Mirum Pharmaceuticals (MIRM) vs Rhythm Pharmaceuticals (RYTM)
Head-to-head comparison of performance, valuation, growth, profitability and dividends. Prices delayed 15 minutes; data as of Oct 8, 2026.
Summary
Mirum Pharmaceuticals (MIRM) has outperformed Rhythm Pharmaceuticals (RYTM) over the past year, gaining 9.4% versus a loss of 11.4%. Over five years, RYTM leads with a +682.1% price change compared with +371.0% for MIRM. Rhythm Pharmaceuticals is the larger company by market cap ($6.06 billion vs $5.14 billion), about 1.2 times the size, while Mirum Pharmaceuticals is growing revenue faster (+54.7% vs +45.8%).
Mirum Pharmaceuticals converts more of its revenue into profit, with a net margin of -4.5% versus -103.6%.
Summary generated from market data by MetaCap's automated system. Methodology
Relative performance
Percent change in share price from the first common trading day shown; excludes dividends.
Head-to-head
| Metric | MIRM | RYTM |
|---|---|---|
| Share price | $79.23 | $87.98 |
| Market cap | $5.14B | $6.06B |
| 1-day change | -1.75% | -0.53% |
| YTD return | +2.09% | -17.37% |
| 1-year return | +9.36% | -11.40% |
| 5-year return | +371.03% | +682.05% |
| EPS (TTM) | $-14.10 | $-3.12 |
| Dividend yield | 0.00% | 0.00% |
| Annual dividend | $0.00 | $0.00 |
| Revenue (latest FY) | $521.31M | $189.76M |
| Revenue growth (YoY) | +54.74% | +45.83% |
| Net income (latest FY) | $-23.36M | $-196.54M |
| Gross margin | — | 89.73% |
| Operating margin | -4.25% | -101.19% |
| Net margin | -4.48% | -103.57% |
| 52-week high | $130.00 | $122.20 |
| 52-week low | $63.23 | $74.50 |
| Distance from 52-week high | -39.05% | -28.00% |
| Analyst consensus | strong_buy | none |
| Avg. price target upside | +84.01% | +57.52% |
| Average volume | 698.74K | 649.06K |
| Shares outstanding | 64.93M | 68.85M |
| Employees | 433 | 414 |
| Sector | Health Care | Health Care |
| Industry | Biotechnology: Pharmaceutical Preparations | Biotechnology: Pharmaceutical Preparations |
Highlighted cells mark the higher value for growth, returns, margins and yield, and the lower value for P/E ratios. Highlighting is a mechanical comparison, not a recommendation.
Key differences
- MIRM has outperformed RYTM by 20.8 percentage points over the past year.
- Mirum Pharmaceuticals is more profitable, keeping -4.5 cents of every revenue dollar as net income versus -103.6 cents for Rhythm Pharmaceuticals.
- Mirum Pharmaceuticals grew revenue faster in its latest fiscal year (+54.74% vs +45.83%).
About Mirum Pharmaceuticals
MIRM stock →Mirum Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the development and commercialization of novel therapies for debilitating rare and orphan diseases. Its lead product candidate is LIVMARLI (maralixibat), an orally administered and minimally absorbed ileal bile acid transporter (IBAT) inhibitor that is approved for the treatment of cholestatic pruritus in patients with Alagille syndrome in the United States and internationally.
Health Care · Biotechnology: Pharmaceutical Preparations · 433 employees
About Rhythm Pharmaceuticals
RYTM stock →Rhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the rare neuroendocrine diseases in the United States and internationally. The company's lead product candidate is IMCIVREE (setmelanotide), a rare melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, Bardet-Biedl and Alström syndrome, Prader-Willi syndrome, and hypothalamic obesity.
Health Care · Biotechnology: Pharmaceutical Preparations · 414 employees
MIRM vs RYTM FAQ
Which is bigger, Mirum Pharmaceuticals or Rhythm Pharmaceuticals?
Rhythm Pharmaceuticals (RYTM) is larger, with a market capitalization of $6.06B compared with $5.14B for Mirum Pharmaceuticals (MIRM).
Which stock has performed better over the past year, MIRM or RYTM?
MIRM returned +9.36% over the past 12 months, compared with -11.40% for RYTM (price return, excluding dividends). Past performance does not predict future results.
Are Mirum Pharmaceuticals and Rhythm Pharmaceuticals in the same industry?
Yes. Both are classified in the Biotechnology: Pharmaceutical Preparations industry within the Health Care sector.