Spruce Biosciences (SPRB) vs Tiziana Life Sciences (TLSA)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 7, 2026.
Summary
Tiziana Life Sciences (TLSA) has outperformed Spruce Biosciences (SPRB) over the past year, losing 49.3% versus a loss of 75.7%. Over five years, TLSA leads with a -27.2% price change compared with -99.8% for SPRB. Tiziana Life Sciences is the larger company by market cap ($140.0 million vs $127.6 million), about 1.1 times the size.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | SPRB | TLSA |
|---|---|---|
| Share price | $44.40 | $1.10 |
| Market cap | $127.61M | $139.99M |
| 1-day change | +3.77% | -0.90% |
| YTD return | -49.03% | -26.17% |
| 1-year return | -75.68% | -49.31% |
| 5-year return | -99.82% | -27.15% |
| Forward P/E | 8.92 | — |
| EPS (TTM) | $-39.12 | $-0.16 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| 52-week high | $199.20 | $2.33 |
| 52-week low | $40.33 | $0.76 |
| Distance from 52-week high | -77.71% | -52.79% |
| Average volume | 77.72K | 712.06K |
| Shares outstanding | 2.87M | 127.26M |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- TLSA has outperformed SPRB by 26.4 percentage points over the past year.
SPRB vs TLSA FAQ
Which is bigger, Spruce Biosciences or Tiziana Life Sciences?
Tiziana Life Sciences (TLSA) is larger, with a market capitalization of $139.99M compared with $127.61M for Spruce Biosciences (SPRB).
Which stock has performed better over the past year, SPRB or TLSA?
TLSA returned -49.31% over the past 12 months, compared with -75.68% for SPRB (price return, excluding dividends). Past performance does not predict future results.
Are Spruce Biosciences and Tiziana Life Sciences in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.