Ionis Pharmaceuticals Stock Price History
NASDAQ: IONSHealth CareBiotechnology: Pharmaceutical PreparationsUSD
45.28+1.98 (+4.57%)
At close: Oct 9, 4:00 PM ET · Delayed 15 min
IONS price history at a glance
The price history for Ionis Pharmaceuticals (IONS) on this page begins on May 13, 1991, when the stock closed at $10.00; it most recently closed at $45.28 on October 5, 2026. The highest price in this record is $86.74, reached on February 2, 2026; the latest close is 47.8% below that peak. Across the 34 complete calendar years in the table, IONS finished higher in 18 and lower in 16. Its best year was 2013 (+257.9%) and its worst was 2002 (-67.5%).
Over roughly 35 years the share price changed +352.8%, a 4.4% compound annual price return (excluding dividends). In the last 12 months alone, IONS has lost 35.6%. Prices are split-adjusted closing prices; daily open, high, low, close and volume for the past year are listed below.
Summary generated from market data by MetaCap's automated system. Methodology
Key price levels
- High since 1991
- $86.74
- Date of high
- Feb 2, 2026
- Low since 1991
- $2.50
- Date of low
- Mar 17, 2003
- 52-week high
- $86.74
- 52-week low
- $42.63
- Last close
- $45.28
IONS returns
1 week
+4.00%
1 month
-19.17%
3 months
-22.27%
6 months
-39.76%
Year to date
-42.76%
1 year
-35.56%
3 years
-5.63%
5 years
+29.00%
IONS price return, excluding dividends.
IONS annual returns
| Year | Year-end close | Return |
|---|---|---|
| 2026 | 45.28 | -43.17% |
| 2025 | 79.67 | +128.87% |
| 2024 | 34.81 | -31.19% |
| 2023 | 50.59 | +33.94% |
| 2022 | 37.77 | +24.12% |
| 2021 | 30.43 | -46.18% |
| 2020 | 56.54 | -6.45% |
| 2019 | 60.44 | +11.25% |
| 2018 | 54.33 | +8.01% |
| 2017 | 50.30 | +5.16% |
| 2016 | 47.83 | -22.77% |
| 2015 | 61.93 | +0.58% |
| 2014 | 61.57 | +57.95% |
| 2013 | 38.98 | +257.94% |
| 2012 | 10.89 | +51.04% |
| 2011 | 7.21 | -28.75% |
| 2010 | 10.12 | -8.91% |
| 2009 | 11.11 | -23.22% |
| 2008 | 14.47 | -3.66% |
| 2007 | 15.02 | +35.07% |
| 2006 | 11.12 | +112.21% |
| 2005 | 5.24 | -11.19% |
| 2004 | 5.90 | -13.36% |
| 2003 | 6.81 | +4.61% |
| 2002 | 6.51 | -67.45% |
| 2001 | 20.00 | +88.24% |
| 2000 | 10.63 | +70.00% |
| 1999 | 6.25 | -51.69% |
| 1998 | 12.94 | +2.48% |
| 1997 | 12.63 | -31.29% |
| 1996 | 18.38 | +40.00% |
| 1995 | 13.13 | +228.13% |
| 1994 | 4.00 | -40.74% |
| 1993 | 6.75 | -30.77% |
| 1992 | 9.75 | -27.78% |
| 1991* | 13.50 | +35.00% |
* Partial year: the record begins after the start of 1991; return measured from the first available close.
2026 return is year to date.
