Prime Medicine Stock Price History
NASDAQ: PRMEHealth CareBiotechnology: Biological Products (No Diagnostic Substances)USD
3.99+0.41 (+11.45%)
At close: Oct 9, 4:00 PM ET · Delayed 15 min
PRME price history at a glance
The price history for Prime Medicine (PRME) on this page begins on October 17, 2022, when the stock closed at $15.76; it most recently closed at $3.99 on October 5, 2026. The highest price in this record is $21.73, reached on November 14, 2022; the latest close is 81.6% below that peak. Across the 3 complete calendar years in the table, PRME finished higher in 1 and lower in 2. Its best year was 2025 (+5.4%) and its worst was 2024 (-62.2%).
Over roughly 4 years the share price changed -74.7%, a -29.3% compound annual price return (excluding dividends). In the last 12 months alone, PRME has lost 36.0%. Prices are split-adjusted closing prices; daily open, high, low, close and volume for the past year are listed below.
Summary generated from market data by MetaCap's automated system. Methodology
Key price levels
- High since 2022
- $21.73
- Date of high
- Nov 14, 2022
- Low since 2022
- $1.11
- Date of low
- May 19, 2025
- 52-week high
- $6.65
- 52-week low
- $2.67
- IPO year
- 2022
- Last close
- $3.99
PRME returns
1 week
+33.89%
1 month
+14.99%
3 months
+5.56%
6 months
+16.33%
Year to date
+14.99%
1 year
-35.96%
3 years
-43.88%
PRME price return, excluding dividends.
PRME annual returns
| Year | Year-end close | Return |
|---|---|---|
| 2026 | 3.99 | +13.03% |
| 2025 | 3.53 | +5.37% |
| 2024 | 3.35 | -62.19% |
| 2023 | 8.86 | -52.31% |
| 2022* | 18.58 | +17.89% |
* Partial year: the record begins after the start of 2022; return measured from the first available close.
2026 return is year to date.
PRME daily prices (past year)
| Date | Open | High | Low | Close | Change |
|---|---|---|---|---|---|
| 3.61 | 4.14 | 3.54 | 3.99 | +11.45% | |
| 3.83 | 3.90 | 3.52 | 3.58 | -8.21% | |
| 3.32 | 4.02 | 3.30 | 3.90 | +11.43% | |
| 3.56 | 3.72 | 3.26 | 3.50 | +9.03% | |
| 3.00 | 3.26 | 2.88 | 3.21 | +7.72% | |
| 3.05 | 3.08 | 2.92 | 2.98 | -0.33% | |
| 3.05 | 3.11 | 2.98 | 2.99 | -2.13% | |
| 3.11 | 3.19 | 3.02 | 3.06 | -1.13% | |
| 2.93 | 3.14 | 2.88 | 3.09 | +7.48% | |
| 2.85 | 2.92 | 2.77 | 2.88 | -0.86% | |
| 3.42 | 3.44 | 2.88 | 2.90 | -5.54% | |
| 3.11 | 3.13 | 2.99 | 3.07 | -1.92% | |
| 3.53 | 3.53 | 3.12 | 3.13 | -11.58% | |
| 3.22 | 3.57 | 3.20 | 3.54 | +10.97% | |
| 3.19 | 3.27 | 3.10 | 3.19 | +2.24% | |
