Protagonist Therapeutics Stock Price History
NASDAQ: PTGXHealth CareBiotechnology: Pharmaceutical PreparationsUSD
143.73+3.82 (+2.73%)
At close: Oct 9, 4:00 PM ET · Delayed 15 min
PTGX price history at a glance
The price history for Protagonist Therapeutics (PTGX) on this page begins on August 8, 2016, when the stock closed at $11.57; it most recently closed at $143.73 on October 5, 2026. The highest price in this record is $160.81, reached on August 17, 2026; the latest close is 10.6% below that peak. Across the 9 complete calendar years in the table, PTGX finished higher in 5 and lower in 4. Its best year was 2020 (+205.9%) and its worst was 2022 (-68.1%).
Over roughly 10 years the share price changed +1142.3%, a 28.2% compound annual price return (excluding dividends). In the last 12 months alone, PTGX has gained 114.4%. Prices are split-adjusted closing prices; daily open, high, low, close and volume for the past year are listed below.
Summary generated from market data by MetaCap's automated system. Methodology
Key price levels
- High since 2016
- $160.81
- Date of high
- Aug 17, 2026
- Low since 2016
- $4.47
- Date of low
- Dec 2, 2019
- 52-week high
- $160.81
- 52-week low
- $73.08
- IPO year
- 2016
- Last close
- $143.73
PTGX returns
1 week
+2.62%
1 month
-0.94%
3 months
+9.37%
6 months
+45.45%
Year to date
+64.56%
1 year
+114.39%
3 years
+830.89%
5 years
+364.09%
PTGX price return, excluding dividends.
PTGX annual returns
| Year | Year-end close | Return |
|---|---|---|
| 2026 | 143.73 | +64.87% |
| 2025 | 87.18 | +120.32% |
| 2024 | 39.57 | +72.57% |
| 2023 | 22.93 | +110.17% |
| 2022 | 10.91 | -68.10% |
| 2021 | 34.20 | +69.64% |
| 2020 | 20.16 | +205.92% |
| 2019 | 6.59 | -5.04% |
| 2018 | 6.94 | -66.63% |
| 2017 | 20.80 | -5.41% |
| 2016* | 21.99 | +90.06% |
* Partial year: the record begins after the start of 2016; return measured from the first available close.
2026 return is year to date.
PTGX daily prices (past year)
| Date | Open | High | Low | Close | Change |
|---|---|---|---|---|---|
| 139.92 | 146.30 | 138.95 | 143.73 | +2.73% | |
| 139.57 | 142.18 | 137.99 | 139.91 | -0.72% | |
| 137.34 | 144.10 | 137.25 | 140.92 | +1.61% | |
| 140.34 | 141.00 | 136.09 | 138.69 | -1.38% | |
| 139.96 | 142.51 | 138.08 | 140.63 | +0.41% | |
| 140.99 | 141.71 | 138.37 | 140.06 | +0.63% | |