IONS daily prices (past year)
| Date | Open | High | Low | Close | Change |
|---|---|---|---|---|---|
| 43.21 | 45.72 | 43.12 | 45.28 | +4.57% | |
| 43.77 | 44.19 | 42.79 | 43.30 | -1.95% | |
| 43.75 | 44.26 | 43.53 | 44.16 | +0.36% | |
| 44.19 | 44.67 | 43.17 | 44.00 | +1.15% | |
| 43.75 | 43.96 | 42.63 | 43.50 | -0.09% | |
| 44.17 | 44.17 | 43.24 | 43.54 | -1.05% | |
| 44.63 | 45.95 | 43.96 | 44.00 | -1.46% | |
| 46.07 | 46.25 | 44.60 | 44.65 | -2.70% | |
| 45.53 | 46.46 | 45.39 | 45.89 | +0.70% | |
| 44.56 | 46.95 | 44.06 | 45.57 | +2.40% | |
| 44.25 | 45.28 | 43.62 | 44.50 | +1.57% | |
| 43.77 | 44.60 | 43.25 | 43.81 | -0.27% | |
| 46.23 | 46.41 | 43.01 | 43.93 | -3.98% | |
| 44.96 | 46.13 | 44.44 | 45.75 | +1.89% | |
| 44.95 | 45.25 | 44.20 | 44.90 | +1.04% | |
| 46.75 | 46.75 | 44.27 | 44.44 | -4.94% | |
| 46.68 | 47.42 | 45.75 | 46.75 | +4.26% | |
| 47.38 | 47.59 | 44.66 | 44.84 | -5.10% | |
| 51.37 | 51.37 | 46.72 | 47.25 | -8.15% | |
| 54.88 | 55.50 | 51.31 | 51.44 | -5.11% | |
| 55.94 | 56.16 | 54.16 | 54.21 | -2.59% | |
| 55.75 | 55.77 | 54.91 | 55.65 | -0.66% | |
| 56.38 | 56.96 | 55.70 | 56.02 | -1.22% | |
| 52.15 | 57.43 | 52.15 | 56.71 | -2.38% | |
| 58.36 | 58.96 | 57.78 | 58.09 | -0.07% | |
| 60.42 | 60.42 | 57.47 | 58.13 | -5.22% | |
| 60.25 | 61.77 | 59.78 | 61.33 | +2.42% | |
| 60.37 | 60.99 | 59.78 | 59.88 | -0.80% | |
| 61.07 | 61.07 | 59.70 | 60.36 | -1.13% | |
| 60.62 | 61.69 | 60.35 | 61.05 | -2.21% | |
| 63.48 | 63.48 | 62.34 | 62.43 | -1.47% | |
| 63.50 | 63.55 | 62.44 | 63.36 | -0.33% | |
| 62.53 | 64.19 | 62.19 | 63.57 | +2.47% | |
| 60.54 | 62.07 | 59.70 | 62.04 | +3.85% | |
| 59.64 | 60.92 | 59.06 | 59.74 | +1.67% | |
| 60.03 | 60.41 | 58.60 | 58.76 | -3.36% | |
| 60.11 | 61.36 | 59.61 | 60.80 | +1.98% | |
| 58.41 | 60.19 | 58.02 | 59.62 | +1.69% | |
| 57.11 | 58.74 | 56.41 | 58.63 | +2.43% | |
| 55.16 | 57.24 | 55.16 | 57.24 | +2.45% | |
| 56.50 | 56.81 | 55.56 | 55.87 | -1.17% | |
| 55.01 | 57.07 | 54.91 | 56.53 | +2.00% | |
| 56.79 | 57.16 | 55.37 | 55.42 | -2.67% | |
| 56.10 | 57.66 | 56.10 | 56.94 | +0.67% | |
| 54.73 | 56.60 | 54.40 | 56.56 | +3.80% | |
| 54.59 | 55.42 | 54.02 | 54.49 | +0.55% | |
| 55.17 | 55.36 | 53.58 | 54.19 | -1.60% | |
| 54.85 | 55.22 | 53.87 | 55.07 | +1.06% | |
| 52.66 | 54.54 | 52.17 | 54.49 | +5.25% | |