| 3.13 | 3.17 | 3.05 | 3.12 | -0.64% | |
| 3.11 | 3.39 | 3.10 | 3.14 | +4.67% | |
| 3.18 | 3.22 | 2.93 | 3.00 | -4.46% | |
| 3.18 | 3.22 | 3.00 | 3.14 | -1.26% | |
| 3.10 | 3.28 | 3.10 | 3.18 | +1.60% | |
| 3.38 | 3.44 | 3.10 | 3.13 | -6.57% | |
| 3.37 | 3.42 | 3.31 | 3.35 | -3.46% | |
| 3.47 | 3.54 | 3.29 | 3.47 | -2.53% | |
| 3.65 | 3.65 | 3.41 | 3.56 | -3.78% | |
| 3.83 | 3.86 | 3.65 | 3.70 | -0.27% | |
| 3.70 | 3.72 | 3.49 | 3.71 | +1.09% | |
| 3.50 | 3.71 | 3.47 | 3.67 | +2.80% | |
| 3.54 | 3.71 | 3.48 | 3.57 | -0.56% | |
| 3.54 | 3.64 | 3.46 | 3.59 | -0.55% | |
| 3.57 | 3.70 | 3.48 | 3.61 | -0.82% | |
| 3.55 | 3.67 | 3.48 | 3.64 | +1.68% | |
| 3.66 | 3.66 | 3.44 | 3.58 | -3.50% | |
| 3.30 | 3.71 | 3.29 | 3.71 | +14.15% | |
| 3.38 | 3.40 | 3.20 | 3.25 | -4.13% | |
| 3.26 | 3.49 | 3.24 | 3.39 | +4.63% | |
| 3.43 | 3.50 | 3.20 | 3.24 | -8.47% | |
| 3.29 | 3.59 | 3.25 | 3.54 | +16.07% | |
| 3.10 | 3.20 | 3.02 | 3.05 | -3.79% | |
| 3.07 | 3.19 | 3.02 | 3.17 | +2.59% | |
| 3.14 | 3.14 | 3.00 | 3.09 | -2.52% | |
| 3.23 | 3.29 | 3.13 | 3.17 | -0.94% | |
| 3.24 | 3.31 | 3.17 | 3.20 | -1.84% | |
| 3.20 | 3.29 | 3.09 | 3.26 | +3.49% | |
| 3.09 | 3.32 | 3.06 | 3.15 | +2.27% | |
| 3.00 | 3.12 | 2.97 | 3.08 | +4.41% | |
| 3.06 | 3.15 | 2.91 | 2.95 | -4.22% | |
| 2.98 | 3.12 | 2.89 | 3.08 | +3.36% | |
| 2.88 | 2.98 | 2.82 | 2.98 | +6.05% | |
| 2.91 | 2.91 | 2.72 | 2.81 | -3.77% | |
| 3.03 | 3.04 | 2.91 | 2.92 | -3.31% | |
| 3.04 | 3.14 | 2.99 | 3.02 | -0.33% | |
| 3.07 | 3.12 | 2.96 | 3.03 | -1.94% | |
| 3.00 | 3.10 | 2.87 | 3.09 | +2.66% | |
| 2.97 | 3.18 | 2.97 | 3.01 | +2.03% | |
| 3.00 | 3.03 | 2.86 | 2.95 | -0.67% | |
| 3.05 | 3.06 | 2.95 | 2.97 | -3.88% | |
| 3.11 | 3.16 | 3.04 | 3.09 | -0.96% | |
| 3.07 | 3.15 | 2.93 | 3.12 | +2.30% | |
| 3.15 | 3.22 | 3.02 | 3.05 | -2.56% | |
| 3.15 | 3.22 | 3.08 | 3.13 | -2.80% | |
| 3.44 | 3.45 | 3.17 | 3.22 | -7.74% | |
| 3.47 | 3.52 | 3.39 | 3.49 | +0.58% | |
| 3.48 | 3.56 | 3.39 | 3.47 | -1.28% | |
| 3.69 | 3.69 | 3.50 | 3.52 | -7.01% | |
| 4.20 | 4.27 | 3.62 | 3.78 | -10.64% | |
| 4.58 | 4.73 | 4.17 | 4.23 | -8.44% | |
| 4.31 | 4.83 | 4.30 | 4.62 | +15.79% | |
| 4.04 | 4.10 | 3.78 | 3.99 | 0.00% | |
| 3.83 | 4.01 | 3.66 | 3.99 | +3.10% | |
| 3.90 | 4.32 | 3.80 | 3.87 | -0.51% | |
| 3.64 | 3.96 | 3.61 | 3.89 | +5.42% | |
| 3.77 | 3.79 | 3.62 | 3.69 | -0.81% | |
| 3.73 | 3.94 | 3.58 | 3.72 | +8.45% | |
| 3.14 | 3.45 | 3.14 | 3.43 | +7.86% | |
| 3.11 | 3.24 | 3.02 | 3.18 | +1.92% | |
