Align Technology (ALGN) vs Intuitive Surgical (ISRG)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 9, 2026.
Summary
Align Technology (ALGN) has outperformed Intuitive Surgical (ISRG) over the past year, gaining 6.0% versus a loss of 7.3%. Over five years, ISRG leads with a +25.3% price change compared with -76.1% for ALGN. Intuitive Surgical is the larger company by market cap ($146.76 billion vs $10.02 billion), about 14.6 times the size.
On valuation, Align Technology trades at a lower forward P/E (11.3x vs 34.3x for Intuitive Surgical). Intuitive Surgical converts more of its revenue into profit, with a net margin of 28.4% versus 10.2%.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | ALGN | ISRG |
|---|---|---|
| Share price | $141.03 | $415.41 |
| Market cap | $10.02B | $146.76B |
| 1-day change | +0.83% | +0.21% |
| YTD return | -9.68% | -26.65% |
| 1-year return | +5.97% | -7.29% |
| 5-year return | -76.08% | +25.31% |
| P/E ratio (TTM) | 24.53 | 47.64 |
| Forward P/E | 11.33 | 34.30 |
| EPS (TTM) | $5.75 | $8.72 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| Revenue (latest FY) | $4.03B | $10.06B |
| Revenue growth (YoY) | +0.90% | +20.51% |
| Net income (latest FY) | $410.35M | $2.86B |
| Gross margin | 67.19% | 66.00% |
| Operating margin | 13.53% | 29.27% |
| Net margin | 10.17% | 28.38% |
| 52-week high | $200.44 | $603.88 |
| 52-week low | $124.91 | $328.57 |
| Distance from 52-week high | -29.64% | -31.21% |
| Analyst consensus | buy | buy |
| Avg. price target upside | +43.03% | +14.94% |
| Average volume | 900.35K | 2.92M |
| Shares outstanding | 71.04M | 353.28M |
| Employees | 20,435 | 17,021 |
| Sector | Health Care | Health Care |
| Industry | Industrial Specialties | Industrial Specialties |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- Intuitive Surgical is about 14.6 times larger than Align Technology by market value ($146.76B vs $10.02B).
- ALGN has outperformed ISRG by 13.3 percentage points over the past year.
- Intuitive Surgical trades at a higher earnings multiple (47.6x vs 24.5x trailing P/E).
- Intuitive Surgical is more profitable, keeping 28.4 cents of every revenue dollar as net income versus 10.2 cents for Align Technology.
- Intuitive Surgical grew revenue faster in its latest fiscal year (+20.51% vs +0.90%).
About Align Technology
ALGN stock →Align Technology, Inc. provides Invisalign clear aligners, Vivera retainers, and iTero intraoral scanners and services in the United States, Switzerland, and internationally.
Health Care · Industrial Specialties · 20,435 employees
About Intuitive Surgical
ISRG stock →Intuitive Surgical, Inc. develops, manufactures, and markets products that enable physicians and healthcare providers to enhance the quality of and access to minimally invasive care in the United States and internationally.
Health Care · Industrial Specialties · 17,021 employees
ALGN vs ISRG FAQ
Which is bigger, Align Technology or Intuitive Surgical?
Intuitive Surgical (ISRG) is larger, with a market capitalization of $146.76B compared with $10.02B for Align Technology (ALGN).
Which stock has performed better over the past year, ALGN or ISRG?
ALGN returned +5.97% over the past 12 months, compared with -7.29% for ISRG (price return, excluding dividends). Past performance does not predict future results.
Which has the lower P/E ratio, ALGN or ISRG?
ALGN has the lower trailing P/E at 24.5, versus 47.6 for ISRG. A lower P/E is not by itself a sign of a better investment; it can reflect slower expected growth or higher risk.
Are Align Technology and Intuitive Surgical in the same industry?
Yes. Both are classified in the Industrial Specialties industry within the Health Care sector.