| 139.23 | 143.68 | 138.37 | 139.19 | -1.21% | |
| 141.60 | 143.74 | 140.44 | 140.89 | -0.06% | |
| 143.45 | 144.09 | 138.88 | 140.97 | -1.03% | |
| 142.21 | 143.69 | 140.24 | 142.44 | +0.41% | |
| 141.81 | 143.45 | 138.23 | 141.86 | +3.29% | |
| 138.76 | 140.80 | 134.10 | 137.34 | -0.98% | |
| 144.27 | 145.28 | 137.88 | 138.70 | -4.39% | |
| 144.64 | 147.71 | 144.50 | 145.07 | +0.06% | |
| 143.22 | 145.37 | 141.09 | 144.98 | +1.38% | |
| 143.09 | 144.58 | 140.44 | 143.00 | -0.49% | |
| 144.39 | 146.50 | 142.31 | 143.70 | +0.60% | |
| 144.19 | 146.19 | 140.88 | 142.84 | -0.39% | |
| 147.48 | 147.99 | 142.00 | 143.40 | -2.96% | |
| 150.23 | 151.24 | 146.83 | 147.78 | -0.27% | |
| 147.18 | 150.48 | 145.82 | 148.18 | +2.08% | |
| 143.29 | 146.51 | 142.00 | 145.16 | +0.05% | |
| 146.05 | 151.19 | 144.46 | 145.09 | -0.58% | |
| 143.61 | 147.29 | 142.00 | 145.94 | +0.15% | |
| 146.47 | 147.99 | 144.01 | 145.72 | -2.07% | |
| 146.68 | 149.49 | 144.00 | 148.80 | +1.86% | |
| 148.00 | 149.42 | 144.61 | 146.08 | -0.28% | |
| 147.75 | 150.34 | 144.73 | 146.49 | -0.85% | |
| 143.26 | 149.30 | 141.95 | 147.75 | +2.37% | |
| 147.73 | 147.95 | 142.43 | 144.33 | -3.46% | |
| 150.35 | 151.68 | 147.11 | 149.50 | -1.32% | |
| 150.36 | 152.07 | 147.69 | 151.50 | +0.60% | |
| 155.84 | 157.98 | 150.09 | 150.59 | -2.67% | |
| 154.32 | 158.08 | 149.94 | 154.72 | +0.26% | |
| 152.10 | 154.95 | 150.82 | 154.32 | +2.41% | |
| 152.45 | 155.25 | 148.28 | 150.69 | -2.74% | |
| 160.81 | 160.81 | 154.22 | 154.94 | -1.53% | |
| 157.96 | 160.00 | 156.81 | 157.34 | -0.81% | |
| 155.11 | 158.95 | 153.60 | 158.62 | +2.27% | |
| 150.23 | 155.53 | 149.17 | 155.10 | +2.43% | |
| 153.15 | 154.99 | 150.92 | 151.42 | -0.39% | |
| 148.21 | 152.70 | 147.33 | 152.01 | +2.51% | |
| 151.88 | 151.88 | 147.37 | 148.29 | -1.14% | |
| 149.31 | 151.60 | 147.40 | 150.00 | +2.83% | |
| 146.18 | 147.32 | 144.44 | 145.87 | -0.21% | |
| 145.01 | 148.00 | 139.95 | 146.18 | +6.45% | |
| 137.49 | 138.08 | 135.39 | 137.32 | +1.11% | |
| 133.02 | 138.05 | 132.26 | 135.81 | +2.67% | |
| 135.78 | 135.98 | 131.68 | 132.28 | -3.19% | |
| 138.36 | 138.37 | 131.69 | 136.64 | -1.44% | |
| 131.77 | 138.95 | 130.63 | 138.64 | +4.24% | |
| 136.90 | 137.43 | 132.72 | 133.00 | -2.81% | |
| 136.69 | 137.00 | 133.20 | 136.84 | +0.94% | |
| 136.11 | 139.92 | 135.43 | 135.56 | -0.40% | |