| 53.33 | 53.33 | 51.28 | 51.77 | -2.83% | |
| 53.92 | 54.04 | 52.65 | 53.28 | -1.41% | |
| 55.09 | 55.36 | 53.50 | 54.04 | -2.28% | |
| 56.56 | 56.56 | 54.00 | 55.30 | -1.18% | |
| 56.93 | 57.09 | 55.79 | 55.96 | -1.04% | |
| 56.32 | 57.36 | 56.19 | 56.55 | +1.22% | |
| 53.71 | 57.48 | 53.35 | 55.87 | +3.44% | |
| 51.16 | 54.06 | 50.01 | 54.01 | +1.16% | |
| 52.75 | 54.13 | 52.26 | 53.39 | +0.83% | |
| 54.47 | 54.80 | 52.82 | 52.95 | -2.65% | |
| 54.10 | 54.69 | 53.76 | 54.39 | -0.48% | |
| 53.95 | 55.98 | 53.38 | 54.65 | -0.15% | |
| 54.48 | 54.89 | 53.51 | 54.73 | -0.36% | |
| 55.80 | 56.46 | 54.53 | 54.93 | -3.21% | |
| 57.91 | 57.91 | 56.11 | 56.75 | -2.58% | |
| 64.27 | 64.44 | 58.20 | 58.25 | -9.37% | |
| 67.78 | 70.35 | 64.10 | 64.27 | -23.90% | |
| 85.56 | 86.74 | 83.92 | 84.46 | -2.17% | |
| 84.42 | 86.67 | 82.95 | 86.33 | +3.79% | |
| 82.11 | 84.01 | 81.19 | 83.18 | +1.69% | |
| 79.53 | 81.99 | 79.11 | 81.80 | +3.30% | |
| 79.13 | 79.48 | 77.95 | 79.19 | -0.13% | |
| 81.17 | 81.24 | 79.21 | 79.29 | -1.74% | |
| 81.00 | 82.53 | 79.95 | 80.69 | -0.60% | |
| 78.80 | 82.63 | 78.80 | 81.18 | +3.63% | |
| 76.69 | 79.55 | 76.25 | 78.34 | +2.38% | |
| 76.40 | 79.00 | 76.04 | 76.52 | +0.70% | |
| 75.89 | 77.31 | 75.77 | 75.99 | +0.13% | |
| 74.85 | 76.56 | 74.12 | 75.89 | +2.39% | |
| 75.00 | 75.66 | 73.50 | 74.12 | -0.26% | |
| 73.09 | 75.12 | 72.55 | 74.31 | +1.67% | |
| 73.93 | 73.96 | 72.30 | 73.09 | -1.18% | |
| 73.49 | 74.27 | 72.88 | 73.96 | +0.93% | |
| 73.82 | 74.35 | 72.57 | 73.28 | -0.73% | |
| 73.34 | 74.48 | 72.76 | 73.82 | +0.68% | |
| 74.43 | 75.85 | 72.83 | 73.32 | -1.69% | |
| 74.77 | 75.79 | 73.53 | 74.58 | +1.41% | |
| 74.33 | 74.43 | 73.14 | 73.54 | -1.26% | |
| 75.24 | 75.96 | 73.81 | 74.48 | -0.87% | |
| 74.01 | 75.88 | 73.82 | 75.13 | +1.77% | |
| 72.68 | 74.12 | 72.02 | 73.82 | +1.16% | |
| 74.85 | 75.23 | 72.56 | 72.97 | -3.20% | |
| 75.67 | 76.19 | 74.70 | 75.38 | -1.46% | |
| 77.54 | 78.10 | 76.39 | 76.50 | -1.07% | |
| 76.58 | 78.00 | 75.34 | 77.33 | +1.10% | |
| 76.24 | 77.40 | 76.23 | 76.49 | +0.55% | |
| 76.00 | 76.74 | 74.73 | 76.07 | +0.67% | |
| 75.71 | 76.80 | 75.00 | 75.56 | -0.29% | |
| 74.76 | 76.48 | 74.21 | 75.78 | +0.96% | |
| 74.67 | 75.69 | 73.97 | 75.06 | +1.65% | |
| 72.76 | 74.15 | 72.00 | 73.84 | +1.82% | |
| 74.58 | 74.79 | 71.93 | 72.52 | -2.30% | |
