Denali Therapeutics Stock Price History
NASDAQ: DNLIHealth CareBiotechnology: Biological Products (No Diagnostic Substances)USD
19.45+0.78 (+4.18%)
At close: Oct 9, 4:00 PM ET · Delayed 15 min
DNLI price history at a glance
The price history for Denali Therapeutics (DNLI) on this page begins on December 4, 2017, when the stock closed at $21.45; it most recently closed at $19.45 on October 5, 2026. The highest price in this record is $93.94, reached on December 21, 2020; the latest close is 79.3% below that peak. Across the 8 complete calendar years in the table, DNLI finished higher in 2 and lower in 6. Its best year was 2020 (+418.6%) and its worst was 2021 (-46.8%).
Over roughly 9 years the share price changed -9.3%, a -1.1% compound annual price return (excluding dividends). In the last 12 months alone, DNLI has gained 20.3%. Prices are split-adjusted closing prices; daily open, high, low, close and volume for the past year are listed below.
Summary generated from market data by MetaCap's automated system. Methodology
Key price levels
- High since 2017
- $93.94
- Date of high
- Dec 21, 2020
- Low since 2017
- $10.57
- Date of low
- Apr 7, 2025
- 52-week high
- $27.30
- 52-week low
- $13.75
- IPO year
- 2017
- Last close
- $19.45
DNLI returns
1 week
-2.75%
1 month
-9.83%
3 months
-24.26%
6 months
+1.14%
Year to date
+17.81%
1 year
+20.28%
3 years
-6.31%
5 years
-57.31%
DNLI price return, excluding dividends.
DNLI annual returns
| Year | Year-end close | Return |
|---|---|---|
| 2026 | 19.45 | +19.55% |
| 2025 | 16.27 | -23.47% |
| 2024 | 21.26 | -0.93% |
| 2023 | 21.46 | -22.83% |
| 2022 | 27.81 | -37.65% |
| 2021 | 44.60 | -46.75% |
| 2020 | 83.76 | +418.64% |
| 2019 | 16.15 | -20.48% |
| 2018 | 20.31 | +29.86% |
| 2017* | 15.64 | -27.09% |
* Partial year: the record begins after the start of 2017; return measured from the first available close.
2026 return is year to date.
DNLI daily prices (past year)
| Date | Open | High | Low | Close | Change |
|---|---|---|---|---|---|
| 18.47 | 19.52 | 18.46 | 19.45 | +4.18% | |
| 19.04 | 19.04 | 18.30 | 18.67 | -2.56% | |
| 18.95 | 19.43 | 18.89 | 19.16 | -0.62% | |
| 19.93 | 19.97 | 19.03 | 19.28 | -3.16% | |
| 20.09 | 20.09 | 19.54 | 19.91 | -0.45% | |