| 136.11 | 137.20 | 133.78 | 136.11 | +0.50% | |
| 133.79 | 137.33 | 132.00 | 135.43 | -0.01% | |
| 139.45 | 139.45 | 134.42 | 135.44 | -2.08% | |
| 133.34 | 139.72 | 131.05 | 138.31 | +3.01% | |
| 141.79 | 143.29 | 133.64 | 134.27 | -4.71% | |
| 131.37 | 141.08 | 131.37 | 140.91 | +6.73% | |
| 135.21 | 136.56 | 131.35 | 132.02 | -2.54% | |
| 128.00 | 139.22 | 126.97 | 135.46 | +3.19% | |
| 131.89 | 131.95 | 128.68 | 131.27 | +1.06% | |
| 130.05 | 131.36 | 125.32 | 129.89 | -1.16% | |
| 137.12 | 137.12 | 130.64 | 131.42 | -4.52% | |
| 139.26 | 141.10 | 136.99 | 137.64 | -1.73% | |
| 139.50 | 140.95 | 136.08 | 140.07 | -0.55% | |
| 132.59 | 141.08 | 130.69 | 140.85 | +7.11% | |
| 131.25 | 132.79 | 128.15 | 131.50 | -0.09% | |
| 125.89 | 131.87 | 125.24 | 131.62 | +5.15% | |
| 122.96 | 126.04 | 122.48 | 125.17 | +2.11% | |
| 122.04 | 124.72 | 119.57 | 122.58 | +0.78% | |
| 121.34 | 126.59 | 118.27 | 121.63 | -0.21% | |
| 122.00 | 123.43 | 118.31 | 121.88 | -0.61% | |
| 122.31 | 126.25 | 121.48 | 122.63 | +0.39% | |
| 119.38 | 124.80 | 118.81 | 122.15 | +2.68% | |
| 114.66 | 119.85 | 114.56 | 118.96 | +3.42% | |
| 113.24 | 116.57 | 113.24 | 115.03 | +1.92% | |
| 112.88 | 114.49 | 111.17 | 112.86 | +1.27% | |
| 110.84 | 113.47 | 110.11 | 111.44 | +0.72% | |
| 112.83 | 113.66 | 108.53 | 110.64 | -1.62% | |
| 109.10 | 112.77 | 109.10 | 112.46 | +2.44% | |
| 109.85 | 111.78 | 109.60 | 109.78 | -0.01% | |
| 106.28 | 110.82 | 106.28 | 109.79 | +3.80% | |
| 105.50 | 111.45 | 104.89 | 105.77 | -0.09% | |
| 99.76 | 106.48 | 98.08 | 105.87 | +8.00% | |
| 98.95 | 101.16 | 96.70 | 98.03 | +0.67% | |
| 103.14 | 103.29 | 96.38 | 97.38 | -5.26% | |
| 96.39 | 103.55 | 96.14 | 102.79 | +7.74% | |
| 93.93 | 95.61 | 93.00 | 95.41 | +2.34% | |
| 93.84 | 97.71 | 92.75 | 93.23 | -1.78% | |
| 97.88 | 98.50 | 93.50 | 94.92 | -4.66% | |
| 100.64 | 102.40 | 98.84 | 99.56 | -0.85% | |
| 102.74 | 103.71 | 99.43 | 100.41 | -1.76% | |
| 100.05 | 102.49 | 98.94 | 102.21 | +2.23% | |
| 100.03 | 100.80 | 97.93 | 99.98 | +0.80% | |
| 102.01 | 102.42 | 98.89 | 99.19 | -2.76% | |
| 101.13 | 103.43 | 98.60 | 102.01 | +1.12% | |
| 99.03 | 101.90 | 98.37 | 100.88 | +2.55% | |
| 100.25 | 100.26 | 96.69 | 98.37 | -2.35% | |
| 103.22 | 104.16 | 100.58 | 100.74 | -1.41% | |
| 104.22 | 104.39 | 101.72 | 102.18 | -3.19% | |
