Spero Therapeutics Stock Price History
NASDAQ: SPROHealth CareBiotechnology: Pharmaceutical PreparationsUSD
1.20+0.06 (+5.26%)
At close: Oct 9, 4:00 PM ET · Delayed 15 min
SPRO price history at a glance
The price history for Spero Therapeutics (SPRO) on this page begins on October 30, 2017, when the stock closed at $11.56; it most recently closed at $1.20 on October 5, 2026. The highest price in this record is $23.64, reached on December 28, 2020; the latest close is 94.9% below that peak. Across the 8 complete calendar years in the table, SPRO finished higher in 3 and lower in 5. Its best year was 2025 (+113.6%) and its worst was 2022 (-89.2%).
Over roughly 9 years the share price changed -89.6%, a -22.4% compound annual price return (excluding dividends). In the last 12 months alone, SPRO has lost 49.2%. Prices are split-adjusted closing prices; daily open, high, low, close and volume for the past year are listed below.
Summary generated from market data by MetaCap's automated system. Methodology
Key price levels
- High since 2017
- $23.64
- Date of high
- Dec 28, 2020
- Low since 2017
- $0.505
- Date of low
- Apr 7, 2025
- 52-week high
- $3.08
- 52-week low
- $1.08
- IPO year
- 2017
- Last close
- $1.20
SPRO returns
1 week
+0.84%
1 month
+2.56%
3 months
-42.86%
6 months
-55.06%
Year to date
-48.50%
1 year
-49.15%
3 years
+6.19%
5 years
-92.95%
SPRO price return, excluding dividends.
SPRO annual returns
| Year | Year-end close | Return |
|---|---|---|
| 2026 | 1.20 | -48.94% |
| 2025 | 2.35 | +113.64% |
| 2024 | 1.10 | -25.17% |
| 2023 | 1.47 | -15.03% |
| 2022 | 1.73 | -89.19% |
| 2021 | 16.01 | -17.43% |
| 2020 | 19.39 | +102.40% |
| 2019 | 9.58 | +41.93% |
| 2018 | 6.75 | -42.55% |
| 2017* | 11.75 | +1.64% |
* Partial year: the record begins after the start of 2017; return measured from the first available close.
2026 return is year to date.
SPRO daily prices (past year)
| Date | Open | High | Low | Close | Change |
|---|---|---|---|---|---|
| 1.14 | 1.21 | 1.13 | 1.20 | +5.26% | |
| 1.20 | 1.22 | 1.13 | 1.14 | -2.56% | |