| 20.85 | 20.85 | 19.93 | 20.00 | -2.58% | |
| 20.55 | 20.85 | 20.40 | 20.53 | -0.68% | |
| 20.95 | 21.09 | 20.51 | 20.67 | -0.67% | |
| 20.88 | 21.01 | 20.41 | 20.81 | -0.81% | |
| 20.05 | 21.26 | 19.93 | 20.98 | +2.89% | |
| 20.46 | 20.60 | 19.96 | 20.39 | -0.39% | |
| 20.40 | 20.64 | 19.73 | 20.47 | +0.05% | |
| 21.50 | 21.51 | 20.33 | 20.46 | -5.28% | |
| 20.76 | 21.79 | 20.47 | 21.60 | +5.52% | |
| 19.99 | 20.55 | 19.40 | 20.47 | +3.80% | |
| 20.07 | 20.16 | 19.56 | 19.72 | -2.04% | |
| 20.57 | 20.65 | 19.90 | 20.13 | +0.35% | |
| 20.40 | 20.51 | 19.87 | 20.06 | -1.57% | |
| 21.01 | 21.10 | 20.27 | 20.38 | -3.96% | |
| 21.09 | 21.58 | 20.96 | 21.22 | +0.62% | |
| 21.65 | 21.79 | 21.06 | 21.09 | -1.45% | |
| 21.24 | 21.58 | 21.09 | 21.40 | -0.79% | |
| 21.69 | 22.06 | 21.34 | 21.57 | -2.31% | |
| 21.79 | 22.25 | 21.66 | 22.08 | -0.90% | |
| 22.32 | 22.48 | 22.15 | 22.28 | -2.28% | |
| 23.00 | 23.03 | 22.35 | 22.80 | -0.22% | |
| 23.33 | 23.86 | 22.53 | 22.85 | -1.78% | |
| 23.44 | 23.75 | 23.06 | 23.27 | -2.08% | |
| 23.72 | 24.01 | 23.41 | 23.76 | -1.00% | |
| 24.42 | 24.62 | 23.92 | 24.00 | -2.72% | |
| 24.43 | 24.74 | 24.16 | 24.67 | +0.41% | |
| 24.75 | 24.89 | 24.33 | 24.57 | -1.44% | |
| 24.86 | 25.26 | 24.81 | 24.93 | +3.02% | |
| 24.88 | 25.27 | 23.41 | 24.20 | -2.89% | |
| 25.25 | 25.37 | 24.60 | 24.92 | -0.12% | |
| 25.15 | 25.60 | 24.65 | 24.95 | -2.88% | |
| 25.00 | 25.70 | 24.61 | 25.69 | +5.68% | |
| 24.17 | 24.49 | 24.01 | 24.31 | -0.16% | |
| 24.29 | 24.66 | 24.11 | 24.35 | -0.20% | |
| 24.53 | 24.62 | 24.12 | 24.40 | -1.69% | |
| 25.24 | 25.64 | 24.81 | 24.82 | -1.78% | |
| 24.51 | 25.34 | 24.20 | 25.27 | +2.35% | |
| 25.07 | 25.29 | 24.59 | 24.69 | -1.24% | |
| 24.71 | 25.04 | 24.21 | 25.00 | +0.68% | |
| 25.41 | 25.74 | 24.24 | 24.83 | +0.40% | |
| 24.48 | 24.99 | 24.37 | 24.73 | +1.27% | |
| 24.29 | 24.55 | 23.96 | 24.42 | +1.03% | |
| 23.55 | 24.30 | 23.23 | 24.17 | +4.41% | |
| 22.85 | 23.50 | 22.63 | 23.15 | +0.56% | |
| 24.34 | 24.35 | 22.99 | 23.02 | -5.46% | |
| 23.83 | 24.68 | 23.79 | 24.35 | +2.10% | |
| 24.20 | 24.39 | 23.61 | 23.85 | -0.83% | |
| 23.92 | 24.06 | 23.15 | 24.05 | +2.04% | |
| 23.59 | 24.17 | 23.44 | 23.57 | +1.99% | |
| 23.52 | 23.65 | 22.64 | 23.11 | -1.32% | |