| 104.31 | 105.72 | 101.62 | 105.55 | +1.61% | |
| 99.58 | 104.20 | 98.22 | 103.88 | +3.93% | |
| 103.50 | 103.66 | 98.36 | 99.95 | -3.43% | |
| 100.14 | 105.33 | 99.94 | 103.50 | +4.17% | |
| 98.51 | 100.15 | 97.00 | 99.36 | +0.52% | |
| 103.55 | 104.68 | 98.53 | 98.85 | -4.92% | |
| 103.00 | 105.03 | 98.95 | 103.97 | +4.80% | |
| 100.32 | 101.37 | 97.45 | 99.21 | -0.31% | |
| 98.00 | 101.08 | 98.00 | 99.52 | +1.17% | |
| 99.16 | 99.47 | 97.08 | 98.37 | -0.61% | |
| 99.00 | 99.76 | 97.20 | 98.97 | +0.46% | |
| 100.27 | 100.35 | 98.11 | 98.52 | -2.66% | |
| 99.50 | 102.47 | 97.79 | 101.21 | +2.74% | |
| 100.44 | 103.42 | 98.31 | 98.51 | -1.49% | |
| 102.54 | 105.94 | 98.91 | 100.00 | -2.55% | |
| 106.34 | 106.98 | 102.26 | 102.62 | -2.78% | |
| 106.43 | 107.00 | 103.93 | 105.55 | -0.32% | |
| 104.94 | 106.45 | 103.64 | 105.89 | +0.40% | |
| 105.47 | 106.46 | 104.00 | 105.47 | -0.48% | |
| 105.57 | 106.90 | 103.51 | 105.98 | +2.17% | |
| 103.59 | 104.53 | 102.46 | 103.73 | -1.62% | |
| 105.96 | 106.66 | 103.02 | 105.44 | +0.69% | |
| 97.58 | 104.97 | 97.58 | 104.72 | +7.33% | |
| 98.61 | 101.04 | 95.40 | 97.57 | -1.26% | |
| 104.28 | 104.28 | 98.40 | 98.82 | -5.06% | |
| 101.45 | 105.11 | 101.45 | 104.09 | +1.95% | |
| 104.28 | 105.88 | 101.62 | 102.09 | -1.60% | |
| 103.43 | 103.96 | 101.31 | 103.75 | +0.84% | |
| 103.72 | 104.46 | 101.84 | 102.89 | -0.86% | |
| 101.59 | 104.31 | 101.59 | 103.78 | +0.11% | |
| 105.51 | 107.84 | 102.70 | 103.67 | -1.64% | |
| 101.23 | 105.99 | 101.06 | 105.40 | +5.54% | |
| 99.04 | 102.76 | 98.08 | 99.87 | +0.91% | |
| 101.27 | 101.92 | 97.89 | 98.97 | -3.13% | |
| 103.25 | 105.69 | 102.01 | 102.17 | -2.05% | |
| 99.42 | 105.00 | 97.16 | 104.31 | +3.90% | |
| 97.16 | 100.98 | 97.16 | 100.39 | +1.88% | |
| 100.00 | 102.06 | 98.15 | 98.54 | -0.33% | |
| 101.47 | 101.80 | 97.83 | 98.87 | -2.76% | |
| 98.45 | 105.69 | 98.35 | 101.68 | +4.73% | |
| 97.04 | 99.50 | 90.58 | 97.09 | -0.14% | |
| 96.70 | 99.31 | 96.43 | 97.23 | +0.50% | |
| 93.28 | 97.08 | 92.61 | 96.75 | +4.75% | |
| 96.91 | 98.30 | 90.92 | 92.36 | -3.21% | |
| 95.01 | 96.39 | 93.67 | 95.42 | -1.10% | |
| 96.84 | 98.32 | 95.97 | 96.48 | -0.59% | |
| 96.02 | 98.21 | 95.40 | 97.05 | +0.40% | |
| 91.14 | 97.54 | 91.14 | 96.66 | +4.96% | |
| 89.96 | 92.97 | 87.82 | 92.09 | +0.74% | |