| 1.19 | 1.19 | 1.16 | 1.17 | -1.68% | |
| 1.21 | 1.24 | 1.18 | 1.19 | +2.59% | |
| 1.17 | 1.20 | 1.15 | 1.16 | -2.52% | |
| 1.26 | 1.27 | 1.17 | 1.19 | -5.56% | |
| 1.22 | 1.31 | 1.20 | 1.26 | +4.13% | |
| 1.21 | 1.29 | 1.20 | 1.21 | +0.83% | |
| 1.20 | 1.22 | 1.17 | 1.20 | +0.84% | |
| 1.22 | 1.22 | 1.18 | 1.19 | -3.25% | |
| 1.27 | 1.29 | 1.21 | 1.23 | -1.60% | |
| 1.25 | 1.29 | 1.24 | 1.25 | -0.79% | |
| 1.36 | 1.40 | 1.24 | 1.26 | -7.35% | |
| 1.30 | 1.44 | 1.28 | 1.36 | +19.30% | |
| 1.14 | 1.15 | 1.12 | 1.14 | +0.88% | |
| 1.12 | 1.21 | 1.12 | 1.13 | +0.89% | |
| 1.14 | 1.14 | 1.11 | 1.12 | +0.90% | |
| 1.12 | 1.14 | 1.10 | 1.11 | -1.77% | |
| 1.14 | 1.15 | 1.11 | 1.13 | -0.88% | |
| 1.13 | 1.16 | 1.13 | 1.14 | +0.88% | |
| 1.13 | 1.15 | 1.13 | 1.13 | +0.89% | |
| 1.18 | 1.18 | 1.12 | 1.12 | -4.27% | |
| 1.20 | 1.21 | 1.17 | 1.17 | -1.68% | |
| 1.21 | 1.22 | 1.19 | 1.19 | -1.65% | |
| 1.20 | 1.22 | 1.19 | 1.21 | -0.82% | |
| 1.22 | 1.23 | 1.20 | 1.22 | 0.00% | |
| 1.20 | 1.24 | 1.20 | 1.22 | +1.67% | |
| 1.22 | 1.22 | 1.18 | 1.20 | -1.64% | |
| 1.20 | 1.23 | 1.20 | 1.22 | +1.67% | |
| 1.21 | 1.22 | 1.18 | 1.20 | -0.83% | |
| 1.22 | 1.23 | 1.18 | 1.21 | -0.82% | |
| 1.22 | 1.23 | 1.20 | 1.22 | -0.81% | |
| 1.23 | 1.26 | 1.20 | 1.23 | +1.23% | |
| 1.22 | 1.24 | 1.20 | 1.22 | -0.41% | |
| 1.22 | 1.25 | 1.21 | 1.22 | +0.83% | |
| 1.22 | 1.27 | 1.20 | 1.21 | -1.63% | |
| 1.20 | 1.24 | 1.19 | 1.23 | +2.50% | |
| 1.20 | 1.20 | 1.18 | 1.20 | +0.84% | |
| 1.21 | 1.24 | 1.19 | 1.19 | -3.25% | |
| 1.26 | 1.26 | 1.19 | 1.23 | -0.81% | |
| 1.26 | 1.30 | 1.21 | 1.24 | +4.20% | |
| 1.24 | 1.25 | 1.19 | 1.19 | -3.25% | |
| 1.24 | 1.25 | 1.21 | 1.23 | 0.00% | |
| 1.25 | 1.28 | 1.23 | 1.23 | -2.38% | |
| 1.27 | 1.28 | 1.24 | 1.26 | -0.79% | |
| 1.26 | 1.28 | 1.23 | 1.27 | +0.79% | |
| 1.25 | 1.28 | 1.21 | 1.26 | +2.44% | |
| 1.15 | 1.25 | 1.15 | 1.23 | +6.96% | |
| 1.19 | 1.22 | 1.13 | 1.15 | -1.71% | |
| 1.20 | 1.21 | 1.17 | 1.17 | -2.50% | |
| 1.20 | 1.22 | 1.18 | 1.20 | +0.84% | |
| 1.20 | 1.21 | 1.16 | 1.19 | -0.42% | |
| 1.18 | 1.28 | 1.15 | 1.20 | +1.27% | |
