Alnylam Pharmaceuticals (ALNY) vs BeOne Medicines (ONC)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 8, 2026.
Summary
BeOne Medicines (ONC) has outperformed Alnylam Pharmaceuticals (ALNY) over the past year, gaining 6.6% versus a loss of 51.2%. Over five years, ALNY leads with a +7.6% price change compared with +1.6% for ONC. BeOne Medicines is the larger company by market cap ($39.83 billion vs $30.04 billion), about 1.3 times the size, while Alnylam Pharmaceuticals is growing revenue faster (+65.2% vs +40.2%).
On valuation, Alnylam Pharmaceuticals trades at a lower forward P/E (18.1x vs 34.2x for BeOne Medicines). Alnylam Pharmaceuticals converts more of its revenue into profit, with a net margin of 8.4% versus 5.4%.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | ALNY | ONC |
|---|---|---|
| Share price | $224.53 | $350.13 |
| Market cap | $30.04B | $39.83B |
| 1-day change | +0.05% | -3.82% |
| YTD return | -43.57% | +19.82% |
| 1-year return | -51.17% | +6.56% |
| 5-year return | +7.60% | +1.56% |
| P/E ratio (TTM) | 37.86 | 62.64 |
| Forward P/E | 18.07 | 34.15 |
| EPS (TTM) | $5.93 | $5.59 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| Revenue (latest FY) | $3.71B | $5.34B |
| Revenue growth (YoY) | +65.19% | +40.23% |
| Net income (latest FY) | $313.75M | $286.93M |
| Gross margin | 81.77% | 87.49% |
| Operating margin | 13.51% | 8.37% |
| Net margin | 8.45% | 5.37% |
| 52-week high | $495.55 | $385.22 |
| 52-week low | $197.81 | $253.95 |
| Distance from 52-week high | -54.69% | -9.11% |
| Analyst consensus | buy | strong_buy |
| Avg. price target upside | +65.29% | +24.30% |
| Average volume | 1.78M | 388.88K |
| Shares outstanding | 133.81M | 104.92M |
| Employees | 2,500 | 12,000 |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- ONC has outperformed ALNY by 57.7 percentage points over the past year.
- BeOne Medicines trades at a higher earnings multiple (62.6x vs 37.9x trailing P/E).
- Alnylam Pharmaceuticals grew revenue faster in its latest fiscal year (+65.19% vs +40.23%).
About Alnylam Pharmaceuticals
ALNY stock →Alnylam Pharmaceuticals, Inc. discovers, develops, manufactures, and commercializes therapeutics based on ribonucleic acid interference in the United States, Europe, and internationally.
Health Care · Biotechnology: Pharmaceutical Preparations · 2,500 employees
About BeOne Medicines
ONC stock →BeOne Medicines AG, an oncology company, engages in discovering and developing various treatments for cancer patients in the United States, China, Europe, and internationally. The company's commercial stage products include BRUKINSA, a small molecule inhibitor of Bruton's Tyrosine Kinase (BTK) for the treatment of various blood cancers; TEVIMBRA, an anti-PD-1 antibody immunotherapy for the treatment of various solid tumor and blood cancers; SYLVANT for the treatment of adult patients with multicentric castleman disease; BAITUOWEI for patients with BC in premenopausal and perimenopausal women, and cancer; and PARTRUVIX for the treatment of various solid tumors.
Health Care · Biotechnology: Pharmaceutical Preparations · 12,000 employees
ALNY vs ONC FAQ
Which is bigger, Alnylam Pharmaceuticals or BeOne Medicines?
BeOne Medicines (ONC) is larger, with a market capitalization of $39.83B compared with $30.04B for Alnylam Pharmaceuticals (ALNY).
Which stock has performed better over the past year, ALNY or ONC?
ONC returned +6.56% over the past 12 months, compared with -51.17% for ALNY (price return, excluding dividends). Past performance does not predict future results.
Which has the lower P/E ratio, ALNY or ONC?
ALNY has the lower trailing P/E at 37.9, versus 62.6 for ONC. A lower P/E is not by itself a sign of a better investment; it can reflect slower expected growth or higher risk.
Are Alnylam Pharmaceuticals and BeOne Medicines in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.