ACADIA Pharmaceuticals (ACAD) vs Denali Therapeutics (DNLI)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 8, 2026.
Summary
Denali Therapeutics (DNLI) has outperformed ACADIA Pharmaceuticals (ACAD) over the past year, gaining 28.6% versus a loss of 8.8%. Over five years, ACAD leads with a +12.2% price change compared with -57.9% for DNLI. ACADIA Pharmaceuticals is the larger company by market cap ($3.39 billion vs $3.06 billion), about 1.1 times the size.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | ACAD | DNLI |
|---|---|---|
| Share price | $19.65 | $19.16 |
| Market cap | $3.39B | $3.06B |
| 1-day change | -0.46% | -0.62% |
| YTD return | -26.43% | +16.05% |
| 1-year return | -8.77% | +28.59% |
| 5-year return | +12.22% | -57.95% |
| P/E ratio (TTM) | 8.85 | — |
| Forward P/E | 22.12 | — |
| EPS (TTM) | $2.22 | $-2.82 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| Revenue (latest FY) | $1.07B | $0 |
| Revenue growth (YoY) | +11.87% | — |
| Net income (latest FY) | $391.00M | $-512.54M |
| Gross margin | 91.69% | — |
| Operating margin | 9.78% | — |
| Net margin | 36.49% | — |
| 52-week high | $30.96 | $27.30 |
| 52-week low | $19.46 | $13.75 |
| Distance from 52-week high | -36.53% | -29.82% |
| Analyst consensus | buy | strong_buy |
| Avg. price target upside | +63.66% | +88.20% |
| Average volume | 1.84M | 1.61M |
| Shares outstanding | 172.31M | 159.85M |
| Employees | 796 | 503 |
| Sector | Health Care | Healthcare |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- DNLI has outperformed ACAD by 37.4 percentage points over the past year.
- The two companies sit in different sectors: ACADIA Pharmaceuticals in Health Care and Denali Therapeutics in Healthcare.
About ACADIA Pharmaceuticals
ACAD stock →ACADIA Pharmaceuticals Inc., a biopharmaceutical company, focuses on the development and commercialization of medicines for neurological and rare disease in North America. The company offers NUPLAZID (pimavanserin), a selective serotonin inverse agonist/antagonist for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis; and DAYBUE, a novel synthetic analog of the amino-terminal tripeptide of insulin-like growth factor 1 to treat the symptoms of Rett syndrome by reducing neuroinflammation and supporting synaptic function.
Health Care · Biotechnology: Pharmaceutical Preparations · 796 employees
About Denali Therapeutics
DNLI stock →Denali Therapeutics Inc., a biopharmaceutical company, discovers and develops therapeutics to treat neurodegenerative and lysosomal storage diseases. The company develops Eclitasertib (SAR443122/DNL758) RIPK1 inhibitor program for peripheral inflammatory diseases; BIIB122/DNL151 LRRK2 inhibitor program for Parkinson's disease; TAK-594/DNL593 program for frontotemporal dementia-granulin; DNL126 program for MPS IIIA (Sanfilippo Syndrome A); and DNL310 Tividenofusp alfa, an enzyme replacement therapy program for MPS II (Hunter Syndrome).
Healthcare · Biotechnology · 503 employees
ACAD vs DNLI FAQ
Which is bigger, ACADIA Pharmaceuticals or Denali Therapeutics?
ACADIA Pharmaceuticals (ACAD) is larger, with a market capitalization of $3.39B compared with $3.06B for Denali Therapeutics (DNLI).
Which stock has performed better over the past year, ACAD or DNLI?
DNLI returned +28.59% over the past 12 months, compared with -8.77% for ACAD (price return, excluding dividends). Past performance does not predict future results.
Are ACADIA Pharmaceuticals and Denali Therapeutics in the same industry?
No. ACADIA Pharmaceuticals is in the Health Care sector, while Denali Therapeutics is in Healthcare.