| 1.20 | 1.23 | 1.16 | 1.18 | -0.84% | |
| 1.14 | 1.23 | 1.08 | 1.19 | +2.59% | |
| 1.28 | 1.28 | 1.10 | 1.16 | -8.66% | |
| 1.38 | 1.41 | 1.25 | 1.27 | -7.97% | |
| 1.43 | 1.44 | 1.37 | 1.38 | -4.17% | |
| 1.57 | 1.57 | 1.41 | 1.44 | -8.86% | |
| 1.52 | 1.64 | 1.50 | 1.58 | +0.64% | |
| 1.68 | 1.69 | 1.52 | 1.57 | -7.65% | |
| 1.71 | 1.71 | 1.63 | 1.70 | 0.00% | |
| 2.17 | 2.34 | 1.67 | 1.70 | -22.02% | |
| 2.11 | 2.19 | 2.07 | 2.18 | +3.81% | |
| 2.12 | 2.16 | 2.05 | 2.10 | -0.94% | |
| 2.19 | 2.20 | 2.12 | 2.12 | -2.30% | |
| 2.14 | 2.23 | 2.13 | 2.17 | +0.46% | |
| 2.16 | 2.20 | 2.12 | 2.16 | -1.37% | |
| 2.17 | 2.21 | 2.15 | 2.19 | -0.45% | |
| 2.23 | 2.28 | 2.15 | 2.20 | -0.90% | |
| 2.21 | 2.27 | 2.21 | 2.22 | +0.45% | |
| 2.26 | 2.29 | 2.20 | 2.21 | -2.21% | |
| 2.26 | 2.33 | 2.25 | 2.26 | 0.00% | |
| 2.03 | 2.33 | 2.01 | 2.26 | +11.88% | |
| 2.12 | 2.13 | 2.02 | 2.02 | -3.81% | |
| 2.15 | 2.23 | 2.10 | 2.10 | -2.33% | |
| 2.16 | 2.23 | 2.15 | 2.15 | -2.71% | |
| 2.28 | 2.36 | 2.16 | 2.21 | -3.07% | |
| 2.51 | 2.51 | 2.15 | 2.28 | +8.06% | |
| 2.87 | 3.05 | 1.95 | 2.11 | -23.83% | |
| 2.94 | 2.98 | 2.75 | 2.77 | -4.81% | |
| 2.93 | 2.97 | 2.85 | 2.91 | +2.11% | |
| 2.72 | 2.85 | 2.70 | 2.85 | +5.56% | |
| 2.55 | 2.76 | 2.48 | 2.70 | +6.30% | |
| 2.62 | 2.64 | 2.51 | 2.54 | -1.17% | |
| 2.78 | 2.81 | 2.52 | 2.57 | -6.20% | |
| 2.84 | 2.87 | 2.73 | 2.74 | -2.84% | |
| 3.00 | 3.00 | 2.76 | 2.82 | -5.37% | |
| 2.79 | 3.07 | 2.78 | 2.98 | +6.43% | |
| 2.86 | 2.87 | 2.77 | 2.80 | -1.06% | |
| 2.81 | 2.87 | 2.76 | 2.83 | 0.00% | |
| 2.83 | 2.89 | 2.79 | 2.83 | 0.00% | |
| 2.92 | 2.92 | 2.75 | 2.83 | -2.41% | |
| 2.93 | 3.00 | 2.90 | 2.90 | -1.02% | |
| 2.86 | 3.08 | 2.81 | 2.93 | +2.45% | |
| 2.80 | 2.95 | 2.76 | 2.86 | +3.62% | |
| 2.71 | 2.85 | 2.69 | 2.76 | +2.60% | |
| 2.63 | 2.71 | 2.56 | 2.69 | +2.28% | |
| 2.59 | 2.65 | 2.55 | 2.63 | +1.54% | |
| 2.52 | 2.62 | 2.50 | 2.59 | +0.39% | |
| 2.77 | 2.79 | 2.57 | 2.58 | -7.53% | |
| 2.71 | 2.89 | 2.69 | 2.79 | +1.09% | |
| 2.44 | 2.76 | 2.37 | 2.76 | +13.11% | |
