Karyopharm Therapeutics Stock Price History
NASDAQ: KPTIHealth CareBiotechnology: Pharmaceutical PreparationsUSD
0.605+0.005 (+0.83%)
At close: Oct 9, 4:00 PM ET · Delayed 15 min
KPTI price history at a glance
The price history for Karyopharm Therapeutics (KPTI) on this page begins on November 4, 2013, when the stock closed at $243.60; it most recently closed at $0.605 on October 5, 2026. The highest price in this record is $735.08, reached on December 8, 2014; the latest close is 99.9% below that peak. Across the 12 complete calendar years in the table, KPTI finished higher in 4 and lower in 8. Its best year was 2019 (+81.1%) and its worst was 2023 (-74.6%).
Over roughly 13 years the share price changed -99.8%, a -37.1% compound annual price return (excluding dividends). In the last 12 months alone, KPTI has lost 89.0%. Prices are split-adjusted closing prices; daily open, high, low, close and volume for the past year are listed below.
Summary generated from market data by MetaCap's automated system. Methodology
Key price levels
- High since 2013
- $735.08
- Date of high
- Dec 8, 2014
- Low since 2013
- $0.5652
- Date of low
- Oct 5, 2026
- 52-week high
- $10.99
- 52-week low
- $0.565
- IPO year
- 2013
- Last close
- $0.605
KPTI returns
1 week
-24.56%
1 month
-64.20%
3 months
-94.15%
6 months
-92.44%
Year to date
-91.78%
1 year
-89.00%
3 years
-96.61%
5 years
-99.28%
KPTI price return, excluding dividends.
KPTI annual returns
| Year | Year-end close | Return |
|---|---|---|
| 2026 | 0.605 | -91.59% |
| 2025 | 7.19 | -38.55% |
| 2024 | 11.70 | -9.83% |
| 2023 | 12.98 | -74.56% |
| 2022 | 51.00 | -47.12% |
| 2021 | 96.45 | -58.46% |
| 2020 | 232.20 | -15.04% |
| 2019 | 273.30 | +81.11% |
| 2018 | 150.90 | +4.79% |
| 2017 | 144.00 | +2.13% |
| 2016 | 141.00 | -29.06% |
| 2015 | 198.75 | -65.12% |
| 2014 | 569.85 | +67.14% |
| 2013* | 340.95 | +39.96% |
* Partial year: the record begins after the start of 2013; return measured from the first available close.
2026 return is year to date.
KPTI daily prices (past year)
| Date | Open | High | Low | Close | Change |
|---|---|---|---|---|---|
| 0.602 | 0.6253 | 0.5652 | 0.605 | +0.83% | |
| 0.63 | 0.6438 | 0.60 | 0.60 | -6.98% | |
| 0.65 | 0.6896 | 0.6258 | 0.645 | -0.77% | |
| 0.691 | 0.715 | 0.635 | 0.65 | -3.13% | |
| 0.802 | 0.802 | 0.626 | 0.671 | -16.33% | |
| 0.857 | 0.894 | 0.747 | 0.802 | -7.50% | |
| 1.19 | 1.20 | 0.848 | 0.867 | -28.93% | |
| 1.26 | 1.27 | 1.18 | 1.22 | +1.24% | |