| 23.23 | 23.57 | 22.82 | 23.42 | -0.93% | |
| 23.61 | 24.05 | 23.42 | 23.64 | -0.80% | |
| 22.68 | 23.90 | 22.52 | 23.83 | +4.06% | |
| 23.29 | 23.87 | 22.85 | 22.90 | -1.67% | |
| 22.69 | 23.80 | 22.58 | 23.29 | +2.46% | |
| 22.81 | 23.00 | 22.02 | 22.73 | -1.26% | |
| 22.50 | 23.05 | 22.01 | 23.02 | +1.63% | |
| 26.17 | 26.32 | 22.03 | 22.65 | -14.46% | |
| 25.70 | 26.60 | 24.77 | 26.48 | +3.12% | |
| 27.06 | 27.11 | 25.25 | 25.68 | -5.62% | |
| 26.69 | 27.30 | 26.55 | 27.21 | +1.95% | |
| 26.08 | 26.74 | 25.56 | 26.69 | +1.44% | |
| 25.93 | 26.76 | 25.36 | 26.31 | +2.21% | |
| 25.79 | 26.07 | 25.05 | 25.74 | -0.35% | |
| 26.23 | 26.80 | 25.43 | 25.83 | -0.58% | |
| 25.72 | 26.30 | 25.62 | 25.98 | +1.01% | |
| 25.96 | 26.36 | 25.62 | 25.72 | -0.66% | |
| 25.38 | 26.19 | 25.36 | 25.89 | +1.25% | |
| 24.78 | 25.70 | 24.65 | 25.57 | +3.40% | |
| 24.83 | 25.97 | 24.59 | 24.73 | -0.36% | |
| 25.14 | 25.69 | 24.72 | 24.82 | +0.20% | |
| 23.76 | 25.31 | 23.51 | 24.77 | +2.99% | |
| 23.90 | 24.34 | 23.65 | 24.05 | +3.17% | |
| 24.17 | 24.65 | 23.21 | 23.31 | -0.77% | |
| 22.12 | 24.21 | 22.09 | 23.49 | +7.11% | |
| 22.12 | 22.47 | 21.68 | 21.93 | -1.31% | |
| 21.86 | 22.44 | 21.41 | 22.22 | +2.59% | |
| 21.02 | 22.15 | 20.92 | 21.66 | +3.04% | |
| 20.78 | 21.69 | 20.37 | 21.02 | +1.99% | |
| 20.61 | 21.71 | 20.16 | 20.61 | -0.87% | |
| 19.84 | 20.94 | 19.45 | 20.79 | +6.40% | |
| 19.85 | 20.05 | 19.19 | 19.54 | +0.10% | |
| 19.94 | 19.94 | 19.24 | 19.52 | -3.08% | |
| 19.70 | 21.10 | 19.67 | 20.14 | +2.44% | |
| 19.34 | 19.69 | 19.19 | 19.66 | +1.60% | |
| 19.96 | 20.13 | 18.92 | 19.35 | -5.19% | |
| 20.73 | 20.87 | 20.03 | 20.41 | -2.99% | |
| 20.85 | 21.18 | 20.84 | 21.04 | +0.43% | |
| 20.10 | 21.05 | 19.66 | 20.95 | +3.66% | |
| 19.62 | 20.34 | 19.58 | 20.21 | +4.28% | |
| 18.86 | 19.63 | 18.60 | 19.38 | +3.97% | |
| 18.52 | 19.06 | 18.18 | 18.64 | -3.42% | |
| 18.55 | 19.33 | 18.35 | 19.30 | +2.50% | |
| 18.21 | 19.18 | 18.11 | 18.83 | +3.98% | |
| 18.39 | 18.40 | 17.71 | 18.11 | -1.58% | |
| 18.62 | 19.11 | 18.23 | 18.40 | -1.18% | |
| 19.01 | 19.37 | 18.50 | 18.62 | -3.97% | |
| 19.97 | 20.00 | 18.88 | 19.39 | -2.07% | |
| 19.27 | 19.95 | 19.27 | 19.80 | +1.75% | |
| 19.76 | 19.97 | 19.18 | 19.46 | -1.07% | |
