Nuvation Bio (NUVB) vs Septerna (SEPN)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 8, 2026.
Summary
Septerna (SEPN) has outperformed Nuvation Bio (NUVB) over the past year, gaining 71.3% versus a gain of 32.8%. Nuvation Bio is the larger company by market cap ($1.74 billion vs $1.72 billion), about 1.0 times the size.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | NUVB | SEPN |
|---|---|---|
| Share price | $4.95 | $36.90 |
| Market cap | $1.74B | $1.72B |
| 1-day change | +1.85% | +2.50% |
| YTD return | -45.76% | +29.12% |
| 1-year return | +32.79% | +71.35% |
| 5-year return | -49.11% | — |
| EPS (TTM) | $-0.44 | $-0.54 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| 52-week high | $9.75 | $51.10 |
| 52-week low | $3.36 | $17.55 |
| Distance from 52-week high | -49.23% | -27.79% |
| Analyst consensus | strong_buy | strong_buy |
| Avg. price target upside | +162.63% | +46.94% |
| Average volume | 5.65M | 393.97K |
| Shares outstanding | 350.12M | 46.68M |
| Employees | 305 | 123 |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- SEPN has outperformed NUVB by 38.6 percentage points over the past year.
About Nuvation Bio
NUVB stock →Nuvation Bio Inc., a clinical-stage biopharmaceutical company, focuses on developing product candidates for cancer treatment. The company's lead product candidate is IBTROZI (taletrectinib), a ROS1 inhibitor for the treatment of patients with ROS1+ non-small cell lung cancer.
Health Care · Biotechnology: Pharmaceutical Preparations · 305 employees
About Septerna
SEPN stock →Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves' disease and thyroid eye disease.
Health Care · Biotechnology: Pharmaceutical Preparations · 123 employees
NUVB vs SEPN FAQ
Which is bigger, Nuvation Bio or Septerna?
Nuvation Bio (NUVB) is larger, with a market capitalization of $1.74B compared with $1.72B for Septerna (SEPN).
Which stock has performed better over the past year, NUVB or SEPN?
SEPN returned +71.35% over the past 12 months, compared with +32.79% for NUVB (price return, excluding dividends). Past performance does not predict future results.
Are Nuvation Bio and Septerna in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.