| 1.62 | 1.63 | 1.20 | 1.21 | -25.62% | |
| 1.59 | 1.66 | 1.54 | 1.62 | 0.00% | |
| 1.73 | 1.77 | 1.57 | 1.62 | -6.36% | |
| 1.73 | 1.77 | 1.71 | 1.73 | -1.14% | |
| 1.81 | 1.84 | 1.66 | 1.75 | -3.85% | |
| 1.87 | 1.92 | 1.78 | 1.82 | -2.15% | |
| 1.85 | 1.93 | 1.78 | 1.86 | -1.06% | |
| 1.77 | 1.89 | 1.67 | 1.88 | +5.03% | |
| 1.75 | 1.85 | 1.66 | 1.79 | +5.29% | |
| 1.54 | 1.72 | 1.54 | 1.70 | +10.39% | |
| 1.59 | 1.70 | 1.53 | 1.54 | -3.75% | |
| 1.55 | 1.62 | 1.55 | 1.60 | -0.62% | |
| 1.50 | 1.61 | 1.24 | 1.61 | -0.62% | |
| 1.68 | 1.68 | 1.60 | 1.62 | -4.14% | |
| 1.72 | 1.75 | 1.65 | 1.69 | -1.74% | |
| 1.77 | 1.79 | 1.70 | 1.72 | -3.91% | |
| 1.77 | 1.84 | 1.76 | 1.79 | +1.13% | |
| 1.79 | 1.81 | 1.72 | 1.77 | -1.12% | |
| 1.90 | 1.94 | 1.73 | 1.79 | -3.24% | |
| 2.02 | 2.07 | 1.84 | 1.85 | -10.19% | |
| 1.91 | 2.14 | 1.79 | 2.06 | +10.16% | |
| 1.98 | 1.99 | 1.86 | 1.87 | -3.61% | |
| 1.99 | 2.06 | 1.93 | 1.94 | -1.02% | |
| 1.92 | 1.99 | 1.86 | 1.96 | +2.08% | |
| 1.87 | 1.95 | 1.87 | 1.92 | +3.23% | |
| 1.95 | 1.96 | 1.83 | 1.86 | -5.10% | |
| 1.85 | 1.97 | 1.82 | 1.96 | +7.69% | |
| 2.00 | 2.00 | 1.82 | 1.82 | -9.00% | |
| 1.93 | 2.02 | 1.93 | 2.00 | +3.63% | |
| 1.88 | 1.96 | 1.82 | 1.93 | +6.63% | |
| 2.02 | 2.03 | 1.79 | 1.81 | -10.40% | |
| 1.97 | 2.06 | 1.97 | 2.02 | +1.51% | |
| 2.03 | 2.09 | 1.92 | 1.99 | -1.97% | |
| 2.10 | 2.15 | 2.00 | 2.03 | -3.33% | |
| 1.93 | 2.18 | 1.93 | 2.10 | +7.14% | |
| 2.14 | 2.18 | 1.92 | 1.96 | -7.55% | |
| 1.96 | 2.12 | 1.91 | 2.12 | +8.72% | |
| 1.88 | 2.01 | 1.88 | 1.95 | +2.09% | |
| 1.94 | 2.06 | 1.88 | 1.91 | -2.55% | |
| 2.00 | 2.11 | 1.94 | 1.96 | -0.51% | |
| 1.94 | 2.05 | 1.80 | 1.97 | +2.60% | |
| 2.19 | 2.43 | 1.80 | 1.92 | -72.61% | |
| 6.98 | 7.09 | 6.56 | 7.01 | +2.19% | |
| 7.04 | 7.47 | 6.73 | 6.86 | -3.24% | |
| 7.10 | 7.14 | 6.75 | 7.09 | 0.00% | |
| 7.45 | 7.84 | 7.02 | 7.09 | -4.32% | |
| 7.15 | 7.61 | 6.99 | 7.41 | +4.51% | |
| 7.14 | 7.19 | 6.75 | 7.09 | -1.25% | |
| 7.92 | 8.02 | 7.05 | 7.18 | -8.71% | |
| 7.49 | 8.27 | 7.46 | 7.87 | +5.29% | |
| 9.40 | 9.45 | 6.49 | 7.47 | -21.45% | |
| 9.35 | 9.59 | 9.31 | 9.51 | +1.39% | |
| 9.55 | 9.84 | 9.36 | 9.38 | -1.57% | |
| 9.85 | 9.86 | 9.38 | 9.53 | -4.80% | |
| 10.07 | 10.17 | 9.82 | 10.01 | -0.40% | |
| 10.19 | 10.30 | 9.71 | 10.05 | -2.80% | |
| 10.30 | 10.59 | 9.88 | 10.34 | +1.37% | |
| 10.76 | 10.76 | 10.09 | 10.20 | -4.40% | |
| 10.02 | 10.86 | 9.91 | 10.67 | +6.17% | |
| 9.58 | 10.05 | 9.29 | 10.05 | +4.47% | |
