Inovio Pharmaceuticals (INO) vs Spruce Biosciences (SPRB)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 8, 2026.
Summary
Inovio Pharmaceuticals (INO) has outperformed Spruce Biosciences (SPRB) over the past year, losing 51.7% versus a loss of 75.7%. Over five years, INO leads with a -98.6% price change compared with -99.8% for SPRB. Spruce Biosciences is the larger company by market cap ($130.9 million vs $112.7 million), about 1.2 times the size.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | INO | SPRB |
|---|---|---|
| Share price | $1.09 | $45.54 |
| Market cap | $112.70M | $130.88M |
| 1-day change | -5.63% | +2.57% |
| YTD return | -33.62% | -49.03% |
| 1-year return | -51.67% | -75.68% |
| 5-year return | -98.63% | -99.82% |
| Forward P/E | — | 9.15 |
| EPS (TTM) | $-0.90 | $-39.12 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| 52-week high | $2.72 | $199.20 |
| 52-week low | $0.56 | $40.33 |
| Distance from 52-week high | -59.93% | -77.14% |
| Analyst consensus | — | strong_buy |
| Avg. price target upside | — | +224.99% |
| Average volume | 3.83M | 77.75K |
| Shares outstanding | 103.40M | 2.87M |
| Employees | — | 22 |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- INO has outperformed SPRB by 24.0 percentage points over the past year.
About Spruce Biosciences
SPRB stock →Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders.
Health Care · Biotechnology: Pharmaceutical Preparations · 22 employees
INO vs SPRB FAQ
Which is bigger, Inovio Pharmaceuticals or Spruce Biosciences?
Spruce Biosciences (SPRB) is larger, with a market capitalization of $130.88M compared with $112.70M for Inovio Pharmaceuticals (INO).
Which stock has performed better over the past year, INO or SPRB?
INO returned -51.67% over the past 12 months, compared with -75.68% for SPRB (price return, excluding dividends). Past performance does not predict future results.
Are Inovio Pharmaceuticals and Spruce Biosciences in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.