Ionis Pharmaceuticals (IONS) vs TG Therapeutics (TGTX)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 9, 2026.
Summary
TG Therapeutics (TGTX) has outperformed Ionis Pharmaceuticals (IONS) over the past year, gaining 49.2% versus a loss of 38.1%. Over five years, TGTX leads with a +60.1% price change compared with +23.4% for IONS. TG Therapeutics is the larger company by market cap ($8.17 billion vs $7.20 billion), about 1.1 times the size.
TG Therapeutics converts more of its revenue into profit, with a net margin of 72.6% versus -40.4%.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | IONS | TGTX |
|---|---|---|
| Share price | $43.30 | $53.34 |
| Market cap | $7.20B | $8.17B |
| 1-day change | -1.95% | +0.74% |
| YTD return | -45.27% | +78.93% |
| 1-year return | -38.11% | +49.20% |
| 5-year return | +23.36% | +60.13% |
| P/E ratio (TTM) | — | 19.40 |
| Forward P/E | — | 19.70 |
| EPS (TTM) | $-3.48 | $2.75 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| Revenue (latest FY) | $943.71M | $616.29M |
| Revenue growth (YoY) | +33.83% | +87.32% |
| Net income (latest FY) | $-381.39M | $447.18M |
| Gross margin | 98.31% | 83.66% |
| Operating margin | -40.45% | 20.01% |
| Net margin | -40.41% | 72.56% |
| 52-week high | $86.74 | $59.30 |
| 52-week low | $42.63 | $26.76 |
| Distance from 52-week high | -50.08% | -10.05% |
| Analyst consensus | buy | strong_buy |
| Avg. price target upside | +93.16% | +30.69% |
| Average volume | 3.51M | 2.01M |
| Shares outstanding | 166.18M | 153.08M |
| Employees | 1,480 | 399 |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- TGTX has outperformed IONS by 87.3 percentage points over the past year.
- TG Therapeutics is more profitable, keeping 72.6 cents of every revenue dollar as net income versus -40.4 cents for Ionis Pharmaceuticals.
- TG Therapeutics grew revenue faster in its latest fiscal year (+87.32% vs +33.83%).
About Ionis Pharmaceuticals
IONS stock →Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; DAWNZERA for prophylaxis to prevent attacks of hereditary angioedema in adults; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA).
Health Care · Biotechnology: Pharmaceutical Preparations · 1,480 employees
About TG Therapeutics
TGTX stock →TG Therapeutics, Inc., a commercial stage biopharmaceutical company, focuses on the acquisition, development, and commercialization of novel treatments for B-cell mediated diseases in the United States and internationally. The company provides BRIUMVI, an anti-CD20 monoclonal antibody for the treatment of adult patients with relapsing forms of multiple sclerosis (RMS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease in adults.
Health Care · Biotechnology: Pharmaceutical Preparations · 399 employees
IONS vs TGTX FAQ
Which is bigger, Ionis Pharmaceuticals or TG Therapeutics?
TG Therapeutics (TGTX) is larger, with a market capitalization of $8.17B compared with $7.20B for Ionis Pharmaceuticals (IONS).
Which stock has performed better over the past year, IONS or TGTX?
TGTX returned +49.20% over the past 12 months, compared with -38.11% for IONS (price return, excluding dividends). Past performance does not predict future results.
Are Ionis Pharmaceuticals and TG Therapeutics in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.