NRX Pharmaceuticals (NRXP) vs Spruce Biosciences (SPRB)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 8, 2026.
Summary
NRX Pharmaceuticals (NRXP) has outperformed Spruce Biosciences (SPRB) over the past year, losing 21.0% versus a loss of 75.7%. Over five years, NRXP leads with a -97.2% price change compared with -99.8% for SPRB. Spruce Biosciences is the larger company by market cap ($128.7 million vs $123.6 million), about 1.0 times the size.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | NRXP | SPRB |
|---|---|---|
| Share price | $2.86 | $44.77 |
| Market cap | $123.61M | $128.67M |
| 1-day change | -1.55% | +0.83% |
| YTD return | +7.01% | -49.03% |
| 1-year return | -20.98% | -75.68% |
| 5-year return | -97.17% | -99.82% |
| Forward P/E | — | 9.00 |
| EPS (TTM) | $-0.58 | $-39.12 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| 52-week high | $5.06 | $199.20 |
| 52-week low | $1.62 | $40.33 |
| Distance from 52-week high | -43.52% | -77.53% |
| Analyst consensus | strong_buy | strong_buy |
| Avg. price target upside | +1248.51% | +230.58% |
| Average volume | 867.50K | 77.75K |
| Shares outstanding | 43.30M | 2.87M |
| Employees | 29 | 22 |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- NRXP has outperformed SPRB by 54.7 percentage points over the past year.
About NRX Pharmaceuticals
NRXP stock →NRx Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, develops therapeutics for the treatment of central nervous system disorders comprising suicidal depression, post-traumatic stress disorder (PTSD), and schizophrenia in the United States. It operates through NRx and Dura segments.
Health Care · Biotechnology: Pharmaceutical Preparations · 29 employees
About Spruce Biosciences
SPRB stock →Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders.
Health Care · Biotechnology: Pharmaceutical Preparations · 22 employees
NRXP vs SPRB FAQ
Which is bigger, NRX Pharmaceuticals or Spruce Biosciences?
Spruce Biosciences (SPRB) is larger, with a market capitalization of $128.67M compared with $123.61M for NRX Pharmaceuticals (NRXP).
Which stock has performed better over the past year, NRXP or SPRB?
NRXP returned -20.98% over the past 12 months, compared with -75.68% for SPRB (price return, excluding dividends). Past performance does not predict future results.
Are NRX Pharmaceuticals and Spruce Biosciences in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.