases in the United States and internationally. It offers Retrocyte Display, an antibody expression platform for the identification of fully human and humanized monoclonal antibodies; and display technologies.
Healthcare · Biotechnology · 81 employees
About Bicycle Therapeutics
BCYC stock →Bicycle Therapeutics plc, a clinical-stage pharmaceutical company, develops a class of medicines for diseases that are underserved by existing therapeutics in the United States and the United Kingdom. The company's products pipeline include zelenectide pevedotin, a bicycle toxin conjugate (BTC), which is in phase II clinical trials for the treatment of high nectin-4 expressing tumors; nuzefatide pevedotin (EphA2), a BTC that is in phase I/II clinical trials to treat Ephrin type A receptor 2 expressing tumor; BT7480, a Bicycle tumor-targeted immune cell agonist molecule, which is in phase I/II targeting nectin-4 and agonizing CD137; and BT1702, a theranostic BRC molecule targeting MT1-MMP for which IND-enabling activities are ongoing.
Healthcare · Biotechnology · 288 employees
AGEN vs BCYC FAQ
Which is bigger, Agenus or Bicycle Therapeutics?
Agenus (AGEN) is larger, with a market capitalization of $340.52M compared with $266.67M for Bicycle Therapeutics (BCYC).
Which stock has performed better over the past year, AGEN or BCYC?
AGEN returned +80.82% over the past 12 months, compared with -53.87% for BCYC (price return, excluding dividends). Past performance does not predict future results.
Are Agenus and Bicycle Therapeutics in the same industry?
Yes. Both are classified in the Biotechnology industry within the Healthcare sector.