| 3.25 | 3.41 | 3.08 | 3.12 | -3.70% | |
| 3.29 | 3.55 | 3.23 | 3.24 | -3.86% | |
| 3.33 | 3.57 | 3.30 | 3.37 | +4.33% | |
| 3.24 | 3.37 | 3.10 | 3.23 | +2.22% | |
| 2.91 | 3.27 | 2.87 | 3.16 | +10.10% | |
| 2.90 | 2.98 | 2.80 | 2.87 | -1.03% | |
| 2.92 | 3.06 | 2.84 | 2.90 | +4.50% | |
| 2.82 | 2.86 | 2.76 | 2.78 | -1.60% | |
| 2.71 | 2.87 | 2.67 | 2.82 | +4.06% | |
| 2.85 | 2.96 | 2.71 | 2.71 | -5.90% | |
| 2.99 | 3.05 | 2.79 | 2.88 | -2.70% | |
| 3.14 | 3.15 | 2.92 | 2.96 | -3.27% | |
| 3.44 | 3.44 | 2.94 | 3.06 | -11.82% | |
| 3.17 | 3.61 | 3.17 | 3.47 | +10.51% | |
| 3.27 | 3.27 | 3.08 | 3.14 | -2.18% | |
| 3.33 | 3.37 | 3.06 | 3.21 | -5.59% | |
| 3.54 | 3.54 | 3.28 | 3.40 | -4.23% | |
| 3.39 | 3.56 | 3.26 | 3.55 | +4.41% | |
| 3.25 | 3.43 | 3.12 | 3.40 | +3.03% | |
| 2.98 | 3.45 | 2.98 | 3.30 | +11.11% | |
| 3.01 | 3.05 | 2.89 | 2.97 | 0.00% | |
| 2.95 | 3.10 | 2.92 | 2.97 | +0.68% | |
| 2.81 | 2.97 | 2.75 | 2.95 | +4.24% | |
| 2.70 | 2.87 | 2.70 | 2.83 | +4.81% | |
| 2.78 | 2.81 | 2.68 | 2.70 | -3.91% | |
| 2.94 | 2.98 | 2.75 | 2.81 | -4.10% | |
| 3.08 | 3.09 | 2.93 | 2.93 | -6.39% | |
| 3.30 | 3.35 | 3.11 | 3.13 | -4.28% | |
| 3.25 | 3.35 | 3.23 | 3.27 | -0.91% | |
| 3.25 | 3.36 | 3.19 | 3.30 | +1.85% | |
| 3.20 | 3.60 | 3.19 | 3.24 | +0.93% | |
| 3.21 | 3.40 | 3.09 | 3.21 | +3.05% | |
| 3.41 | 3.55 | 3.06 | 3.12 | -8.65% | |
| 3.45 | 3.49 | 3.28 | 3.41 | +0.59% | |
| 3.49 | 3.56 | 3.28 | 3.39 | -2.31% | |
| 3.40 | 3.58 | 3.37 | 3.47 | +1.76% | |
| 3.52 | 3.53 | 3.35 | 3.41 | -3.81% | |
| 3.54 | 3.69 | 3.50 | 3.55 | +0.42% | |
| 3.63 | 3.69 | 3.51 | 3.53 | -4.34% | |
| 3.64 | 3.80 | 3.62 | 3.69 | +0.54% | |
| 3.70 | 3.98 | 3.64 | 3.67 | -0.81% | |
| 3.82 | 3.87 | 3.66 | 3.70 | -3.65% | |
| 3.97 | 4.03 | 3.78 | 3.84 | -3.03% | |
| 3.82 | 3.97 | 3.81 | 3.96 | +3.94% | |
| 3.89 | 3.96 | 3.75 | 3.81 | -2.06% | |
| 3.77 | 3.92 | 3.70 | 3.89 | +2.10% | |
| 3.78 | 3.91 | 3.76 | 3.81 | +3.81% | |
| 3.79 | 3.79 | 3.61 | 3.67 | -3.17% | |
| 3.76 | 3.84 | 3.66 | 3.79 | +2.43% | |
| 3.69 | 3.87 | 3.65 | 3.70 | +1.09% | |
| 3.38 | 3.73 | 3.36 | 3.66 | +6.71% | |
| 3.50 | 3.54 | 3.27 | 3.43 | -2.28% | |
| 3.51 | 3.55 | 3.45 | 3.51 | -0.85% | |
| 3.67 | 3.71 | 3.44 | 3.54 | +3.81% | |
| 3.31 | 3.42 | 3.19 | 3.41 | +2.10% | |
| 3.31 | 3.50 | 3.29 | 3.34 | +0.60% | |
| 3.23 | 3.45 | 3.23 | 3.32 | -2.06% | |
| 3.55 | 3.73 | 3.38 | 3.39 | -2.59% | |
| 3.23 | 3.51 | 3.23 | 3.48 | +10.48% | |
| 3.37 | 3.42 | 3.04 | 3.15 | -6.80% | |
