Pyxis Oncology Stock Price History
NASDAQ: PYXSHealth CareBiotechnology: Pharmaceutical PreparationsUSD
2.03+0.04 (+2.01%)
At close: Oct 9, 4:00 PM ET · Delayed 15 min
PYXS price history at a glance
The price history for Pyxis Oncology (PYXS) on this page begins on October 4, 2021, when the stock closed at $13.20; it most recently closed at $2.03 on October 5, 2026. The highest price in this record is $19.00, reached on October 4, 2021; the latest close is 89.3% below that peak. Across the 4 complete calendar years in the table, PYXS finished higher in 1 and lower in 3. Its best year was 2023 (+34.3%) and its worst was 2022 (-87.8%).
Over roughly 5 years the share price changed -84.6%, a -31.2% compound annual price return (excluding dividends). In the last 12 months alone, PYXS has lost 47.0%. Prices are split-adjusted closing prices; daily open, high, low, close and volume for the past year are listed below.
Summary generated from market data by MetaCap's automated system. Methodology
Key price levels
- High since 2021
- $19.00
- Date of high
- Oct 4, 2021
- Low since 2021
- $0.833
- Date of low
- Apr 7, 2025
- 52-week high
- $5.55
- 52-week low
- $1.03
- IPO year
- 2021
- Last close
- $2.03
PYXS returns
1 week
-5.14%
1 month
-39.94%
3 months
-23.97%
6 months
+19.41%
Year to date
+76.52%
1 year
-47.00%
3 years
+1.50%
5 years
-82.75%
PYXS price return, excluding dividends.
PYXS annual returns
| Year | Year-end close | Return |
|---|---|---|
| 2026 | 2.03 | +76.52% |
| 2025 | 1.15 | -32.35% |
| 2024 | 1.70 | -5.56% |
| 2023 | 1.80 | +34.33% |
| 2022 | 1.34 | -87.78% |
| 2021* | 10.97 | -16.89% |
* Partial year: the record begins after the start of 2021; return measured from the first available close.
2026 return is year to date.
PYXS daily prices (past year)
| Date | Open | High | Low | Close | Change |
|---|---|---|---|---|---|
| 1.99 | 2.06 | 1.98 | 2.03 | +2.01% | |
| 2.03 | 2.03 | 1.90 | 1.99 | -1.00% | |
| 2.02 | 2.09 | 2.00 | 2.01 | -0.50% | |
| 2.22 | 2.22 | 2.00 | 2.02 | -9.82% | |
| 2.12 | 2.26 | 2.05 | 2.24 | +4.67% | |
| 2.21 | 2.31 | 2.10 | 2.14 | -2.28% | |
| 2.31 | 2.31 | 2.19 | 2.19 | -6.01% | |
| 2.38 | 2.41 | 2.12 | 2.33 | -19.66% | |
| 2.94 | 2.94 | 2.83 | 2.90 | 0.00% | |
| 2.81 | 2.91 | 2.75 | 2.90 | +1.40% | |
| 2.91 | 2.92 | 2.79 | 2.86 | -2.05% | |
| 3.22 | 3.25 | 2.86 | 2.92 | -9.32% | |
| 3.36 | 3.36 | 3.20 | 3.22 | -4.02% | |
| 3.21 | 3.41 | 3.19 | 3.36 | +5.17% | |
| 3.38 | 3.38 | 3.19 | 3.19 | -4.20% | |