| 9.60 | 9.77 | 9.20 | 9.62 | +0.21% | |
| 9.70 | 9.96 | 9.45 | 9.60 | +0.52% | |
| 9.68 | 9.85 | 9.34 | 9.55 | -2.25% | |
| 10.11 | 10.48 | 9.71 | 9.77 | -3.12% | |
| 10.16 | 10.44 | 9.64 | 10.09 | -1.22% | |
| 9.45 | 10.25 | 9.43 | 10.21 | +7.93% | |
| 9.08 | 9.65 | 9.01 | 9.46 | +3.73% | |
| 9.63 | 10.09 | 9.02 | 9.12 | -5.49% | |
| 8.89 | 9.70 | 8.78 | 9.65 | +7.22% | |
| 9.10 | 9.23 | 8.85 | 9.00 | -0.22% | |
| 9.60 | 9.74 | 8.90 | 9.02 | -4.04% | |
| 9.20 | 9.83 | 9.06 | 9.40 | +3.30% | |
| 9.64 | 9.64 | 9.00 | 9.10 | -5.60% | |
| 9.65 | 9.80 | 9.37 | 9.64 | +1.47% | |
| 9.10 | 10.22 | 9.04 | 9.50 | +5.56% | |
| 9.11 | 9.24 | 8.96 | 9.00 | -1.21% | |
| 8.67 | 9.34 | 8.58 | 9.11 | +4.83% | |
| 8.68 | 9.00 | 8.43 | 8.69 | +2.24% | |
| 9.18 | 9.44 | 8.43 | 8.50 | -6.39% | |
| 9.04 | 9.23 | 8.85 | 9.08 | +0.11% | |
| 9.00 | 9.39 | 8.84 | 9.07 | +0.78% | |
| 9.08 | 9.09 | 8.48 | 9.00 | -2.49% | |
| 9.81 | 9.82 | 8.50 | 9.23 | -6.01% | |
| 9.28 | 9.88 | 8.99 | 9.82 | +7.91% | |
| 9.12 | 9.46 | 8.94 | 9.10 | -0.11% | |
| 8.98 | 9.25 | 8.72 | 9.11 | +1.45% | |
| 8.99 | 9.98 | 8.74 | 8.98 | +0.11% | |
| 8.30 | 9.06 | 8.22 | 8.97 | +9.93% | |
| 8.07 | 8.42 | 8.00 | 8.16 | +1.24% | |
| 7.82 | 8.25 | 7.72 | 8.06 | +1.00% | |
| 7.38 | 8.17 | 7.38 | 7.98 | +6.83% | |
| 7.14 | 7.50 | 6.85 | 7.47 | +4.62% | |
| 7.66 | 8.04 | 7.08 | 7.14 | -6.91% | |
| 8.80 | 9.09 | 7.50 | 7.67 | -13.82% | |
| 9.53 | 10.23 | 8.70 | 8.90 | +0.56% | |
| 8.99 | 9.03 | 8.57 | 8.85 | -0.73% | |
| 8.84 | 9.25 | 8.73 | 8.92 | +1.19% | |
| 8.64 | 9.27 | 8.45 | 8.81 | +1.97% | |
| 8.87 | 9.00 | 8.54 | 8.64 | -2.37% | |
| 8.96 | 9.00 | 8.68 | 8.85 | -1.88% | |
| 9.61 | 9.61 | 9.02 | 9.02 | -4.14% | |
| 9.31 | 9.52 | 9.22 | 9.41 | +1.18% | |
| 8.75 | 9.55 | 8.67 | 9.30 | +6.04% | |
| 8.35 | 8.83 | 8.25 | 8.77 | +5.54% | |
| 8.44 | 8.66 | 8.17 | 8.31 | -1.07% | |
| 8.59 | 8.59 | 8.11 | 8.40 | -2.33% | |
| 8.66 | 8.93 | 8.50 | 8.60 | -0.69% | |
| 8.99 | 9.23 | 8.57 | 8.66 | 0.00% | |
| 8.77 | 8.89 | 8.40 | 8.66 | -1.03% | |
| 9.61 | 9.61 | 8.72 | 8.75 | -8.38% | |
| 9.31 | 9.67 | 9.11 | 9.55 | +4.14% | |
| 8.94 | 9.60 | 8.61 | 9.17 | +2.57% | |
| 8.54 | 9.00 | 8.26 | 8.94 | +3.83% | |
| 8.89 | 8.89 | 8.47 | 8.61 | -0.58% | |
| 8.62 | 8.94 | 8.42 | 8.66 | +1.17% | |
| 8.60 | 8.81 | 8.40 | 8.56 | +1.30% | |
| 8.40 | 8.57 | 8.30 | 8.45 | +2.05% | |
| 7.96 | 8.87 | 7.87 | 8.28 | +3.50% | |
| 8.16 | 8.24 | 7.81 | 8.00 | -1.96% | |
| 7.22 | 8.25 | 7.19 | 8.16 | +12.55% | |
