Ionis Pharmaceuticals (IONS) vs Tango Therapeutics (TNGX)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 9, 2026.
Summary
Tango Therapeutics (TNGX) has outperformed Ionis Pharmaceuticals (IONS) over the past year, gaining 226.6% versus a loss of 38.1%. Over five years, TNGX leads with a +60.9% price change compared with +23.4% for IONS. Ionis Pharmaceuticals is the larger company by market cap ($7.20 billion vs $3.81 billion), about 1.9 times the size, while Tango Therapeutics is growing revenue faster (+48.3% vs +33.8%).
Ionis Pharmaceuticals converts more of its revenue into profit, with a net margin of -40.4% versus -162.9%.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | IONS | TNGX |
|---|---|---|
| Share price | $43.30 | $22.57 |
| Market cap | $7.20B | $3.81B |
| 1-day change | -1.95% | +3.39% |
| YTD return | -45.27% | +154.74% |
| 1-year return | -38.11% | +226.63% |
| 5-year return | +23.36% | +60.87% |
| EPS (TTM) | $-3.48 | $-0.85 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| Revenue (latest FY) | $943.71M | $62.38M |
| Revenue growth (YoY) | +33.83% | +48.29% |
| Net income (latest FY) | $-381.39M | $-101.59M |
| Gross margin | 98.31% | — |
| Operating margin | -40.45% | -178.39% |
| Net margin | -40.41% | -162.85% |
| 52-week high | $86.74 | $34.39 |
| 52-week low | $42.63 | $6.69 |
| Distance from 52-week high | -50.08% | -34.37% |
| Analyst consensus | buy | strong_buy |
| Avg. price target upside | +93.16% | +100.18% |
| Average volume | 3.51M | 2.65M |
| Shares outstanding | 166.18M | 168.61M |
| Employees | 1,480 | 137 |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- TNGX has outperformed IONS by 264.7 percentage points over the past year.
- Ionis Pharmaceuticals is more profitable, keeping -40.4 cents of every revenue dollar as net income versus -162.9 cents for Tango Therapeutics.
- Tango Therapeutics grew revenue faster in its latest fiscal year (+48.29% vs +33.83%).
About Ionis Pharmaceuticals
IONS stock →Ionis Pharmaceuticals, Inc., a commercial-stage biotechnology company, provides RNA-targeted medicines in the United States. The company offers TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS) and acute pancreatitis; DAWNZERA for prophylaxis to prevent attacks of hereditary angioedema in adults; WAINUA for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults; and SPINRAZA for pediatric and adult patients with spinal muscular atrophy (SMA).
Health Care · Biotechnology: Pharmaceutical Preparations · 1,480 employees
About Tango Therapeutics
TNGX stock →Tango Therapeutics, Inc., a precision oncology company, focuses on the discovery and development of drugs in defined patient populations with unmet medical need. The company develops methylthioadenosine -cooperative protein arginine methyltransferase 5 (PRMT5) inhibitors, including TNG462, which is in Phase 1/2 clinical trial for treating pancreatic and lung cancer; and TNG456, a brain-penetrant PRMT5 inhibitor for the treatment of glioblastoma.
Health Care · Biotechnology: Pharmaceutical Preparations · 137 employees
IONS vs TNGX FAQ
Which is bigger, Ionis Pharmaceuticals or Tango Therapeutics?
Ionis Pharmaceuticals (IONS) is larger, with a market capitalization of $7.20B compared with $3.81B for Tango Therapeutics (TNGX).
Which stock has performed better over the past year, IONS or TNGX?
TNGX returned +226.63% over the past 12 months, compared with -38.11% for IONS (price return, excluding dividends). Past performance does not predict future results.
Are Ionis Pharmaceuticals and Tango Therapeutics in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.