| 75.89 | 75.93 | 73.32 | 74.23 | -1.92% | |
| 79.00 | 79.19 | 75.31 | 75.68 | -2.47% | |
| 75.67 | 78.03 | 75.08 | 77.60 | +2.33% | |
| 76.03 | 77.13 | 75.38 | 75.83 | +0.60% | |
| 76.03 | 77.01 | 74.85 | 75.38 | -0.44% | |
| 76.45 | 77.40 | 75.24 | 75.71 | -0.41% | |
| 76.56 | 76.56 | 74.87 | 76.02 | -1.08% | |
| 75.62 | 77.42 | 75.29 | 76.85 | +2.13% | |
| 75.84 | 76.96 | 74.82 | 75.25 | -0.27% | |
| 75.28 | 76.00 | 74.47 | 75.45 | +0.23% | |
| 74.86 | 76.17 | 72.94 | 75.28 | +0.70% | |
| 74.91 | 77.76 | 73.81 | 74.76 | -0.09% | |
| 72.06 | 74.96 | 71.30 | 74.83 | +4.25% | |
| 72.71 | 73.10 | 71.18 | 71.78 | -0.62% | |
| 74.04 | 75.10 | 72.21 | 72.23 | -1.42% | |
| 74.09 | 74.51 | 72.33 | 73.27 | -1.11% | |
| 74.96 | 76.06 | 73.23 | 74.09 | -0.99% | |
| 75.22 | 75.44 | 74.00 | 74.83 | +0.07% | |
| 75.87 | 75.96 | 73.80 | 74.78 | -0.12% | |
| 75.50 | 75.62 | 74.58 | 74.87 | -1.11% | |
| 75.66 | 76.33 | 74.95 | 75.71 | +0.60% | |
| 76.42 | 76.53 | 73.91 | 75.26 | -2.03% | |
| 77.10 | 77.18 | 75.77 | 76.82 | +0.08% | |
| 74.88 | 77.38 | 74.88 | 76.76 | +2.41% | |
| 75.17 | 77.17 | 74.56 | 74.95 | -0.29% | |
| 77.02 | 77.15 | 74.53 | 75.17 | -1.65% | |
| 74.98 | 76.97 | 74.62 | 76.43 | +1.93% | |
| 76.07 | 76.48 | 74.30 | 74.98 | +1.48% | |
| 74.05 | 74.27 | 72.42 | 73.89 | -0.59% | |
| 74.54 | 75.48 | 73.56 | 74.33 | -0.62% | |
| 73.74 | 75.13 | 73.35 | 74.79 | -0.45% | |
| 75.70 | 76.48 | 74.79 | 75.13 | +0.05% | |
| 73.64 | 75.92 | 73.45 | 75.09 | +3.54% | |
| 73.12 | 73.21 | 71.48 | 72.52 | +0.51% | |
| 74.00 | 74.05 | 71.87 | 72.15 | -2.82% | |
| 72.25 | 75.63 | 70.50 | 74.24 | +2.12% | |
| 70.68 | 73.61 | 70.68 | 72.70 | +4.33% | |
| 70.27 | 70.64 | 68.90 | 69.68 | -1.57% | |
| 72.25 | 73.15 | 70.67 | 70.79 | -0.28% | |
| 71.51 | 72.59 | 70.50 | 70.99 | -0.46% | |
| 71.40 | 71.94 | 70.51 | 71.32 | -0.49% | |
| 71.84 | 72.30 | 70.92 | 71.67 | -0.91% | |
| 72.35 | 73.30 | 71.92 | 72.33 | -0.01% | |
| 71.58 | 72.88 | 71.29 | 72.34 | +1.62% | |
| 73.21 | 74.16 | 70.42 | 71.19 | -1.59% | |
| 74.30 | 74.30 | 72.01 | 72.34 | -3.28% | |
| 75.15 | 76.00 | 74.54 | 74.79 | -1.15% | |
| 75.36 | 77.03 | 74.51 | 75.66 | +0.40% | |
| 73.50 | 75.63 | 73.45 | 75.36 | +1.78% | |
| 73.97 | 75.16 | 73.15 | 74.04 | -1.49% | |
| 78.16 | 79.04 | 74.27 | 75.16 | -5.40% | |