| 3.38 | 3.44 | 3.33 | 3.33 | -2.35% | |
| 3.43 | 3.47 | 3.34 | 3.41 | +2.10% | |
| 3.34 | 3.42 | 3.32 | 3.34 | +0.30% | |
| 3.40 | 3.42 | 3.24 | 3.33 | -2.92% | |
| 3.21 | 3.52 | 3.21 | 3.43 | +6.85% | |
| 3.31 | 3.42 | 3.07 | 3.21 | -1.83% | |
| 3.42 | 3.44 | 3.18 | 3.27 | -3.25% | |
| 3.48 | 4.12 | 3.13 | 3.38 | -13.11% | |
| 4.00 | 4.15 | 3.85 | 3.89 | 0.00% | |
| 3.53 | 4.05 | 3.52 | 3.89 | +9.12% | |
| 3.71 | 3.74 | 3.45 | 3.57 | -4.93% | |
| 3.45 | 3.77 | 3.44 | 3.75 | +9.01% | |
| 3.24 | 3.57 | 3.18 | 3.44 | +6.17% | |
| 3.20 | 3.28 | 3.05 | 3.24 | +0.31% | |
| 3.32 | 3.38 | 3.20 | 3.23 | -2.71% | |
| 3.31 | 3.37 | 3.23 | 3.32 | -0.60% | |
| 3.03 | 3.36 | 3.00 | 3.34 | +9.15% | |
| 2.96 | 3.09 | 2.94 | 3.06 | +3.38% | |
| 3.02 | 3.07 | 2.83 | 2.96 | -3.90% | |
| 3.15 | 3.21 | 3.02 | 3.08 | -1.28% | |
| 3.30 | 3.39 | 3.03 | 3.12 | -7.42% | |
| 3.07 | 3.50 | 3.06 | 3.37 | +12.71% | |
| 3.03 | 3.13 | 2.97 | 2.99 | -0.99% | |
| 3.03 | 3.09 | 2.83 | 3.02 | +0.33% | |
| 2.99 | 3.08 | 2.86 | 3.01 | 0.00% | |
| 2.95 | 3.35 | 2.75 | 3.01 | -5.35% | |
| 2.76 | 3.21 | 2.72 | 3.18 | +12.37% | |
| 3.85 | 4.00 | 1.90 | 2.83 | -26.11% | |
| 3.72 | 3.99 | 3.72 | 3.83 | +2.68% | |
| 3.78 | 3.90 | 3.62 | 3.73 | -0.53% | |
| 3.14 | 3.77 | 3.13 | 3.75 | +19.81% | |
| 3.20 | 3.32 | 3.07 | 3.13 | -0.95% | |
| 3.02 | 3.25 | 3.02 | 3.16 | +3.95% | |
| 2.70 | 3.05 | 2.70 | 3.04 | +14.72% | |
| 2.84 | 2.85 | 2.63 | 2.65 | -7.67% | |
| 2.95 | 3.00 | 2.81 | 2.87 | -1.71% | |
| 2.90 | 3.09 | 2.89 | 2.92 | +0.34% | |
| 2.90 | 3.05 | 2.74 | 2.91 | 0.00% | |
| 2.64 | 2.99 | 2.62 | 2.91 | +11.49% | |
| 2.72 | 2.83 | 2.60 | 2.61 | -2.61% | |
| 2.59 | 2.78 | 2.49 | 2.68 | +5.93% | |
| 2.24 | 2.56 | 2.13 | 2.53 | +13.45% | |
| 2.25 | 2.30 | 2.20 | 2.23 | -0.89% | |
| 2.35 | 2.42 | 2.23 | 2.25 | -4.66% | |
| 2.23 | 2.39 | 2.18 | 2.36 | +5.83% | |
| 2.40 | 2.40 | 2.22 | 2.23 | -8.23% | |
| 2.30 | 2.47 | 2.27 | 2.43 | +6.11% | |
| 2.45 | 2.45 | 2.23 | 2.29 | -6.15% | |
| 2.65 | 2.68 | 2.42 | 2.44 | -8.61% | |
| 2.64 | 2.69 | 2.40 | 2.67 | +1.14% | |
| 2.69 | 2.81 | 2.59 | 2.64 | -1.86% | |
| 3.03 | 3.07 | 2.63 | 2.69 | -12.38% | |
| 2.47 | 3.20 | 2.37 | 3.07 | +24.80% | |
| 2.65 | 2.69 | 2.37 | 2.46 | -6.46% | |
| 2.79 | 3.00 | 2.63 | 2.63 | -7.72% | |
| 3.01 | 3.19 | 2.83 | 2.85 | -5.32% | |
| 2.49 | 3.40 | 2.43 | 3.01 | +5.24% | |
| 2.73 | 2.92 | 2.62 | 2.86 | +3.25% | |
| 2.24 | 3.00 | 2.20 | 2.77 | +24.22% | |
| 2.19 | 2.30 | 2.12 | 2.23 | +2.76% | |
