Hyperion DeFi (HYPD) vs Mereo BioPharma Group (MREO)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 9, 2026.
Summary
Hyperion DeFi (HYPD) has outperformed Mereo BioPharma Group (MREO) over the past year, losing 62.9% versus a loss of 80.9%. Over five years, MREO leads with a -82.8% price change compared with -99.2% for HYPD. Mereo BioPharma Group is the larger company by market cap ($55.3 million vs $51.8 million), about 1.1 times the size.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | HYPD | MREO |
|---|---|---|
| Share price | $3.41 | $0.3465 |
| Market cap | $51.84M | $55.33M |
| 1-day change | +1.34% | -7.64% |
| YTD return | -5.48% | -10.02% |
| 1-year return | -62.86% | -80.86% |
| 5-year return | -99.21% | -82.79% |
| EPS (TTM) | $-6.46 | $-0.20 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| 52-week high | $9.50 | $2.37 |
| 52-week low | $2.34 | $0.20 |
| Distance from 52-week high | -64.11% | -85.38% |
| Analyst consensus | none | none |
| Avg. price target upside | +188.27% | +465.66% |
| Average volume | 447.98K | 4.04M |
| Shares outstanding | 15.20M | 159.69M |
| Employees | 9 | 39 |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- HYPD has outperformed MREO by 18.0 percentage points over the past year.
About Hyperion DeFi
HYPD stock →Hyperion DeFi, Inc., a DeFi company, engages in building on Hyperliquid. It operates through two segments: Ophthalmic Technology and Digital Assets.
Health Care · Biotechnology: Pharmaceutical Preparations · 9 employees
About Mereo BioPharma Group
MREO stock →Mereo BioPharma Group plc, a biopharmaceutical company, develops and commercializes therapeutics for the treatment of rare diseases in the United Kingdom and the United States. The company develops Setrusumab, an antibody for the treatment of osteogenesis imperfecta; Alvelestat, an oral small molecule that is in Phase II clinical trial to treat Alpha-1 anti-trypsin deficiency associated lung disease; and Vantictumab, an anti-FZD monoclonal antibody for the treatment of autosomal dominant osteopetrosis type 2.
Health Care · Biotechnology: Pharmaceutical Preparations · 39 employees
HYPD vs MREO FAQ
Which is bigger, Hyperion DeFi or Mereo BioPharma Group?
Mereo BioPharma Group (MREO) is larger, with a market capitalization of $55.33M compared with $51.84M for Hyperion DeFi (HYPD).
Which stock has performed better over the past year, HYPD or MREO?
HYPD returned -62.86% over the past 12 months, compared with -80.86% for MREO (price return, excluding dividends). Past performance does not predict future results.
Are Hyperion DeFi and Mereo BioPharma Group in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.