MetaCap

Akari Therapeutics (AKTX) vs Aytu BioPharma (AYTU)

Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 9, 2026.

Summary

Aytu BioPharma (AYTU) has outperformed Akari Therapeutics (AKTX) over the past year, losing 13.5% versus a loss of 80.1%. Over five years, AYTU leads with a -96.1% price change compared with -99.4% for AKTX. Aytu BioPharma is the larger company by market cap ($22.0 million vs $19.8 million), about 1.1 times the size.

Summary generated from market data by MetaCap's automated system. Methodology

Relative performance

AKTX-80.07%AYTU-13.50%
+28%-35%-98%
Oct 8, 20251 yearOct 8, 2026
AKTX-99.37%AYTU-96.20%
+10%-47%-105%
Oct 4, 20215 yearsOct 5, 2026

Percent change in share price from the first common trading day shown; excludes dividends.

Head-to-head

AKTX versus AYTU key metrics
MetricAKTXAYTU
Share price$8.67$2.02
Market cap$19.81M$21.95M
1-day change+2.12%-1.46%
YTD return-29.67%-21.15%
1-year return-80.07%-13.50%
5-year return-99.38%-96.13%
Forward P/E—13.03
EPS (TTM)$0.00$-1.16
Dividend yield0.00%0.00%
Annual dividend$0.00$0.00
52-week high$40.00$3.07
52-week low$3.02$1.80
Distance from 52-week high-78.33%-34.20%
Analyst consensusnonestrong_buy
Avg. price target upside+194.12%+378.71%
Average volume61.08K34.22K
Shares outstanding2.29M10.87M
Employees575
SectorHealth CareHealth Care
IndustryBiotechnology: Pharmaceutical PreparationsBiotechnology: Pharmaceutical Preparations

Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.

Key differences

  • AYTU has outperformed AKTX by 66.6 percentage points over the past year.

About Akari Therapeutics

AKTX stock →

Akari Therapeutics, Plc, an oncology company, develops antibody-drug conjugates (ADC) for cancer-killing toxins. Its lead payload is PH1 to disrupt the function of spliceosomes and to trigger an immune response that leads to additional cancer cell killing.

Health Care · Biotechnology: Pharmaceutical Preparations · 5 employees

About Aytu BioPharma

AYTU stock →

Aytu BioPharma, Inc., a pharmaceutical company, focuses on commercializing novel therapeutics in the United States and internationally. The company offers prescription products for the treatment of attention deficit hyperactivity disorder (ADHD), including Adzenys XR-ODT extended-release orally disintegrating tablets for patients from six years of age and above; Cotempla XR-ODT A central nervous system stimulant indicated for the treatment of ADHD in patients 6 to 17 years of age; and Metadate CD, a central nervous system stimulant indicated for the treatment of ADHD in patients 6 to 15 years of age.

Health Care · Biotechnology: Pharmaceutical Preparations · 75 employees

AKTX vs AYTU FAQ

Which is bigger, Akari Therapeutics or Aytu BioPharma?

Aytu BioPharma (AYTU) is larger, with a market capitalization of $21.95M compared with $19.81M for Akari Therapeutics (AKTX).

Which stock has performed better over the past year, AKTX or AYTU?

AYTU returned -13.50% over the past 12 months, compared with -80.07% for AKTX (price return, excluding dividends). Past performance does not predict future results.

Are Akari Therapeutics and Aytu BioPharma in the same industry?

Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.

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