| 19.69 | 20.55 | 19.43 | 19.67 | +0.25% | |
| 19.44 | 20.53 | 19.44 | 19.62 | -0.46% | |
| 20.40 | 20.41 | 19.19 | 19.71 | -3.43% | |
| 19.22 | 20.49 | 18.91 | 20.41 | +7.88% | |
| 18.99 | 19.40 | 18.33 | 18.92 | +1.34% | |
| 18.14 | 19.15 | 18.10 | 18.67 | +2.02% | |
| 18.70 | 18.81 | 18.21 | 18.30 | -2.24% | |
| 18.69 | 18.92 | 18.33 | 18.72 | +0.65% | |
| 19.60 | 20.17 | 18.23 | 18.60 | -7.28% | |
| 19.97 | 20.44 | 19.84 | 20.06 | +0.60% | |
| 19.76 | 20.36 | 19.76 | 19.94 | +0.35% | |
| 19.45 | 20.05 | 19.27 | 19.87 | +2.16% | |
| 20.28 | 20.36 | 19.21 | 19.45 | -3.95% | |
| 20.28 | 20.57 | 20.00 | 20.25 | +0.60% | |
| 20.50 | 20.75 | 19.94 | 20.13 | -2.00% | |
| 20.76 | 20.88 | 20.09 | 20.54 | -0.15% | |
| 21.13 | 21.37 | 20.54 | 20.57 | -0.68% | |
| 21.63 | 21.80 | 20.64 | 20.71 | -4.47% | |
| 20.24 | 21.71 | 20.20 | 21.68 | +7.54% | |
| 19.43 | 20.29 | 19.43 | 20.16 | +3.81% | |
| 19.23 | 19.93 | 19.02 | 19.42 | +0.99% | |
| 19.41 | 19.63 | 18.96 | 19.23 | -0.31% | |
| 19.37 | 19.73 | 19.05 | 19.29 | -1.68% | |
| 20.04 | 20.29 | 19.26 | 19.62 | +1.08% | |
| 19.23 | 19.53 | 18.80 | 19.41 | +0.15% | |
| 20.60 | 20.80 | 19.22 | 19.38 | -6.15% | |
| 18.92 | 20.66 | 18.92 | 20.65 | +4.93% | |
| 19.56 | 20.00 | 19.33 | 19.68 | +2.50% | |
| 18.90 | 19.44 | 18.74 | 19.20 | +6.19% | |
| 18.26 | 18.46 | 17.86 | 18.08 | -0.44% | |
| 19.59 | 19.74 | 18.10 | 18.16 | -7.98% | |
| 22.53 | 22.58 | 19.74 | 19.74 | -12.17% | |
| 22.62 | 23.46 | 21.27 | 22.47 | +7.15% | |
| 20.73 | 21.21 | 20.54 | 20.97 | -0.57% | |
| 20.75 | 21.67 | 20.50 | 21.09 | +4.56% | |
| 19.74 | 20.51 | 19.63 | 20.17 | +2.13% | |
| 19.88 | 20.19 | 18.93 | 19.75 | -1.55% | |
| 20.51 | 20.66 | 19.90 | 20.06 | -3.14% | |
| 20.53 | 20.90 | 20.45 | 20.71 | +0.68% | |
| 20.54 | 21.16 | 20.31 | 20.57 | 0.00% | |
| 20.91 | 21.42 | 20.08 | 20.57 | -0.63% | |
| 21.03 | 21.53 | 20.00 | 20.70 | -4.21% | |
| 21.47 | 21.72 | 20.82 | 21.61 | +0.84% | |
| 21.31 | 21.82 | 21.09 | 21.43 | +0.56% | |
| 20.32 | 21.76 | 20.17 | 21.31 | +8.23% | |
| 19.46 | 19.76 | 19.05 | 19.69 | -0.05% | |
| 19.93 | 20.63 | 19.45 | 19.70 | -3.29% | |
| 20.29 | 20.92 | 19.94 | 20.37 | +1.75% | |
| 20.18 | 20.64 | 19.76 | 20.02 | -4.67% | |
| 21.14 | 21.52 | 20.58 | 21.00 | -0.85% | |