| 2.56 | 2.56 | 2.43 | 2.44 | -3.94% | |
| 2.51 | 2.56 | 2.48 | 2.54 | -0.39% | |
| 2.62 | 2.67 | 2.54 | 2.55 | -0.39% | |
| 2.52 | 2.58 | 2.49 | 2.56 | +1.99% | |
| 2.54 | 2.62 | 2.50 | 2.51 | -0.79% | |
| 2.47 | 2.57 | 2.44 | 2.53 | +4.55% | |
| 2.51 | 2.59 | 2.41 | 2.42 | -3.20% | |
| 2.50 | 2.61 | 2.46 | 2.50 | +0.81% | |
| 2.54 | 2.63 | 2.48 | 2.48 | -1.20% | |
| 2.50 | 2.58 | 2.50 | 2.51 | -0.79% | |
| 2.65 | 2.66 | 2.47 | 2.53 | -5.24% | |
| 2.68 | 2.73 | 2.67 | 2.67 | 0.00% | |
| 2.74 | 2.75 | 2.67 | 2.67 | -2.55% | |
| 2.82 | 2.82 | 2.74 | 2.74 | -2.14% | |
| 2.86 | 2.91 | 2.79 | 2.80 | -2.10% | |
| 2.84 | 2.93 | 2.84 | 2.86 | +2.14% | |
| 2.82 | 2.82 | 2.74 | 2.80 | -1.41% | |
| 2.73 | 2.86 | 2.71 | 2.84 | +3.27% | |
| 2.71 | 2.78 | 2.65 | 2.75 | +2.61% | |
| 2.64 | 2.71 | 2.62 | 2.68 | +1.52% | |
| 2.78 | 2.80 | 2.63 | 2.64 | -5.04% | |
| 2.84 | 2.88 | 2.76 | 2.78 | 0.00% | |
| 2.67 | 2.86 | 2.67 | 2.78 | +4.12% | |
| 2.80 | 2.80 | 2.63 | 2.67 | -3.96% | |
| 2.72 | 2.80 | 2.67 | 2.78 | +2.21% | |
| 2.70 | 2.75 | 2.61 | 2.72 | +1.87% | |
| 2.59 | 2.69 | 2.48 | 2.67 | +2.30% | |
| 2.44 | 2.61 | 2.44 | 2.61 | +7.41% | |
| 2.41 | 2.45 | 2.38 | 2.43 | -0.82% | |
| 2.35 | 2.48 | 2.34 | 2.45 | +4.70% | |
| 2.29 | 2.36 | 2.21 | 2.34 | +4.46% | |
| 2.39 | 2.43 | 2.24 | 2.24 | -3.86% | |
| 2.30 | 2.44 | 2.28 | 2.33 | -1.69% | |
| 2.39 | 2.48 | 2.34 | 2.37 | -1.66% | |
| 2.39 | 2.46 | 2.37 | 2.41 | +1.69% | |
| 2.29 | 2.47 | 2.29 | 2.37 | +0.85% | |
| 2.37 | 2.41 | 2.33 | 2.35 | -0.84% | |
| 2.47 | 2.47 | 2.35 | 2.37 | -4.05% | |
| 2.45 | 2.48 | 2.38 | 2.47 | +0.41% | |
| 2.58 | 2.58 | 2.40 | 2.46 | -4.65% | |
| 2.58 | 2.70 | 2.57 | 2.58 | -0.39% | |
| 2.57 | 2.62 | 2.55 | 2.59 | +0.39% | |
| 2.58 | 2.60 | 2.51 | 2.58 | -0.39% | |
| 2.56 | 2.64 | 2.50 | 2.59 | 0.00% | |
| 2.43 | 2.60 | 2.40 | 2.59 | +5.71% | |
| 2.31 | 2.46 | 2.31 | 2.45 | +5.60% | |
| 2.27 | 2.36 | 2.22 | 2.32 | +0.87% | |
| 2.27 | 2.31 | 2.25 | 2.30 | +0.44% | |
| 2.26 | 2.30 | 2.22 | 2.29 | 0.00% | |
| 2.21 | 2.31 | 2.20 | 2.29 | +4.57% | |
| 2.13 | 2.21 | 2.11 | 2.19 | 0.00% | |