| 79.16 | 80.07 | 77.67 | 79.45 | +1.00% | |
| 80.42 | 81.40 | 78.50 | 78.66 | -4.03% | |
| 79.27 | 82.75 | 79.27 | 81.96 | +1.00% | |
| 80.59 | 82.10 | 80.06 | 81.15 | +0.68% | |
| 80.32 | 82.44 | 78.92 | 80.60 | -0.41% | |
| 81.75 | 85.12 | 80.47 | 80.93 | -5.29% | |
| 84.66 | 85.47 | 83.45 | 85.45 | +1.00% | |
| 82.71 | 84.96 | 82.71 | 84.60 | +1.74% | |
| 82.85 | 83.63 | 81.64 | 83.15 | 0.00% | |
| 81.50 | 83.34 | 80.39 | 83.15 | +1.13% | |
| 81.26 | 83.06 | 80.98 | 82.22 | +1.06% | |
| 80.30 | 82.53 | 80.23 | 81.36 | +0.94% | |
| 81.18 | 82.56 | 79.78 | 80.60 | -1.44% | |
| 84.20 | 84.91 | 81.20 | 81.78 | -3.05% | |
| 84.19 | 84.96 | 82.00 | 84.35 | +0.07% | |
| 84.49 | 84.81 | 83.57 | 84.29 | -0.59% | |
| 86.13 | 86.49 | 84.61 | 84.79 | -1.98% | |
| 84.85 | 86.59 | 84.18 | 86.50 | +3.62% | |
| 84.51 | 86.74 | 82.89 | 83.48 | -1.78% | |
| 85.72 | 85.95 | 82.55 | 84.99 | +0.47% | |
| 83.00 | 85.45 | 83.00 | 84.59 | +1.83% | |
| 82.54 | 83.35 | 81.90 | 83.07 | +0.48% | |
| 83.48 | 83.70 | 82.21 | 82.67 | -1.44% | |
| 82.38 | 84.30 | 81.90 | 83.88 | +2.39% | |
| 81.92 | 82.63 | 81.63 | 81.92 | -0.27% | |
| 81.01 | 82.52 | 81.01 | 82.14 | +1.41% | |
| 79.49 | 81.28 | 79.24 | 81.00 | +0.88% | |
| 81.71 | 82.20 | 79.11 | 80.29 | -1.83% | |
| 79.62 | 82.19 | 78.89 | 81.79 | +2.96% | |
| 77.09 | 79.54 | 77.01 | 79.44 | +2.46% | |
| 75.03 | 77.99 | 74.20 | 77.53 | +1.57% | |
| 77.15 | 78.00 | 74.49 | 76.33 | -1.14% | |
| 79.25 | 79.75 | 77.15 | 77.21 | -2.10% | |
| 79.04 | 79.57 | 77.69 | 78.87 | -0.77% | |
| 82.24 | 82.57 | 78.61 | 79.48 | -2.67% | |
| 80.50 | 82.21 | 78.88 | 81.66 | +1.69% | |
| 82.17 | 83.23 | 79.30 | 80.30 | -1.52% | |
| 83.17 | 83.79 | 79.95 | 81.54 | -1.96% | |
| 82.50 | 86.15 | 82.40 | 83.17 | +2.06% | |
| 78.89 | 81.54 | 78.00 | 81.49 | +3.77% | |
| 79.18 | 79.42 | 76.08 | 78.53 | -1.43% | |
| 79.88 | 80.21 | 78.02 | 79.67 | +0.71% | |
| 78.78 | 79.84 | 78.63 | 79.11 | +0.18% | |
| 79.50 | 79.99 | 78.52 | 78.97 | -1.26% | |
| 79.73 | 80.04 | 78.74 | 79.98 | +0.06% | |
| 80.15 | 80.42 | 79.18 | 79.93 | -0.89% | |
| 80.33 | 81.02 | 80.33 | 80.65 | +0.40% | |
| 80.61 | 81.84 | 79.63 | 80.33 | -1.24% | |
| 79.26 | 82.09 | 79.09 | 81.34 | +2.22% | |
| 77.80 | 79.83 | 77.63 | 79.57 | +2.50% | |
| 77.39 | 78.16 | 76.70 | 77.63 | +0.71% | |
| 78.77 | 79.49 | 77.07 | 77.08 | -1.65% | |