| 21.14 | 21.45 | 20.25 | 21.18 | -1.12% | |
| 22.20 | 22.40 | 21.00 | 21.42 | -3.90% | |
| 21.60 | 22.59 | 21.60 | 22.29 | +4.01% | |
| 20.86 | 21.56 | 20.49 | 21.43 | +2.73% | |
| 20.30 | 21.38 | 20.10 | 20.86 | +3.32% | |
| 20.00 | 20.51 | 19.69 | 20.19 | -0.25% | |
| 19.08 | 20.37 | 18.96 | 20.24 | +5.25% | |
| 19.01 | 20.01 | 19.00 | 19.23 | -0.26% | |
| 18.73 | 19.63 | 18.65 | 19.28 | +2.72% | |
| 19.24 | 20.12 | 18.61 | 18.77 | -2.14% | |
| 19.81 | 20.21 | 18.75 | 19.18 | -2.59% | |
| 19.91 | 20.00 | 18.66 | 19.69 | -0.66% | |
| 21.05 | 21.15 | 19.74 | 19.82 | -4.89% | |
| 21.20 | 21.20 | 20.16 | 20.84 | -1.14% | |
| 20.40 | 21.31 | 20.36 | 21.08 | +5.29% | |
| 21.16 | 21.48 | 19.76 | 20.02 | -5.92% | |
| 21.98 | 21.98 | 20.64 | 21.28 | -2.30% | |
| 22.89 | 23.77 | 21.32 | 21.78 | -4.22% | |
| 21.33 | 22.78 | 21.13 | 22.74 | +4.60% | |
| 21.37 | 22.00 | 21.13 | 21.74 | +0.69% | |
| 21.36 | 21.99 | 20.67 | 21.59 | +3.60% | |
| 21.43 | 21.81 | 20.35 | 20.84 | -1.93% | |
| 20.64 | 21.34 | 20.36 | 21.25 | +3.11% | |
| 20.01 | 21.15 | 19.56 | 20.61 | +1.78% | |
| 20.82 | 21.39 | 20.17 | 20.25 | -3.25% | |
| 18.74 | 21.09 | 18.67 | 20.93 | +12.53% | |
| 17.52 | 18.79 | 17.52 | 18.60 | +6.10% | |
| 17.42 | 17.81 | 17.18 | 17.53 | -2.56% | |
| 19.12 | 19.14 | 17.90 | 17.99 | -4.21% | |
| 18.25 | 18.99 | 17.88 | 18.78 | +2.79% | |
| 18.09 | 18.48 | 17.94 | 18.27 | +0.88% | |
| 17.98 | 18.18 | 17.65 | 18.11 | +0.89% | |
| 17.25 | 17.98 | 16.96 | 17.95 | +5.09% | |
| 17.39 | 17.71 | 17.03 | 17.08 | +0.06% | |
| 16.98 | 17.57 | 16.64 | 17.07 | +0.71% | |
| 17.48 | 17.95 | 16.70 | 16.95 | -1.51% | |
| 16.13 | 17.25 | 16.00 | 17.21 | +7.43% | |
| 16.20 | 16.53 | 15.34 | 16.02 | -1.54% | |
| 16.66 | 16.69 | 15.69 | 16.27 | -1.45% | |
| 16.42 | 16.67 | 16.28 | 16.51 | +0.61% | |
| 16.51 | 16.67 | 16.34 | 16.41 | -1.03% | |
| 16.70 | 16.91 | 16.44 | 16.58 | -1.72% | |
| 16.92 | 16.93 | 16.55 | 16.87 | -0.71% | |
| 16.90 | 17.05 | 16.72 | 16.99 | +1.07% | |
| 17.43 | 17.62 | 16.72 | 16.81 | -3.78% | |
| 16.90 | 17.85 | 16.81 | 17.47 | +3.68% | |
| 16.84 | 17.31 | 16.81 | 16.85 | +0.48% | |
| 16.94 | 17.28 | 16.74 | 16.77 | -0.24% | |
| 16.96 | 17.30 | 16.66 | 16.81 | -1.23% | |
| 17.40 | 17.55 | 16.83 | 17.02 | -1.85% | |
