BioMarin Pharmaceutical (BMRN) vs Madrigal Pharmaceuticals (MDGL)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 7, 2026.
Summary
Madrigal Pharmaceuticals (MDGL) has outperformed BioMarin Pharmaceutical (BMRN) over the past year, gaining 11.8% versus a gain of 0.9%. Over five years, MDGL leads with a +466.0% price change compared with -27.3% for BMRN. Madrigal Pharmaceuticals is the larger company by market cap ($11.27 billion vs $10.69 billion), about 1.1 times the size.
On valuation, BioMarin Pharmaceutical trades at a lower forward P/E (8.3x vs 50.7x for Madrigal Pharmaceuticals). BioMarin Pharmaceutical converts more of its revenue into profit, with a net margin of 10.8% versus -30.1%.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | BMRN | MDGL |
|---|---|---|
| Share price | $55.20 | $487.72 |
| Market cap | $10.69B | $11.27B |
| 1-day change | -1.81% | -1.76% |
| YTD return | -7.12% | -16.25% |
| 1-year return | +0.91% | +11.79% |
| 5-year return | -27.26% | +466.00% |
| P/E ratio (TTM) | 149.19 | — |
| Forward P/E | 8.34 | 50.67 |
| EPS (TTM) | $0.37 | $-12.85 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| Revenue (latest FY) | $3.22B | $958.40M |
| Revenue growth (YoY) | +12.87% | +432.05% |
| Net income (latest FY) | $348.90M | $-288.28M |
| Gross margin | 77.73% | — |
| Operating margin | 12.71% | -31.31% |
| Net margin | 10.83% | -30.08% |
| 52-week high | $70.98 | $615.00 |
| 52-week low | $49.26 | $393.61 |
| Distance from 52-week high | -22.23% | -20.70% |
| Analyst consensus | buy | strong_buy |
| Avg. price target upside | +65.98% | +39.86% |
| Average volume | 2.01M | 289.84K |
| Shares outstanding | 193.57M | 23.10M |
| Employees | 3,221 | 915 |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- MDGL has outperformed BMRN by 10.9 percentage points over the past year.
- BioMarin Pharmaceutical is more profitable, keeping 10.8 cents of every revenue dollar as net income versus -30.1 cents for Madrigal Pharmaceuticals.
- Madrigal Pharmaceuticals grew revenue faster in its latest fiscal year (+432.05% vs +12.87%).
About BioMarin Pharmaceutical
BMRN stock →BioMarin Pharmaceutical Inc., a biotechnology company, engages in the development and commercialization of therapies for life-threatening rare diseases and medical conditions in the United States, Europe, Latin America, the Middle East, the Asia Pacific, and internationally. The company's products include VIMIZIM, an enzyme replacement therapy for the treatment of mucopolysaccharidosis (MPS) IV type A, a lysosomal storage disorder; VOXZOGO, a once daily injection analog of c-type natriuretic peptide (CNP) for the treatment of achondroplasia; NAGLAZYME, a recombinant form of N- acetylgalactosamine 4-sulfatase for patients with MPS VI; and PALYNZIQ, a PEGylated recombinant phenylalanine (Phe) ammonia lyase enzyme delivered through subcutaneous injection to reduce blood Phe concentrations.
Health Care · Biotechnology: Pharmaceutical Preparations · 3,221 employees
About Madrigal Pharmaceuticals
MDGL stock →Madrigal Pharmaceuticals, Inc., a biopharmaceutical company, focuses on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH) in the United States. It offers Rezdiffra, a liver-directed thyroid hormone receptor beta agonist for treating MASH.
Health Care · Biotechnology: Pharmaceutical Preparations · 915 employees
BMRN vs MDGL FAQ
Which is bigger, BioMarin Pharmaceutical or Madrigal Pharmaceuticals?
Madrigal Pharmaceuticals (MDGL) is larger, with a market capitalization of $11.27B compared with $10.69B for BioMarin Pharmaceutical (BMRN).
Which stock has performed better over the past year, BMRN or MDGL?
MDGL returned +11.79% over the past 12 months, compared with +0.91% for BMRN (price return, excluding dividends). Past performance does not predict future results.
Are BioMarin Pharmaceutical and Madrigal Pharmaceuticals in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.