| 94.54 | 94.54 | 90.35 | 91.41 | -3.61% | |
| 91.94 | 95.43 | 91.03 | 94.83 | +3.87% | |
| 92.56 | 93.51 | 90.02 | 91.30 | -3.12% | |
| 92.08 | 94.89 | 90.99 | 94.24 | +2.35% | |
| 88.18 | 92.23 | 87.15 | 92.08 | +4.17% | |
| 87.50 | 88.83 | 85.60 | 88.39 | +1.48% | |
| 87.50 | 88.46 | 86.26 | 87.10 | -0.33% | |
| 86.72 | 89.59 | 86.00 | 87.39 | +0.92% | |
| 82.32 | 86.85 | 77.00 | 86.59 | +4.63% | |
| 83.26 | 83.69 | 80.72 | 82.76 | -0.40% | |
| 81.88 | 83.22 | 80.59 | 83.09 | +0.12% | |
| 81.59 | 83.40 | 81.59 | 82.99 | +0.64% | |
| 81.07 | 83.13 | 80.40 | 82.46 | +1.19% | |
| 81.99 | 84.06 | 80.59 | 81.49 | -0.54% | |
| 84.07 | 84.72 | 81.56 | 81.93 | -1.87% | |
| 83.46 | 84.82 | 80.99 | 83.49 | -0.46% | |
| 83.00 | 84.90 | 82.65 | 83.88 | +0.67% | |
| 83.47 | 83.90 | 82.21 | 83.32 | -1.38% | |
| 82.11 | 85.05 | 81.55 | 84.49 | +4.74% | |
| 83.62 | 85.43 | 80.20 | 80.67 | -3.16% | |
| 85.59 | 85.60 | 81.00 | 83.30 | -2.68% | |
| 83.09 | 86.10 | 82.88 | 85.59 | +3.06% | |
| 81.80 | 84.55 | 81.14 | 83.05 | +1.53% | |
| 79.77 | 82.56 | 78.75 | 81.80 | +2.60% | |
| 81.39 | 82.49 | 77.70 | 79.73 | -2.48% | |
| 82.45 | 83.69 | 80.00 | 81.76 | -1.59% | |
| 82.00 | 83.87 | 82.00 | 83.08 | +0.95% | |
| 82.53 | 84.32 | 81.94 | 82.30 | -0.96% | |
| 84.62 | 85.50 | 82.67 | 83.10 | -1.99% | |
| 82.83 | 85.20 | 80.65 | 84.79 | +1.07% | |
| 82.51 | 83.96 | 80.27 | 83.89 | +0.56% | |
| 81.16 | 83.63 | 79.87 | 83.42 | +1.74% | |
| 84.51 | 84.67 | 81.47 | 81.99 | -3.26% | |
| 84.60 | 87.44 | 84.33 | 84.75 | -0.56% | |
| 80.85 | 85.30 | 80.47 | 85.23 | +4.76% | |
| 79.88 | 82.74 | 79.64 | 81.36 | +1.38% | |
| 79.49 | 81.09 | 78.75 | 80.25 | +0.04% | |
| 80.20 | 81.40 | 79.38 | 80.22 | +0.02% | |
| 81.05 | 82.14 | 79.22 | 80.20 | -2.60% | |
| 82.25 | 82.69 | 79.18 | 82.34 | +0.09% | |
| 83.25 | 85.00 | 81.67 | 82.27 | -2.27% | |
| 87.53 | 87.53 | 82.92 | 84.18 | -3.44% | |
| 86.54 | 88.16 | 85.19 | 87.18 | -0.18% | |
| 87.32 | 88.23 | 85.98 | 87.34 | +0.09% | |
| 87.94 | 88.32 | 86.12 | 87.26 | -0.76% | |
| 88.66 | 89.10 | 87.30 | 87.93 | -0.96% | |
| 88.78 | 89.61 | 87.47 | 88.78 | -0.07% | |
| 88.53 | 89.47 | 87.47 | 88.84 | +0.12% | |
| 87.27 | 90.00 | 87.27 | 88.73 | +1.51% | |
| 85.33 | 88.13 | 84.88 | 87.41 | +1.58% | |
| 86.58 | 87.73 | 84.81 | 86.05 | +0.30% | |
| 89.35 | 90.02 | 84.11 | 85.79 | -3.97% | |