| 2.12 | 2.21 | 2.12 | 2.19 | +0.92% | |
| 2.22 | 2.27 | 2.15 | 2.17 | -1.81% | |
| 2.22 | 2.25 | 2.17 | 2.21 | -0.45% | |
| 2.22 | 2.26 | 2.19 | 2.22 | -0.45% | |
| 2.23 | 2.26 | 2.15 | 2.23 | -0.45% | |
| 2.32 | 2.33 | 2.20 | 2.24 | -2.61% | |
| 2.38 | 2.39 | 2.28 | 2.30 | -4.17% | |
| 2.33 | 2.41 | 2.32 | 2.40 | +3.00% | |
| 2.35 | 2.41 | 2.32 | 2.33 | -0.85% | |
| 2.39 | 2.40 | 2.30 | 2.35 | -1.67% | |
| 2.38 | 2.44 | 2.38 | 2.39 | +0.42% | |
| 2.37 | 2.41 | 2.32 | 2.38 | +0.42% | |
| 2.37 | 2.43 | 2.32 | 2.37 | +0.42% | |
| 2.40 | 2.40 | 2.35 | 2.36 | 0.00% | |
| 2.40 | 2.40 | 2.28 | 2.36 | -2.48% | |
| 2.31 | 2.43 | 2.31 | 2.42 | +5.22% | |
| 2.25 | 2.49 | 2.25 | 2.30 | +0.44% | |
| 2.26 | 2.32 | 2.19 | 2.29 | +7.01% | |
| 2.21 | 2.29 | 2.10 | 2.14 | -4.04% | |
| 2.15 | 2.27 | 2.14 | 2.23 | +1.83% | |
| 2.24 | 2.25 | 2.18 | 2.19 | -2.67% | |
| 2.23 | 2.30 | 2.22 | 2.25 | +0.90% | |
| 2.36 | 2.37 | 2.22 | 2.23 | -5.91% | |
| 2.45 | 2.45 | 2.35 | 2.37 | -3.27% | |
| 2.43 | 2.47 | 2.37 | 2.45 | +0.41% | |
| 2.44 | 2.46 | 2.42 | 2.44 | -0.41% | |
| 2.34 | 2.46 | 2.32 | 2.45 | +3.81% | |
| 2.38 | 2.41 | 2.32 | 2.36 | -0.84% | |
| 2.40 | 2.40 | 2.31 | 2.38 | -1.24% | |
| 2.40 | 2.42 | 2.34 | 2.41 | +0.42% | |
| 2.50 | 2.51 | 2.39 | 2.40 | -4.38% | |
| 2.45 | 2.52 | 2.41 | 2.51 | +2.45% | |
| 2.51 | 2.52 | 2.45 | 2.45 | -2.39% | |
| 2.53 | 2.55 | 2.48 | 2.51 | -1.57% | |
| 2.57 | 2.57 | 2.52 | 2.55 | -0.78% | |
| 2.59 | 2.60 | 2.51 | 2.57 | -1.15% | |
| 2.51 | 2.66 | 2.49 | 2.60 | +3.59% | |
| 2.44 | 2.52 | 2.42 | 2.51 | +3.29% | |
| 2.38 | 2.47 | 2.38 | 2.43 | +3.40% | |
| 2.32 | 2.37 | 2.30 | 2.35 | +0.86% | |
| 2.27 | 2.33 | 2.27 | 2.33 | +2.64% | |
| 2.29 | 2.30 | 2.27 | 2.27 | -1.30% | |
| 2.31 | 2.32 | 2.27 | 2.30 | -0.86% | |
| 2.33 | 2.37 | 2.27 | 2.32 | -0.85% | |
| 2.32 | 2.36 | 2.31 | 2.34 | +0.43% | |
| 2.36 | 2.42 | 2.31 | 2.33 | -1.69% | |
| 2.32 | 2.37 | 2.29 | 2.37 | +2.16% | |
| 2.35 | 2.42 | 2.28 | 2.32 | +1.31% | |
| 2.33 | 2.34 | 2.28 | 2.29 | -0.87% | |
| 2.29 | 2.38 | 2.29 | 2.31 | +1.76% | |
| 2.29 | 2.31 | 2.26 | 2.27 | -0.87% | |
