Karyopharm Therapeutics (KPTI) vs Lipocine (LPCN)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 10, 2026.
Summary
Lipocine (LPCN) has outperformed Karyopharm Therapeutics (KPTI) over the past year, losing 45.4% versus a loss of 89.6%. Over five years, LPCN leads with a -91.0% price change compared with -99.3% for KPTI. Lipocine is the larger company by market cap ($14.2 million vs $13.7 million), about 1.0 times the size.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | KPTI | LPCN |
|---|---|---|
| Share price | $0.605 | $1.72 |
| Market cap | $13.72M | $14.18M |
| 1-day change | +0.83% | -10.88% |
| YTD return | -91.78% | -78.58% |
| 1-year return | -89.60% | -45.40% |
| 5-year return | -99.28% | -91.05% |
| EPS (TTM) | $-14.45 | $-1.85 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| 52-week high | $10.99 | $12.37 |
| 52-week low | $0.5652 | $1.72 |
| Distance from 52-week high | -94.49% | -86.10% |
| Analyst consensus | none | none |
| Avg. price target upside | +1098.35% | +190.70% |
| Average volume | 1.71M | 1.75M |
| Shares outstanding | 22.68M | 8.24M |
| Employees | 228 | 14 |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- LPCN has outperformed KPTI by 44.2 percentage points over the past year.
About Karyopharm Therapeutics
KPTI stock →Karyopharm Therapeutics Inc., a commercial-stage pharmaceutical company, discovers, develops, and commercializes drugs directed against nuclear export for the treatment of cancer and other diseases in the United States. The company discovers, develops, and commercializes novel and small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1).
Health Care · Biotechnology: Pharmaceutical Preparations · 228 employees
About Lipocine
LPCN stock →Lipocine Inc., a clinical-stage biopharmaceutical company, engages in the research and development for the delivery of drugs using its proprietary delivery technology. The company offers TLANDO, an oral testosterone replacement therapy (TRT) comprising testosterone undecanoate.
Health Care · Biotechnology: Pharmaceutical Preparations · 14 employees
KPTI vs LPCN FAQ
Which is bigger, Karyopharm Therapeutics or Lipocine?
Lipocine (LPCN) is larger, with a market capitalization of $14.18M compared with $13.72M for Karyopharm Therapeutics (KPTI).
Which stock has performed better over the past year, KPTI or LPCN?
LPCN returned -45.40% over the past 12 months, compared with -89.60% for KPTI (price return, excluding dividends). Past performance does not predict future results.
Are Karyopharm Therapeutics and Lipocine in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.