| 2.09 | 2.31 | 2.05 | 2.17 | +3.33% | |
| 2.08 | 2.26 | 2.07 | 2.10 | -1.41% | |
| 1.98 | 2.18 | 1.95 | 2.13 | +4.93% | |
| 1.90 | 2.07 | 1.90 | 2.03 | +6.84% | |
| 1.78 | 1.96 | 1.78 | 1.90 | +8.57% | |
| 1.74 | 1.80 | 1.66 | 1.75 | +0.57% | |
| 1.76 | 1.83 | 1.66 | 1.74 | -1.14% | |
| 1.69 | 1.87 | 1.68 | 1.76 | +5.39% | |
| 1.67 | 1.73 | 1.54 | 1.67 | 0.00% | |
| 1.70 | 1.80 | 1.67 | 1.67 | -1.76% | |
| 1.68 | 1.78 | 1.64 | 1.70 | +0.59% | |
| 1.84 | 1.84 | 1.68 | 1.69 | -5.06% | |
| 1.71 | 1.87 | 1.62 | 1.78 | +4.09% | |
| 1.70 | 1.78 | 1.66 | 1.71 | +0.59% | |
| 1.73 | 1.75 | 1.67 | 1.70 | -0.58% | |
| 1.78 | 1.78 | 1.66 | 1.71 | -4.47% | |
| 1.78 | 1.84 | 1.72 | 1.79 | -0.56% | |
| 1.76 | 1.88 | 1.72 | 1.80 | +1.12% | |
| 1.73 | 1.83 | 1.64 | 1.78 | +2.89% | |
| 1.60 | 1.79 | 1.60 | 1.73 | +6.13% | |
| 2.00 | 2.04 | 1.57 | 1.63 | -16.84% | |
| 1.95 | 2.02 | 1.73 | 1.96 | +1.03% | |
| 2.01 | 2.08 | 1.93 | 1.94 | -3.00% | |
| 1.92 | 2.09 | 1.88 | 2.00 | +4.71% | |
| 2.00 | 2.01 | 1.90 | 1.91 | -5.45% | |
| 2.23 | 2.28 | 2.01 | 2.02 | -11.40% | |
| 2.21 | 2.35 | 1.95 | 2.28 | +3.17% | |
| 2.65 | 2.65 | 2.08 | 2.21 | -15.65% | |
| 2.59 | 2.73 | 2.56 | 2.62 | +0.77% | |
| 2.74 | 2.78 | 2.51 | 2.60 | -5.45% | |
| 2.66 | 2.92 | 2.66 | 2.75 | +0.36% | |
| 2.27 | 2.77 | 2.24 | 2.74 | +21.24% | |
| 2.30 | 2.33 | 2.18 | 2.26 | -1.74% | |
| 1.85 | 2.37 | 1.82 | 2.30 | +25.68% | |
| 1.88 | 1.96 | 1.71 | 1.83 | +3.98% | |
| 1.71 | 1.81 | 1.70 | 1.76 | +2.33% | |
| 1.71 | 1.73 | 1.67 | 1.72 | +1.18% | |
| 1.65 | 1.75 | 1.62 | 1.70 | +2.41% | |
| 1.70 | 1.73 | 1.64 | 1.66 | -2.35% | |
| 1.76 | 1.87 | 1.68 | 1.70 | -3.41% | |
| 1.91 | 1.98 | 1.72 | 1.76 | -7.37% | |
| 1.74 | 1.98 | 1.74 | 1.90 | +11.11% | |
| 1.89 | 1.91 | 1.71 | 1.71 | -9.04% | |
| 1.73 | 1.94 | 1.69 | 1.88 | +9.94% | |
| 1.70 | 1.73 | 1.64 | 1.71 | +0.59% | |
| 1.65 | 1.73 | 1.62 | 1.70 | +2.41% | |
| 1.72 | 1.75 | 1.65 | 1.66 | -2.35% | |
| 1.70 | 1.72 | 1.66 | 1.70 | -0.58% | |
| 1.68 | 1.75 | 1.61 | 1.71 | +0.59% | |
| 1.72 | 1.84 | 1.69 | 1.70 | -0.58% | |
| 1.70 | 1.75 | 1.60 | 1.71 | +0.59% | |
| 1.61 | 1.74 | 1.60 | 1.70 | +5.59% | |
| 1.46 | 1.62 | 1.43 | 1.61 | +9.52% | |
| 1.48 | 1.51 | 1.42 | 1.47 | +0.68% | |
| 1.44 | 1.48 | 1.41 | 1.46 | +0.69% | |
| 1.48 | 1.53 | 1.43 | 1.45 | -2.03% | |
| 1.43 | 1.50 | 1.40 | 1.48 | +0.68% | |
| 1.45 | 1.55 | 1.45 | 1.47 | +0.68% | |
| 1.33 | 1.46 | 1.31 | 1.46 | +14.96% | |
| 1.31 | 1.33 | 1.26 | 1.27 | -3.05% | |
