Clene (CLNN) vs Hyperion DeFi (HYPD)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 8, 2026.
Summary
Clene (CLNN) has outperformed Hyperion DeFi (HYPD) over the past year, losing 56.8% versus a loss of 61.6%. Over five years, CLNN leads with a -96.8% price change compared with -99.2% for HYPD. Clene is the larger company by market cap ($55.2 million vs $51.2 million), about 1.1 times the size.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | CLNN | HYPD |
|---|---|---|
| Share price | $3.88 | $3.37 |
| Market cap | $55.15M | $51.16M |
| 1-day change | -1.02% | -6.27% |
| YTD return | -33.22% | +0.84% |
| 1-year return | -56.78% | -61.60% |
| 5-year return | -96.82% | -99.15% |
| EPS (TTM) | $-3.52 | $-6.46 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| 52-week high | $13.50 | $9.50 |
| 52-week low | $3.25 | $2.34 |
| Distance from 52-week high | -71.26% | -64.58% |
| Average volume | 99.70K | 445.34K |
| Shares outstanding | 14.21M | 15.20M |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
CLNN vs HYPD FAQ
Which is bigger, Clene or Hyperion DeFi?
Clene (CLNN) is larger, with a market capitalization of $55.15M compared with $51.16M for Hyperion DeFi (HYPD).
Which stock has performed better over the past year, CLNN or HYPD?
CLNN returned -56.78% over the past 12 months, compared with -61.60% for HYPD (price return, excluding dividends). Past performance does not predict future results.
Are Clene and Hyperion DeFi in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.