| 79.41 | 79.56 | 77.16 | 78.37 | -1.74% | |
| 80.35 | 81.00 | 79.31 | 79.76 | -1.31% | |
| 79.19 | 80.92 | 78.51 | 80.82 | +2.12% | |
| 78.63 | 79.86 | 78.05 | 79.14 | +0.65% | |
| 79.38 | 79.71 | 77.79 | 78.63 | -0.29% | |
| 80.55 | 81.23 | 78.32 | 78.86 | -3.25% | |
| 82.12 | 82.86 | 81.18 | 81.51 | -0.21% | |
| 82.19 | 82.44 | 80.64 | 81.68 | -0.16% | |
| 81.90 | 83.61 | 81.45 | 81.81 | -0.04% | |
| 81.70 | 83.09 | 80.98 | 81.84 | +0.65% | |
| 82.38 | 82.69 | 80.00 | 81.31 | -0.83% | |
| 82.03 | 82.27 | 80.11 | 81.99 | -0.89% | |
| 82.59 | 82.95 | 81.67 | 82.73 | +0.04% | |
| 81.15 | 82.91 | 80.75 | 82.70 | +2.19% | |
| 78.52 | 81.20 | 78.33 | 80.93 | +3.07% | |
| 76.34 | 78.79 | 76.16 | 78.52 | +3.19% | |
| 73.00 | 76.31 | 73.00 | 76.09 | +4.06% | |
| 74.17 | 75.40 | 72.50 | 73.12 | -1.19% | |
| 74.55 | 75.00 | 71.83 | 74.00 | -0.67% | |
| 72.81 | 74.52 | 71.99 | 74.50 | +1.69% | |
| 70.70 | 74.42 | 70.70 | 73.26 | +2.39% | |
| 69.66 | 72.54 | 68.90 | 71.55 | +2.45% | |
| 72.56 | 73.05 | 68.22 | 69.84 | -3.89% | |
| 71.19 | 74.50 | 70.40 | 72.67 | +0.30% | |
| 69.32 | 72.79 | 68.55 | 72.45 | +4.18% | |
| 70.05 | 71.49 | 66.66 | 69.54 | -5.45% | |
| 73.58 | 75.00 | 72.36 | 73.55 | -0.74% | |
| 74.58 | 76.78 | 73.91 | 74.10 | -0.78% | |
| 72.14 | 75.08 | 71.48 | 74.68 | +2.47% | |
| 72.40 | 74.21 | 72.40 | 72.88 | -1.05% | |
| 74.77 | 75.25 | 71.95 | 73.65 | -0.87% | |
| 74.50 | 75.49 | 74.02 | 74.30 | +0.18% | |
| 71.91 | 74.70 | 71.66 | 74.17 | +3.19% | |
| 72.37 | 74.05 | 71.14 | 71.88 | -2.30% | |
| 72.99 | 74.04 | 72.50 | 73.57 | +0.79% | |
| 72.03 | 73.27 | 71.46 | 72.99 | +3.01% | |
| 72.39 | 72.44 | 70.22 | 70.86 | -0.90% | |
| 71.69 | 72.44 | 71.05 | 71.50 | 0.00% | |
| 71.23 | 71.98 | 70.60 | 71.50 | -0.20% | |
| 72.94 | 73.20 | 70.47 | 71.64 | -2.60% | |
| 73.55 | 73.69 | 72.30 | 73.55 | +0.63% | |
| 72.96 | 74.02 | 72.32 | 73.09 | +0.03% | |
| 73.12 | 74.42 | 72.07 | 73.07 | +0.94% | |
| 71.42 | 73.92 | 71.24 | 72.39 | +1.43% | |
| 70.59 | 72.15 | 70.08 | 71.37 | +1.10% | |
| 70.16 | 71.50 | 69.84 | 70.59 | +0.89% | |
| 70.00 | 70.49 | 69.40 | 69.97 | -0.43% | |
| 70.21 | 70.89 | 69.68 | 70.27 | — |
Prices are adjusted for stock splits. See adjusted closing price for how dividends and splits affect history, and the IONS chart for longer ranges.