Karyopharm Therapeutics (KPTI) vs Tempest Therapeutics (TPST)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 8, 2026.
Summary
Karyopharm Therapeutics (KPTI) has outperformed Tempest Therapeutics (TPST) over the past year, losing 88.8% versus a loss of 92.6%. Over five years, KPTI leads with a -99.2% price change compared with -99.6% for TPST. Karyopharm Therapeutics is the larger company by market cap ($13.6 million vs $13.0 million), about 1.0 times the size.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | KPTI | TPST |
|---|---|---|
| Share price | $0.60 | $0.77 |
| Market cap | $13.61M | $13.01M |
| 1-day change | -6.98% | -2.70% |
| YTD return | -91.24% | -72.43% |
| 1-year return | -88.82% | -92.63% |
| 5-year return | -99.23% | -99.59% |
| EPS (TTM) | $-14.33 | $-3.93 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| 52-week high | $10.99 | $12.23 |
| 52-week low | $0.60 | $0.743 |
| Distance from 52-week high | -94.54% | -93.70% |
| Average volume | 1.70M | 2.59M |
| Shares outstanding | 22.68M | 16.89M |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
KPTI vs TPST FAQ
Which is bigger, Karyopharm Therapeutics or Tempest Therapeutics?
Karyopharm Therapeutics (KPTI) is larger, with a market capitalization of $13.61M compared with $13.01M for Tempest Therapeutics (TPST).
Which stock has performed better over the past year, KPTI or TPST?
KPTI returned -88.82% over the past 12 months, compared with -92.63% for TPST (price return, excluding dividends). Past performance does not predict future results.
Are Karyopharm Therapeutics and Tempest Therapeutics in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.