Cibus (CBUS) vs Spruce Biosciences (SPRB)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 8, 2026.
Summary
Cibus (CBUS) has outperformed Spruce Biosciences (SPRB) over the past year, gaining 13.3% versus a loss of 75.7%. Over five years, CBUS leads with a -98.9% price change compared with -99.8% for SPRB. Spruce Biosciences is the larger company by market cap ($127.6 million vs $123.8 million), about 1.0 times the size.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | CBUS | SPRB |
|---|---|---|
| Share price | $1.62 | $44.40 |
| Market cap | $123.81M | $127.61M |
| 1-day change | +3.18% | +3.77% |
| YTD return | -6.90% | -49.03% |
| 1-year return | +13.29% | -75.68% |
| 5-year return | -98.90% | -99.82% |
| Forward P/E | — | 8.92 |
| EPS (TTM) | $-1.62 | $-40.54 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| 52-week high | $4.19 | $199.20 |
| 52-week low | $1.09 | $40.33 |
| Distance from 52-week high | -61.35% | -77.71% |
| Analyst consensus | none | strong_buy |
| Avg. price target upside | +784.57% | +233.33% |
| Average volume | 208.04K | 77.72K |
| Shares outstanding | 76.43M | 2.87M |
| Employees | 118 | 22 |
| Sector | Industrials | Health Care |
| Industry | Agricultural Chemicals | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- CBUS has outperformed SPRB by 89.0 percentage points over the past year.
- The two companies sit in different sectors: Cibus in Industrials and Spruce Biosciences in Health Care.
About Cibus
CBUS stock →Cibus, Inc. is an agricultural biotechnology company that develops and licenses gene-edited plant traits.
Industrials · Agricultural Chemicals · 118 employees
About Spruce Biosciences
SPRB stock →Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders.
Health Care · Biotechnology: Pharmaceutical Preparations · 22 employees
CBUS vs SPRB FAQ
Which is bigger, Cibus or Spruce Biosciences?
Spruce Biosciences (SPRB) is larger, with a market capitalization of $127.61M compared with $123.81M for Cibus (CBUS).
Which stock has performed better over the past year, CBUS or SPRB?
CBUS returned +13.29% over the past 12 months, compared with -75.68% for SPRB (price return, excluding dividends). Past performance does not predict future results.
Are Cibus and Spruce Biosciences in the same industry?
No. Cibus is in the Industrials sector, while Spruce Biosciences is in Health Care.