| 1.35 | 1.38 | 1.28 | 1.31 | -5.76% | |
| 1.42 | 1.45 | 1.37 | 1.39 | -2.80% | |
| 1.37 | 1.46 | 1.36 | 1.43 | +5.15% | |
| 1.44 | 1.47 | 1.35 | 1.36 | -4.23% | |
| 1.50 | 1.52 | 1.36 | 1.42 | -3.40% | |
| 1.54 | 1.58 | 1.47 | 1.47 | -4.55% | |
| 1.50 | 1.56 | 1.48 | 1.54 | +0.65% | |
| 1.61 | 1.70 | 1.52 | 1.53 | -5.56% | |
| 1.67 | 1.68 | 1.58 | 1.62 | -2.99% | |
| 1.57 | 1.69 | 1.54 | 1.67 | +8.44% | |
| 1.54 | 1.60 | 1.51 | 1.54 | +0.65% | |
| 1.54 | 1.57 | 1.46 | 1.53 | -1.92% | |
| 1.56 | 1.57 | 1.48 | 1.56 | +0.65% | |
| 1.47 | 1.61 | 1.47 | 1.55 | +3.33% | |
| 1.37 | 1.51 | 1.35 | 1.50 | +9.49% | |
| 1.36 | 1.39 | 1.33 | 1.37 | +1.48% | |
| 1.47 | 1.47 | 1.34 | 1.35 | -9.40% | |
| 1.45 | 1.52 | 1.42 | 1.49 | +4.20% | |
| 1.42 | 1.48 | 1.40 | 1.43 | -2.72% | |
| 1.40 | 1.48 | 1.39 | 1.47 | 0.00% | |
| 1.49 | 1.52 | 1.46 | 1.47 | -3.29% | |
| 1.52 | 1.54 | 1.44 | 1.52 | 0.00% | |
| 1.50 | 1.54 | 1.46 | 1.52 | +2.70% | |
| 1.45 | 1.52 | 1.43 | 1.48 | +2.07% | |
| 1.40 | 1.46 | 1.39 | 1.45 | +2.11% | |
| 1.52 | 1.54 | 1.41 | 1.42 | -7.19% | |
| 1.37 | 1.54 | 1.34 | 1.53 | +11.68% | |
| 1.33 | 1.39 | 1.33 | 1.37 | +3.01% | |
| 1.30 | 1.35 | 1.27 | 1.33 | +2.31% | |
| 1.34 | 1.39 | 1.30 | 1.30 | -3.70% | |
| 1.34 | 1.37 | 1.29 | 1.35 | 0.00% | |
| 1.36 | 1.37 | 1.28 | 1.35 | -2.88% | |
| 1.35 | 1.42 | 1.35 | 1.39 | +1.46% | |
| 1.52 | 1.55 | 1.34 | 1.37 | -9.27% | |
| 1.55 | 1.69 | 1.51 | 1.51 | -1.95% | |
| 1.51 | 1.61 | 1.50 | 1.54 | +1.99% | |
| 1.49 | 1.53 | 1.38 | 1.51 | +1.34% | |
| 1.51 | 1.64 | 1.49 | 1.49 | -2.61% | |
| 1.44 | 1.61 | 1.44 | 1.53 | +5.52% | |
| 1.53 | 1.55 | 1.43 | 1.45 | -7.05% | |
| 1.50 | 1.59 | 1.49 | 1.56 | +3.31% | |
| 1.63 | 1.64 | 1.51 | 1.51 | -7.93% | |
| 1.61 | 1.68 | 1.58 | 1.64 | +1.86% | |
| 1.65 | 1.66 | 1.59 | 1.61 | -1.23% | |
| 1.71 | 1.72 | 1.60 | 1.63 | -4.68% | |
| 1.67 | 1.76 | 1.64 | 1.71 | +3.01% | |
| 1.66 | 1.74 | 1.60 | 1.66 | 0.00% | |
| 1.71 | 1.75 | 1.62 | 1.66 | -5.68% | |
| 1.85 | 2.00 | 1.67 | 1.76 | -4.35% | |
| 2.00 | 2.00 | 1.80 | 1.84 | -7.54% | |
| 1.91 | 2.03 | 1.82 | 1.99 | +5.85% | |
| 2.06 | 2.07 | 1.85 | 1.88 | -8.74% | |
| 1.76 | 2.17 | 1.70 | 2.06 | +17.05% | |
| 1.47 | 1.81 | 1.47 | 1.76 | +21.38% | |
| 1.44 | 1.46 | 1.35 | 1.45 | +2.11% | |
| 1.30 | 1.52 | 1.29 | 1.42 | +9.23% | |
| 1.22 | 1.34 | 1.20 | 1.30 | +7.44% | |
| 1.15 | 1.23 | 1.14 | 1.21 | +5.22% | |
| 1.18 | 1.21 | 1.13 | 1.15 | 0.00% | |
| 1.12 | 1.20 | 1.09 | 1.15 | +5.50% | |