| 2.33 | 2.35 | 2.29 | 2.29 | -1.29% | |
| 2.36 | 2.36 | 2.30 | 2.32 | -1.28% | |
| 2.33 | 2.36 | 2.31 | 2.35 | +0.86% | |
| 2.34 | 2.39 | 2.31 | 2.33 | 0.00% | |
| 2.31 | 2.35 | 2.26 | 2.33 | +0.87% | |
| 2.29 | 2.36 | 2.27 | 2.31 | +2.21% | |
| 2.29 | 2.31 | 2.25 | 2.26 | -0.88% | |
| 2.27 | 2.33 | 2.24 | 2.28 | 0.00% | |
| 2.21 | 2.29 | 2.18 | 2.28 | +3.64% | |
| 2.28 | 2.29 | 2.20 | 2.20 | -3.08% | |
| 2.33 | 2.38 | 2.26 | 2.27 | -5.42% | |
| 2.35 | 2.42 | 2.33 | 2.40 | +3.00% | |
| 2.35 | 2.38 | 2.28 | 2.33 | -0.43% | |
| 2.37 | 2.37 | 2.30 | 2.34 | -1.68% | |
| 2.34 | 2.40 | 2.33 | 2.38 | +3.03% | |
| 2.22 | 2.33 | 2.21 | 2.31 | +2.21% | |
| 2.40 | 2.42 | 2.23 | 2.26 | -5.04% | |
| 2.47 | 2.47 | 2.33 | 2.38 | -3.64% | |
| 2.40 | 2.49 | 2.37 | 2.47 | +1.65% | |
| 2.41 | 2.57 | 2.41 | 2.43 | +0.83% | |
| 2.39 | 2.48 | 2.33 | 2.41 | -1.23% | |
| 2.66 | 2.72 | 2.43 | 2.44 | -8.27% | |
| 2.63 | 2.75 | 2.61 | 2.66 | +1.53% | |
| 2.50 | 2.66 | 2.50 | 2.62 | +4.80% | |
| 2.45 | 2.57 | 2.45 | 2.50 | +1.63% | |
| 2.38 | 2.46 | 2.35 | 2.46 | +2.93% | |
| 2.43 | 2.47 | 2.38 | 2.39 | -1.65% | |
| 2.35 | 2.48 | 2.35 | 2.43 | +3.40% | |
| 2.35 | 2.47 | 2.33 | 2.35 | -1.26% | |
| 2.44 | 2.47 | 2.32 | 2.38 | -2.06% | |
| 2.35 | 2.48 | 2.33 | 2.43 | +2.97% | |
| 2.33 | 2.44 | 2.31 | 2.36 | +1.29% | |
| 2.37 | 2.40 | 2.30 | 2.33 | -2.10% | |
| 2.28 | 2.42 | 2.27 | 2.38 | +3.93% | |
| 2.22 | 2.30 | 2.21 | 2.29 | +3.62% | |
| 2.20 | 2.25 | 2.19 | 2.21 | +0.45% | |
| 2.24 | 2.28 | 2.16 | 2.20 | -2.22% | |
| 2.30 | 2.32 | 2.24 | 2.25 | -5.06% | |
| 2.31 | 2.50 | 2.30 | 2.37 | +3.49% | |
| 2.22 | 2.32 | 2.22 | 2.29 | +3.62% | |
| 2.31 | 2.32 | 2.21 | 2.21 | -5.96% | |
| 2.50 | 2.52 | 2.34 | 2.35 | -5.62% | |
| 2.40 | 2.49 | 2.36 | 2.49 | +5.51% | |
| 2.24 | 2.39 | 2.24 | 2.36 | +3.06% | |
| 2.35 | 2.41 | 2.24 | 2.29 | +1.78% | |
| 2.38 | 2.41 | 2.25 | 2.25 | -4.66% | |
| 2.35 | 2.42 | 2.32 | 2.36 | — |
Prices are adjusted for stock splits. See adjusted closing price for how dividends and splits affect history, and the SPRO chart for longer ranges.