Shuttle Pharmaceuticals (SHPH) vs Talphera (TLPH)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 9, 2026.
Summary
Talphera (TLPH) has outperformed Shuttle Pharmaceuticals (SHPH) over the past year, losing 18.2% versus a loss of 87.4%. Talphera is the larger company by market cap ($55.8 million vs $25.7 million), about 2.2 times the size.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | SHPH | TLPH |
|---|---|---|
| Share price | $5.40 | $1.08 |
| Market cap | $25.73M | $55.80M |
| 1-day change | -2.79% | -0.46% |
| YTD return | -69.17% | -5.26% |
| 1-year return | -87.36% | -18.18% |
| 5-year return | — | -94.71% |
| EPS (TTM) | $-16.87 | $-0.26 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| 52-week high | $55.90 | $1.57 |
| 52-week low | $2.58 | $0.69 |
| Distance from 52-week high | -90.34% | -31.53% |
| Analyst consensus | — | none |
| Avg. price target upside | — | +191.16% |
| Average volume | 1.36M | 238.38K |
| Shares outstanding | 4.76M | 51.91M |
| Employees | 2 | 12 |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- Talphera is about 2.2 times larger than Shuttle Pharmaceuticals by market value ($55.80M vs $25.73M).
- TLPH has outperformed SHPH by 69.2 percentage points over the past year.
About Shuttle Pharmaceuticals
SHPH stock →Shuttle Pharmaceuticals Holdings, Inc., a clinical stage pharmaceutical company, develops novel therapies to treat cancers. It owns a pharmaceutical software artificial intelligence (AI) driven platform for molecular discovery and early-stage drug development.
Health Care · Biotechnology: Pharmaceutical Preparations · 2 employees
About Talphera
TLPH stock →Talphera, Inc., a specialty pharmaceutical company, focuses on the development and commercialization of therapies for use in medically supervised settings. The company's lead product candidate, Niyad, is a lyophilized formulation of nafamostat that acts as a regional anticoagulant for infusion into the extracorporeal circuit.
Health Care · Biotechnology: Pharmaceutical Preparations · 12 employees
SHPH vs TLPH FAQ
Which is bigger, Shuttle Pharmaceuticals or Talphera?
Talphera (TLPH) is larger, with a market capitalization of $55.80M compared with $25.73M for Shuttle Pharmaceuticals (SHPH).
Which stock has performed better over the past year, SHPH or TLPH?
TLPH returned -18.18% over the past 12 months, compared with -87.36% for SHPH (price return, excluding dividends). Past performance does not predict future results.
Are Shuttle Pharmaceuticals and Talphera in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.