iBio (IBIO) vs Spero Therapeutics (SPRO)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 8, 2026.
Summary
iBio (IBIO) has outperformed Spero Therapeutics (SPRO) over the past year, gaining 16.1% versus a loss of 45.8%. Over five years, SPRO leads with a -93.1% price change compared with -99.8% for IBIO. Spero Therapeutics is the larger company by market cap ($68.1 million vs $65.0 million), about 1.0 times the size.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | IBIO | SPRO |
|---|---|---|
| Share price | $1.01 | $1.17 |
| Market cap | $64.95M | $68.13M |
| 1-day change | -3.81% | -1.68% |
| YTD return | -47.67% | -49.79% |
| 1-year return | +16.09% | -45.83% |
| 5-year return | -99.78% | -93.13% |
| P/E ratio (TTM) | — | 8.36 |
| EPS (TTM) | $-0.32 | $0.14 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| 52-week high | $3.82 | $3.08 |
| 52-week low | $0.78 | $1.08 |
| Distance from 52-week high | -73.56% | -62.01% |
| Average volume | 704.06K | 1.21M |
| Shares outstanding | 64.31M | 58.23M |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- IBIO has outperformed SPRO by 61.9 percentage points over the past year.
IBIO vs SPRO FAQ
Which is bigger, iBio or Spero Therapeutics?
Spero Therapeutics (SPRO) is larger, with a market capitalization of $68.13M compared with $64.95M for iBio (IBIO).
Which stock has performed better over the past year, IBIO or SPRO?
IBIO returned +16.09% over the past 12 months, compared with -45.83% for SPRO (price return, excluding dividends). Past performance does not predict future results.
Are iBio and Spero Therapeutics in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.