| 18.14 | 18.17 | 17.22 | 17.34 | -3.56% | |
| 17.41 | 18.30 | 17.24 | 17.98 | +3.51% | |
| 17.37 | 17.76 | 17.20 | 17.37 | -1.14% | |
| 18.30 | 19.59 | 17.52 | 17.57 | -10.63% | |
| 19.62 | 19.87 | 19.19 | 19.66 | -0.15% | |
| 20.23 | 20.57 | 19.50 | 19.69 | -1.35% | |
| 20.37 | 20.61 | 19.94 | 19.96 | -0.75% | |
| 18.77 | 20.49 | 18.47 | 20.11 | +5.84% | |
| 18.03 | 19.16 | 17.90 | 19.00 | +6.50% | |
| 18.22 | 18.48 | 17.65 | 17.84 | -1.76% | |
| 19.10 | 19.13 | 18.00 | 18.16 | -6.73% | |
| 19.46 | 19.53 | 18.95 | 19.47 | +0.36% | |
| 19.10 | 19.58 | 18.74 | 19.40 | +1.41% | |
| 18.97 | 19.63 | 18.88 | 19.13 | +1.06% | |
| 18.12 | 19.00 | 18.03 | 18.93 | +5.17% | |
| 16.93 | 18.23 | 16.87 | 18.00 | +4.90% | |
| 16.96 | 17.95 | 16.87 | 17.16 | +1.42% | |
| 17.36 | 17.60 | 16.85 | 16.92 | -3.20% | |
| 17.25 | 17.65 | 16.93 | 17.48 | +0.63% | |
| 17.40 | 17.83 | 17.25 | 17.37 | -0.40% | |
| 16.79 | 18.21 | 16.78 | 17.44 | +1.69% | |
| 17.23 | 17.84 | 16.66 | 17.15 | -2.11% | |
| 17.59 | 18.70 | 17.17 | 17.52 | -0.34% | |
| 15.58 | 17.68 | 15.18 | 17.58 | +12.69% | |
| 15.42 | 16.56 | 15.33 | 15.60 | +3.86% | |
| 14.56 | 15.22 | 13.75 | 15.02 | +4.23% | |
| 14.82 | 15.10 | 14.30 | 14.41 | -3.22% | |
| 14.84 | 14.99 | 14.56 | 14.89 | -0.20% | |
| 15.10 | 15.29 | 14.83 | 14.92 | -2.86% | |
| 15.98 | 16.33 | 15.00 | 15.36 | -5.65% | |
| 16.25 | 16.45 | 15.90 | 16.28 | -0.61% | |
| 16.00 | 16.98 | 16.00 | 16.38 | +0.80% | |
| 16.79 | 16.98 | 16.04 | 16.25 | -3.96% | |
| 16.37 | 17.02 | 16.04 | 16.92 | +4.38% | |
| 16.17 | 16.78 | 16.12 | 16.21 | +1.57% | |
| 16.00 | 16.41 | 15.89 | 15.96 | +0.50% | |
| 15.86 | 16.09 | 15.53 | 15.88 | -0.44% | |
| 16.97 | 17.26 | 15.92 | 15.95 | -5.96% | |
| 17.33 | 17.40 | 16.85 | 16.96 | -1.68% | |
| 16.97 | 17.72 | 16.91 | 17.25 | +3.54% | |
| 16.44 | 16.80 | 16.23 | 16.66 | -0.36% | |
| 16.49 | 17.39 | 16.30 | 16.72 | +2.51% | |
| 15.23 | 16.43 | 15.19 | 16.31 | +7.23% | |
| 14.51 | 15.29 | 14.02 | 15.21 | +1.54% | |
| 15.42 | 15.62 | 14.98 | 14.98 | -2.54% | |
| 16.20 | 16.51 | 15.00 | 15.37 | -4.95% | |
| 15.66 | 16.51 | 15.66 | 16.17 | — |
Prices are adjusted for stock splits. See adjusted closing price for how dividends and splits affect history, and the DNLI chart for longer ranges.