| 3.57 | 3.64 | 3.29 | 3.38 | -7.14% | |
| 3.56 | 3.84 | 3.56 | 3.64 | +0.28% | |
| 3.59 | 3.75 | 3.59 | 3.63 | +3.12% | |
| 3.51 | 3.58 | 3.43 | 3.52 | -1.68% | |
| 3.59 | 3.72 | 3.52 | 3.58 | +1.70% | |
| 3.69 | 3.77 | 3.52 | 3.52 | -4.35% | |
| 3.46 | 3.76 | 3.45 | 3.68 | +4.25% | |
| 3.65 | 3.72 | 3.53 | 3.53 | -4.85% | |
| 3.63 | 3.76 | 3.63 | 3.71 | +1.09% | |
| 3.72 | 3.77 | 3.57 | 3.67 | +0.55% | |
| 3.80 | 3.83 | 3.63 | 3.65 | -2.14% | |
| 3.99 | 3.99 | 3.67 | 3.73 | -2.61% | |
| 4.05 | 4.13 | 3.70 | 3.83 | -5.43% | |
| 4.16 | 4.40 | 4.01 | 4.05 | -1.46% | |
| 3.88 | 4.38 | 3.86 | 4.11 | +2.49% | |
| 3.80 | 4.09 | 3.73 | 4.01 | +2.04% | |
| 3.98 | 4.13 | 3.86 | 3.93 | -4.61% | |
| 4.28 | 4.37 | 4.12 | 4.12 | -2.60% | |
| 4.46 | 4.51 | 4.20 | 4.23 | -9.23% | |
| 4.40 | 4.77 | 4.39 | 4.66 | +0.87% | |
| 4.25 | 4.64 | 4.22 | 4.62 | +5.48% | |
| 4.12 | 4.48 | 4.10 | 4.38 | +6.05% | |
| 3.88 | 4.15 | 3.85 | 4.13 | +7.83% | |
| 3.35 | 3.86 | 3.35 | 3.83 | +14.67% | |
| 3.27 | 3.40 | 3.17 | 3.34 | +2.14% | |
| 3.28 | 3.37 | 3.20 | 3.27 | -1.80% | |
| 3.25 | 3.35 | 3.18 | 3.33 | +1.22% | |
| 3.28 | 3.39 | 3.22 | 3.29 | -0.60% | |
| 3.27 | 3.38 | 3.16 | 3.31 | +0.30% | |
| 3.35 | 3.47 | 3.28 | 3.30 | -0.60% | |
| 3.45 | 3.50 | 3.20 | 3.32 | -3.77% | |
| 3.42 | 3.46 | 3.28 | 3.45 | +0.88% | |
| 3.57 | 3.65 | 3.40 | 3.42 | -4.74% | |
| 3.58 | 3.62 | 3.40 | 3.59 | +0.56% | |
| 3.36 | 3.59 | 3.30 | 3.57 | +10.19% | |
| 3.42 | 3.45 | 3.21 | 3.24 | -6.76% | |
| 3.81 | 3.84 | 3.43 | 3.48 | -8.79% | |
| 3.86 | 4.03 | 3.55 | 3.81 | +0.26% | |
| 3.75 | 4.04 | 3.75 | 3.80 | -0.26% | |
| 4.04 | 4.21 | 3.76 | 3.81 | -8.19% | |
| 4.00 | 4.18 | 3.99 | 4.15 | +2.98% | |
| 4.35 | 4.40 | 4.01 | 4.03 | -5.84% | |
| 4.31 | 4.56 | 4.22 | 4.28 | +2.39% | |
| 4.40 | 4.41 | 4.08 | 4.18 | -5.64% | |
| 4.66 | 4.66 | 4.34 | 4.43 | -5.24% | |
| 4.01 | 4.70 | 3.99 | 4.68 | +16.58% | |
| 4.00 | 4.07 | 3.82 | 4.01 | +3.08% | |
| 3.77 | 4.00 | 3.73 | 3.89 | -2.26% | |
| 3.98 | 4.16 | 3.79 | 3.98 | -0.25% | |
| 4.31 | 4.31 | 3.92 | 3.99 | -7.42% | |
| 4.16 | 4.60 | 4.08 | 4.31 | +3.61% | |
| 4.35 | 4.35 | 4.04 | 4.16 | -2.80% | |
| 4.06 | 4.34 | 4.00 | 4.28 | +8.63% | |
| 4.00 | 4.05 | 3.86 | 3.94 | +0.51% | |
| 4.00 | 4.00 | 3.85 | 3.92 | -2.97% | |
| 3.79 | 4.17 | 3.75 | 4.04 | +9.19% | |
| 3.60 | 3.87 | 3.56 | 3.70 | +3.64% | |
| 3.65 | 3.71 | 3.43 | 3.57 | +1.13% | |
| 3.50 | 3.54 | 3.33 | 3.53 | +1.73% | |
| 3.46 | 3.48 | 3.29 | 3.47 | +0.87% | |
