OneMedNet (ONMD) vs OptimizeRx (OPRX)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 9, 2026.
Summary
OptimizeRx (OPRX) has outperformed OneMedNet (ONMD) over the past year, losing 54.1% versus a loss of 79.0%. Over five years, OPRX leads with a -90.1% price change compared with -95.2% for ONMD. OptimizeRx is the larger company by market cap ($157.8 million vs $28.1 million), about 5.6 times the size.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | ONMD | OPRX |
|---|---|---|
| Share price | $4.82 | $8.38 |
| Market cap | $28.08M | $157.85M |
| 1-day change | -1.83% | -1.99% |
| YTD return | -56.18% | -31.65% |
| 1-year return | -79.04% | -54.06% |
| 5-year return | -95.21% | -90.10% |
| P/E ratio (TTM) | — | 34.92 |
| Forward P/E | — | 8.03 |
| EPS (TTM) | $-1.60 | $0.24 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| 52-week high | $42.20 | $22.25 |
| 52-week low | $4.73 | $4.54 |
| Distance from 52-week high | -88.58% | -62.34% |
| Analyst consensus | — | strong_buy |
| Avg. price target upside | — | +50.36% |
| Average volume | 114.91K | 203.38K |
| Shares outstanding | 5.82M | 18.84M |
| Employees | 22 | 132 |
| Sector | Healthcare | Healthcare |
| Industry | Health Information Services | Health Information Services |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- OptimizeRx is about 5.6 times larger than OneMedNet by market value ($157.85M vs $28.08M).
- OPRX has outperformed ONMD by 25.0 percentage points over the past year.
About OneMedNet
ONMD stock →OneMedNet Corporation, a healthcare software company, provides digital medical image management, exchange, and sharing solutions in the Americas, Europe, and the Middle East. It offers iRWD, which provides regulatory grade imaging and clinical data in the pharmaceutical, device manufacturing, contract research organizations, and artificial intelligence markets markets.
Healthcare · Health Information Services · 22 employees
About OptimizeRx
OPRX stock →OptimizeRx Corporation operates as a digital healthcare technology company. It offers Dynamic Audience Activation Platform, which generates dynamic audiences with predictive analytics through machine learning methods; Micro-Neighborhood Targeting, which creates consumer audiences using a privacy-first process; Profiler, which provides insights into its customers' target consumers; banner messages, including brand messaging, therapeutic support messaging, affordability messaging, limited distribution drug information, and patient support program messaging through healthcare professionals; and media execution solutions, which deliver messages through consumer omnichannel network, including through programmatic display, programmatic connected television/over-the-top, programmatic social media, addressable television, digital out-of-home, programmatic audio, and email/direct mail.
Healthcare · Health Information Services · 132 employees
ONMD vs OPRX FAQ
Which is bigger, OneMedNet or OptimizeRx?
OptimizeRx (OPRX) is larger, with a market capitalization of $157.85M compared with $28.08M for OneMedNet (ONMD).
Which stock has performed better over the past year, ONMD or OPRX?
OPRX returned -54.06% over the past 12 months, compared with -79.04% for ONMD (price return, excluding dividends). Past performance does not predict future results.
Are OneMedNet and OptimizeRx in the same industry?
Yes. Both are classified in the Health Information Services industry within the Healthcare sector.