BioMarin Pharmaceutical (BMRN) vs Protagonist Therapeutics (PTGX)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 8, 2026.
Summary
Protagonist Therapeutics (PTGX) has outperformed BioMarin Pharmaceutical (BMRN) over the past year, gaining 115.2% versus a gain of 0.4%. Over five years, PTGX leads with a +355.0% price change compared with -27.7% for BMRN. BioMarin Pharmaceutical is the larger company by market cap ($10.63 billion vs $9.05 billion), about 1.2 times the size.
On valuation, Protagonist Therapeutics trades at a lower trailing P/E (135.8x vs 148.4x for BioMarin Pharmaceutical). BioMarin Pharmaceutical converts more of its revenue into profit, with a net margin of 10.8% versus -282.8%.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | BMRN | PTGX |
|---|---|---|
| Share price | $54.89 | $139.91 |
| Market cap | $10.63B | $9.05B |
| 1-day change | -0.56% | -0.72% |
| YTD return | -7.64% | +61.35% |
| 1-year return | +0.37% | +115.24% |
| 5-year return | -27.67% | +355.02% |
| P/E ratio (TTM) | 148.35 | 135.83 |
| Forward P/E | 8.28 | — |
| EPS (TTM) | $0.37 | $1.03 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| Revenue (latest FY) | $3.22B | $46.02M |
| Revenue growth (YoY) | +12.87% | -89.41% |
| Net income (latest FY) | $348.90M | $-130.15M |
| Gross margin | 77.73% | — |
| Operating margin | 12.71% | -343.63% |
| Net margin | 10.83% | -282.83% |
| 52-week high | $70.98 | $160.81 |
| 52-week low | $49.26 | $65.56 |
| Distance from 52-week high | -22.67% | -13.00% |
| Analyst consensus | buy | strong_buy |
| Avg. price target upside | +66.92% | +24.86% |
| Average volume | 2.01M | 632.64K |
| Shares outstanding | 193.57M | 64.71M |
| Employees | 3,221 | 141 |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- PTGX has outperformed BMRN by 114.9 percentage points over the past year.
- BioMarin Pharmaceutical is more profitable, keeping 10.8 cents of every revenue dollar as net income versus -282.8 cents for Protagonist Therapeutics.
- BioMarin Pharmaceutical grew revenue faster in its latest fiscal year (+12.87% vs -89.41%).
About BioMarin Pharmaceutical
BMRN stock →BioMarin Pharmaceutical Inc., a biotechnology company, engages in the development and commercialization of therapies for life-threatening rare diseases and medical conditions in the United States, Europe, Latin America, the Middle East, the Asia Pacific, and internationally. The company's products include VIMIZIM, an enzyme replacement therapy for the treatment of mucopolysaccharidosis (MPS) IV type A, a lysosomal storage disorder; VOXZOGO, a once daily injection analog of c-type natriuretic peptide (CNP) for the treatment of achondroplasia; NAGLAZYME, a recombinant form of N- acetylgalactosamine 4-sulfatase for patients with MPS VI; and PALYNZIQ, a PEGylated recombinant phenylalanine (Phe) ammonia lyase enzyme delivered through subcutaneous injection to reduce blood Phe concentrations.
Health Care · Biotechnology: Pharmaceutical Preparations · 3,221 employees
About Protagonist Therapeutics
PTGX stock →Protagonist Therapeutics, Inc. operates as a discovery and development company in the United States.
Health Care · Biotechnology: Pharmaceutical Preparations · 141 employees
BMRN vs PTGX FAQ
Which is bigger, BioMarin Pharmaceutical or Protagonist Therapeutics?
BioMarin Pharmaceutical (BMRN) is larger, with a market capitalization of $10.63B compared with $9.05B for Protagonist Therapeutics (PTGX).
Which stock has performed better over the past year, BMRN or PTGX?
PTGX returned +115.24% over the past 12 months, compared with +0.37% for BMRN (price return, excluding dividends). Past performance does not predict future results.
Which has the lower P/E ratio, BMRN or PTGX?
PTGX has the lower trailing P/E at 135.8, versus 148.4 for BMRN. A lower P/E is not by itself a sign of a better investment; it can reflect slower expected growth or higher risk.
Are BioMarin Pharmaceutical and Protagonist Therapeutics in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.