ACADIA Pharmaceuticals (ACAD) vs Xenon Pharmaceuticals (XENE)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 8, 2026.
Summary
Xenon Pharmaceuticals (XENE) has outperformed ACADIA Pharmaceuticals (ACAD) over the past year, losing 7.0% versus a loss of 8.8%. Over five years, ACAD leads with a +12.2% price change compared with +8.2% for XENE. Xenon Pharmaceuticals is the larger company by market cap ($3.50 billion vs $3.37 billion), about 1.0 times the size.
ACADIA Pharmaceuticals converts more of its revenue into profit, with a net margin of 36.5% versus -4612.1%.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | ACAD | XENE |
|---|---|---|
| Share price | $19.58 | $36.16 |
| Market cap | $3.37B | $3.50B |
| 1-day change | -0.36% | -0.69% |
| YTD return | -26.43% | -18.76% |
| 1-year return | -8.77% | -7.02% |
| 5-year return | +12.22% | +8.17% |
| P/E ratio (TTM) | 8.78 | — |
| Forward P/E | 22.04 | — |
| EPS (TTM) | $2.23 | $-4.74 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| Revenue (latest FY) | $1.07B | $7.50M |
| Revenue growth (YoY) | +11.87% | — |
| Net income (latest FY) | $391.00M | $-345.91M |
| Gross margin | 91.69% | — |
| Operating margin | 9.78% | -4974.27% |
| Net margin | 36.49% | -4612.13% |
| 52-week high | $30.96 | $72.66 |
| 52-week low | $19.32 | $35.06 |
| Distance from 52-week high | -36.76% | -50.23% |
| Analyst consensus | buy | strong_buy |
| Avg. price target upside | +64.25% | +102.90% |
| Average volume | 1.84M | 1.43M |
| Shares outstanding | 172.31M | 96.84M |
| Employees | 796 | 358 |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- ACADIA Pharmaceuticals is more profitable, keeping 36.5 cents of every revenue dollar as net income versus -4612.1 cents for Xenon Pharmaceuticals.
About ACADIA Pharmaceuticals
ACAD stock →ACADIA Pharmaceuticals Inc., a biopharmaceutical company, focuses on the development and commercialization of medicines for neurological and rare disease in North America. The company offers NUPLAZID (pimavanserin), a selective serotonin inverse agonist/antagonist for the treatment of hallucinations and delusions associated with Parkinson's disease psychosis; and DAYBUE, a novel synthetic analog of the amino-terminal tripeptide of insulin-like growth factor 1 to treat the symptoms of Rett syndrome by reducing neuroinflammation and supporting synaptic function.
Health Care · Biotechnology: Pharmaceutical Preparations · 796 employees
About Xenon Pharmaceuticals
XENE stock →Xenon Pharmaceuticals Inc., a neuroscience-focused biopharmaceutical company, engages in the discovery, development, and delivery of therapeutics to treat patients with neurological and psychiatric disorders. Its product candidates include Azetukalner, a novel, potent Kv7 potassium channel opener which is in Phase 3 clinical development for the treatment of epilepsy, including focal onset seizures, and primary generalized tonic-clonic seizures, as well as neuropsychiatric disorders, such as major depressive disorder and bipolar depression.
Health Care · Biotechnology: Pharmaceutical Preparations · 358 employees
ACAD vs XENE FAQ
Which is bigger, ACADIA Pharmaceuticals or Xenon Pharmaceuticals?
Xenon Pharmaceuticals (XENE) is larger, with a market capitalization of $3.50B compared with $3.37B for ACADIA Pharmaceuticals (ACAD).
Which stock has performed better over the past year, ACAD or XENE?
XENE returned -7.02% over the past 12 months, compared with -8.77% for ACAD (price return, excluding dividends). Past performance does not predict future results.
Are ACADIA Pharmaceuticals and Xenon Pharmaceuticals in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.