| 3.37 | 3.51 | 3.34 | 3.44 | +2.08% | |
| 3.45 | 3.51 | 3.33 | 3.37 | -3.71% | |
| 3.57 | 3.59 | 3.47 | 3.50 | -1.96% | |
| 3.66 | 3.66 | 3.51 | 3.57 | -3.25% | |
| 3.72 | 3.79 | 3.62 | 3.69 | -0.27% | |
| 3.75 | 3.84 | 3.61 | 3.70 | +1.65% | |
| 3.64 | 3.85 | 3.61 | 3.64 | +1.11% | |
| 3.85 | 4.01 | 3.59 | 3.60 | -3.74% | |
| 3.94 | 4.12 | 3.72 | 3.74 | -3.61% | |
| 3.96 | 4.10 | 3.82 | 3.88 | -3.96% | |
| 4.22 | 4.24 | 3.95 | 4.04 | -1.46% | |
| 4.38 | 4.40 | 4.09 | 4.10 | -3.98% | |
| 4.33 | 4.42 | 4.14 | 4.27 | -1.39% | |
| 4.14 | 4.34 | 3.95 | 4.33 | +3.34% | |
| 4.25 | 4.34 | 4.06 | 4.19 | -0.48% | |
| 3.98 | 4.28 | 3.83 | 4.21 | +12.57% | |
| 3.88 | 3.94 | 3.68 | 3.74 | -2.86% | |
| 3.58 | 4.08 | 3.58 | 3.85 | +6.65% | |
| 3.30 | 3.64 | 3.27 | 3.61 | +9.39% | |
| 3.52 | 3.57 | 3.26 | 3.30 | -5.71% | |
| 3.70 | 3.74 | 3.48 | 3.50 | -8.38% | |
| 3.72 | 3.89 | 3.62 | 3.82 | +2.96% | |
| 3.75 | 3.78 | 3.62 | 3.71 | -0.27% | |
| 3.77 | 3.84 | 3.57 | 3.72 | -1.85% | |
| 3.68 | 3.82 | 3.67 | 3.79 | +4.41% | |
| 3.60 | 3.72 | 3.43 | 3.63 | -1.63% | |
| 3.83 | 4.04 | 3.59 | 3.69 | -0.81% | |
| 3.56 | 3.95 | 3.55 | 3.72 | +4.79% | |
| 3.79 | 3.83 | 3.47 | 3.55 | -7.07% | |
| 3.41 | 3.82 | 3.33 | 3.82 | +13.35% | |
| 3.18 | 3.53 | 3.17 | 3.37 | +1.20% | |
| 3.53 | 3.56 | 3.27 | 3.33 | -6.20% | |
| 3.92 | 4.00 | 3.53 | 3.55 | -9.44% | |
| 3.50 | 3.94 | 3.45 | 3.92 | +11.21% | |
| 4.09 | 4.11 | 3.52 | 3.53 | -7.48% | |
| 4.00 | 4.07 | 3.57 | 3.81 | -8.85% | |
| 4.43 | 4.44 | 4.17 | 4.18 | -5.00% | |
| 4.31 | 4.46 | 4.13 | 4.40 | +2.33% | |
| 4.29 | 4.56 | 4.27 | 4.30 | -5.70% | |
| 4.94 | 4.98 | 4.45 | 4.56 | -7.69% | |
| 4.37 | 5.03 | 4.31 | 4.94 | +13.56% | |
| 4.45 | 4.58 | 4.34 | 4.35 | -4.19% | |
| 4.86 | 4.86 | 4.47 | 4.54 | -5.81% | |
| 5.10 | 5.11 | 4.74 | 4.82 | -6.41% | |
| 5.00 | 5.20 | 4.77 | 5.15 | -3.38% | |
| 5.50 | 5.55 | 5.30 | 5.33 | -0.93% | |
| 5.18 | 5.43 | 5.00 | 5.38 | +5.28% | |
| 5.50 | 5.63 | 4.93 | 5.11 | -8.59% | |
| 6.19 | 6.30 | 5.58 | 5.59 | -9.55% | |
| 5.63 | 6.23 | 5.57 | 6.18 | +13.39% | |
| 5.65 | 5.76 | 5.39 | 5.45 | -6.03% | |
| 6.42 | 6.56 | 5.75 | 5.80 | -8.95% | |
| 6.19 | 6.65 | 5.91 | 6.37 | +6.34% | |
| 5.48 | 6.11 | 5.25 | 5.99 | +6.02% | |
| 5.83 | 5.90 | 5.43 | 5.65 | -0.53% | |
| 6.28 | 6.42 | 5.50 | 5.68 | -8.83% | |
| 6.38 | 6.44 | 6.08 | 6.23 | — |
Prices are adjusted for stock splits. See adjusted closing price for how dividends and splits affect history, and the PRME chart for longer ranges.