Amphastar Pharmaceuticals (AMPH) vs OPKO Health (OPK)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 8, 2026.
Summary
Amphastar Pharmaceuticals (AMPH) has outperformed OPKO Health (OPK) over the past year, losing 1.1% versus a loss of 9.7%. Over five years, AMPH leads with a +33.6% price change compared with -62.6% for OPK. Amphastar Pharmaceuticals is the larger company by market cap ($1.09 billion vs $1.04 billion), about 1.0 times the size.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | AMPH | OPK |
|---|---|---|
| Share price | $25.54 | $1.39 |
| Market cap | $1.09B | $1.04B |
| 1-day change | -1.43% | -4.79% |
| YTD return | -4.63% | +10.32% |
| 1-year return | -1.12% | -9.74% |
| 5-year return | +33.65% | -62.63% |
| P/E ratio (TTM) | 15.11 | — |
| Forward P/E | 8.03 | — |
| EPS (TTM) | $1.69 | $-0.09 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| 52-week high | $29.52 | $1.75 |
| 52-week low | $16.65 | $0.98 |
| Distance from 52-week high | -13.48% | -20.57% |
| Analyst consensus | none | none |
| Avg. price target upside | -11.90% | +215.11% |
| Average volume | 472.61K | 3.35M |
| Shares outstanding | 42.54M | 746.33M |
| Employees | 1,976 | 2,275 |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
About Amphastar Pharmaceuticals
AMPH stock →Amphastar Pharmaceuticals, Inc., a bio-pharmaceutical company, develops, manufactures, markets, and sells generic and proprietary injectable, inhalation, and intranasal products in the United States, China, and France. It offers BAQSIMI, a dry nasal spray used in an emergency for the treatment of severe hypoglycemia; Primatene MIST, an epinephrine inhalation product for the temporary relief of mild symptoms of intermittent asthma; Glucagon for injection emergency kit; Enoxaparin, an injectable form of low molecular weight heparin for the prevention and treatment of deep vein thrombosis; and REXTOVY and Naloxone for opioid overdose.
Health Care · Biotechnology: Pharmaceutical Preparations · 1,976 employees
About OPKO Health
OPK stock →OPKO Health, Inc. operates as a healthcare company, in the United States, Ireland, Chile, Spain, Israel, Mexico, and internationally.
Health Care · Biotechnology: Pharmaceutical Preparations · 2,275 employees
AMPH vs OPK FAQ
Which is bigger, Amphastar Pharmaceuticals or OPKO Health?
Amphastar Pharmaceuticals (AMPH) is larger, with a market capitalization of $1.09B compared with $1.04B for OPKO Health (OPK).
Which stock has performed better over the past year, AMPH or OPK?
AMPH returned -1.12% over the past 12 months, compared with -9.74% for OPK (price return, excluding dividends). Past performance does not predict future results.
Are Amphastar Pharmaceuticals and OPKO Health in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.