| 91.41 | 92.54 | 88.38 | 89.34 | -2.40% | |
| 93.93 | 94.54 | 90.18 | 91.54 | -3.43% | |
| 95.41 | 96.54 | 94.17 | 94.79 | -0.59% | |
| 92.72 | 95.39 | 91.70 | 95.35 | +3.36% | |
| 92.01 | 93.07 | 91.07 | 92.25 | +0.95% | |
| 88.56 | 91.96 | 88.34 | 91.38 | +3.18% | |
| 89.73 | 92.80 | 88.30 | 88.56 | -1.87% | |
| 90.94 | 91.89 | 89.51 | 90.25 | +0.67% | |
| 87.96 | 90.18 | 87.54 | 89.65 | +2.66% | |
| 86.07 | 88.10 | 85.13 | 87.33 | +1.46% | |
| 85.43 | 87.10 | 84.73 | 86.07 | +1.68% | |
| 85.75 | 86.39 | 83.52 | 84.65 | -1.16% | |
| 89.61 | 89.85 | 85.00 | 85.64 | -4.84% | |
| 90.00 | 90.46 | 88.78 | 90.00 | -0.08% | |
| 90.00 | 90.85 | 89.50 | 90.07 | +0.23% | |
| 88.46 | 89.88 | 87.76 | 89.86 | +2.47% | |
| 86.59 | 88.34 | 85.71 | 87.69 | +2.68% | |
| 84.24 | 86.67 | 83.64 | 85.40 | +1.43% | |
| 86.36 | 86.95 | 84.00 | 84.20 | -1.09% | |
| 84.54 | 86.65 | 84.45 | 85.13 | +0.88% | |
| 84.77 | 86.36 | 83.79 | 84.39 | -0.45% | |
| 82.79 | 85.45 | 82.79 | 84.77 | +0.19% | |
| 82.18 | 85.90 | 82.06 | 84.61 | +1.65% | |
| 84.84 | 86.02 | 83.17 | 83.24 | -1.90% | |
| 85.41 | 86.90 | 84.50 | 84.85 | -0.83% | |
| 83.52 | 86.00 | 83.00 | 85.56 | +2.80% | |
| 80.58 | 84.84 | 79.56 | 83.23 | +4.64% | |
| 80.12 | 80.75 | 76.70 | 79.54 | -0.30% | |
| 77.07 | 79.92 | 77.00 | 79.78 | +2.44% | |
| 76.50 | 78.12 | 75.55 | 77.88 | +1.80% | |
| 75.44 | 78.01 | 75.44 | 76.50 | +0.72% | |
| 78.62 | 80.43 | 75.54 | 75.95 | -3.40% | |
| 77.53 | 79.01 | 76.66 | 78.62 | +0.99% | |
| 77.21 | 78.74 | 76.75 | 77.85 | +1.51% | |
| 78.06 | 79.00 | 76.49 | 76.69 | -2.32% | |
| 75.06 | 78.78 | 74.80 | 78.51 | +4.33% | |
| 75.13 | 76.08 | 74.03 | 75.25 | +0.52% | |
| 74.13 | 75.53 | 73.84 | 74.86 | +1.18% | |
| 73.37 | 74.91 | 73.08 | 73.99 | +0.66% | |
| 74.51 | 74.95 | 73.29 | 73.50 | -2.00% | |
| 76.51 | 77.22 | 74.78 | 75.00 | -2.24% | |
| 77.51 | 77.66 | 75.51 | 76.72 | -1.01% | |
| 75.60 | 77.58 | 75.17 | 77.50 | +2.34% | |
| 77.81 | 78.00 | 74.62 | 75.73 | -2.51% | |
| 75.29 | 78.15 | 75.29 | 77.68 | +0.96% | |
| 78.49 | 78.49 | 76.00 | 76.94 | -2.82% | |
| 85.28 | 86.76 | 75.04 | 79.17 | -9.00% | |
| 67.39 | 93.25 | 65.75 | 87.00 | +29.77% | |
| 65.56 | 67.57 | 65.56 | 67.04 | — |
Prices are adjusted for stock splits. See adjusted closing price for how dividends and splits affect history, and the PTGX chart for longer ranges.