| 1.06 | 1.18 | 1.06 | 1.09 | +2.83% | |
| 1.11 | 1.15 | 1.04 | 1.06 | -4.50% | |
| 1.13 | 1.15 | 1.03 | 1.11 | 0.00% | |
| 1.10 | 1.16 | 1.08 | 1.11 | +1.83% | |
| 1.19 | 1.26 | 1.05 | 1.09 | -8.40% | |
| 1.31 | 1.39 | 1.16 | 1.19 | -6.67% | |
| 1.75 | 1.80 | 1.23 | 1.28 | -26.30% | |
| 1.70 | 1.91 | 1.48 | 1.73 | -48.66% | |
| 4.01 | 4.03 | 3.35 | 3.37 | -15.75% | |
| 4.17 | 4.17 | 3.85 | 4.00 | -4.76% | |
| 4.30 | 4.49 | 4.18 | 4.20 | -2.33% | |
| 4.40 | 4.58 | 4.25 | 4.30 | -2.49% | |
| 4.28 | 4.42 | 4.17 | 4.41 | +2.80% | |
| 4.30 | 4.34 | 4.10 | 4.29 | -0.23% | |
| 4.16 | 4.35 | 4.13 | 4.30 | +2.87% | |
| 4.21 | 4.30 | 4.11 | 4.18 | -0.95% | |
| 4.34 | 4.42 | 4.18 | 4.22 | -2.31% | |
| 4.52 | 4.59 | 4.25 | 4.32 | -6.09% | |
| 3.82 | 4.61 | 3.81 | 4.60 | +17.65% | |
| 4.37 | 4.39 | 3.67 | 3.91 | -10.93% | |
| 5.10 | 5.13 | 4.39 | 4.39 | -15.41% | |
| 5.30 | 5.42 | 5.10 | 5.19 | -1.70% | |
| 5.35 | 5.55 | 5.27 | 5.28 | -1.12% | |
| 5.18 | 5.37 | 5.03 | 5.34 | +3.69% | |
| 5.05 | 5.24 | 4.92 | 5.15 | +7.29% | |
| 4.51 | 4.99 | 4.51 | 4.80 | +5.96% | |
| 4.67 | 5.11 | 4.51 | 4.53 | -0.88% | |
| 4.68 | 4.78 | 4.47 | 4.57 | -3.18% | |
| 4.62 | 4.86 | 4.48 | 4.72 | +1.51% | |
| 4.36 | 4.73 | 4.27 | 4.65 | +6.65% | |
| 4.39 | 4.61 | 4.23 | 4.36 | -2.68% | |
| 4.34 | 4.64 | 4.33 | 4.48 | +2.52% | |
| 4.52 | 4.54 | 4.18 | 4.37 | -4.38% | |
| 4.78 | 4.80 | 4.50 | 4.57 | -4.19% | |
| 3.96 | 4.79 | 3.96 | 4.77 | +21.99% | |
| 4.02 | 4.03 | 3.72 | 3.91 | -3.22% | |
| 3.91 | 4.15 | 3.88 | 4.04 | +3.32% | |
| 4.00 | 4.02 | 3.83 | 3.91 | +0.26% | |
| 3.84 | 4.17 | 3.60 | 3.90 | +2.36% | |
| 3.48 | 4.15 | 3.48 | 3.81 | +7.02% | |
| 3.42 | 3.70 | 3.33 | 3.56 | +4.09% | |
| 3.30 | 3.44 | 3.28 | 3.42 | +3.32% | |
| 3.39 | 3.49 | 3.28 | 3.31 | -2.65% | |
| 3.38 | 3.49 | 3.26 | 3.40 | +0.29% | |
| 3.46 | 3.55 | 3.17 | 3.39 | -2.02% | |
| 3.43 | 3.55 | 3.40 | 3.46 | +2.37% | |
| 3.43 | 3.55 | 3.33 | 3.38 | -3.15% | |
| 3.53 | 3.57 | 3.23 | 3.49 | -2.51% | |
| 3.57 | 3.75 | 3.45 | 3.58 | 0.00% | |
| 3.40 | 3.75 | 3.40 | 3.58 | +6.55% | |
| 3.45 | 3.45 | 3.26 | 3.36 | +0.30% | |
| 3.60 | 3.82 | 3.34 | 3.35 | -8.47% | |
| 3.25 | 3.68 | 3.25 | 3.66 | +13.31% | |
| 3.42 | 3.45 | 3.18 | 3.23 | -6.38% | |
| 3.62 | 3.67 | 3.15 | 3.45 | -6.76% | |
| 3.83 | 3.89 | 3.45 | 3.70 | -3.39% | |
| 2.91 | 3.85 | 2.91 | 3.83 | — |
Prices are adjusted for stock splits. See adjusted closing price for how dividends and splits affect history, and the PYXS chart for longer ranges.