| 7.36 | 7.72 | 7.08 | 7.25 | +0.55% | |
| 6.22 | 7.26 | 5.96 | 7.21 | +14.08% | |
| 5.90 | 6.55 | 5.85 | 6.32 | +7.30% | |
| 5.61 | 6.10 | 5.49 | 5.89 | +1.20% | |
| 5.61 | 5.86 | 5.39 | 5.82 | +4.49% | |
| 5.31 | 5.75 | 5.31 | 5.57 | +5.09% | |
| 5.40 | 5.57 | 5.25 | 5.30 | -3.28% | |
| 5.51 | 5.77 | 5.40 | 5.48 | -1.62% | |
| 5.08 | 5.61 | 5.00 | 5.57 | +6.91% | |
| 5.36 | 5.71 | 5.10 | 5.21 | -4.23% | |
| 6.03 | 6.50 | 5.14 | 5.44 | -18.32% | |
| 7.34 | 7.58 | 6.57 | 6.66 | -12.71% | |
| 7.76 | 9.04 | 7.44 | 7.63 | -1.29% | |
| 8.33 | 8.62 | 7.73 | 7.73 | -7.98% | |
| 8.35 | 8.68 | 7.96 | 8.40 | +0.24% | |
| 8.58 | 8.60 | 7.97 | 8.38 | -1.99% | |
| 7.86 | 8.63 | 7.86 | 8.55 | +8.92% | |
| 7.91 | 8.26 | 7.29 | 7.85 | -0.63% | |
| 8.70 | 8.90 | 7.64 | 7.90 | -9.71% | |
| 8.20 | 8.85 | 7.96 | 8.75 | +6.32% | |
| 8.94 | 8.94 | 8.21 | 8.23 | -3.06% | |
| 8.78 | 8.96 | 8.25 | 8.49 | -3.19% | |
| 8.72 | 9.11 | 8.57 | 8.77 | -0.57% | |
| 9.13 | 9.17 | 8.68 | 8.82 | -3.61% | |
| 9.12 | 9.55 | 8.97 | 9.15 | +0.22% | |
| 9.57 | 9.59 | 9.03 | 9.13 | -4.80% | |
| 9.16 | 9.83 | 8.75 | 9.59 | +1.91% | |
| 9.30 | 9.56 | 9.02 | 9.41 | +0.64% | |
| 10.09 | 10.11 | 9.16 | 9.35 | -7.33% | |
| 10.21 | 10.38 | 9.95 | 10.09 | +0.20% | |
| 10.03 | 10.99 | 9.78 | 10.07 | +0.40% | |
| 9.61 | 10.38 | 9.45 | 10.03 | +3.72% | |
| 9.70 | 9.82 | 9.40 | 9.67 | 0.00% | |
| 9.20 | 9.80 | 9.01 | 9.67 | +4.54% | |
| 9.64 | 9.82 | 9.14 | 9.25 | -1.60% | |
| 8.63 | 9.94 | 8.42 | 9.40 | +9.56% | |
| 8.98 | 9.45 | 8.11 | 8.58 | -4.03% | |
| 6.72 | 9.94 | 6.72 | 8.94 | +21.30% | |
| 6.58 | 7.38 | 6.28 | 7.37 | +11.84% | |
| 6.28 | 6.70 | 6.20 | 6.59 | +4.44% | |
| 6.30 | 6.60 | 5.90 | 6.31 | +0.80% | |
| 6.22 | 6.66 | 6.00 | 6.26 | +2.79% | |
| 6.43 | 6.97 | 6.02 | 6.09 | -3.33% | |
| 6.56 | 6.70 | 6.06 | 6.30 | -3.82% | |
| 6.33 | 6.88 | 6.25 | 6.55 | +3.80% | |
| 6.52 | 6.68 | 6.22 | 6.31 | -3.22% | |
| 6.66 | 6.80 | 6.42 | 6.52 | -1.66% | |
| 6.95 | 7.08 | 6.61 | 6.63 | -4.19% | |
| 7.03 | 7.20 | 6.91 | 6.92 | -1.84% | |
| 6.70 | 7.14 | 6.51 | 7.05 | +6.02% | |
| 6.58 | 6.82 | 6.36 | 6.65 | +0.91% | |
| 6.70 | 7.09 | 6.54 | 6.59 | -0.75% | |
| 6.35 | 6.64 | 6.08 | 6.64 | +5.06% | |
| 5.96 | 6.49 | 5.88 | 6.32 | +6.22% | |
| 6.19 | 6.34 | 5.89 | 5.95 | -5.71% | |
| 6.80 | 6.85 | 6.25 | 6.31 | -5.26% | |
| 7.17 | 7.24 | 6.49 | 6.66 | -7.37% | |
| 7.90 | 8.07 | 7.15 | 7.19 | -9.10% | |
| 8.19 | 8.27 | 7.57 | 7.91 | -3.48% | |
| 8.64 | 8.64 | 7.05 | 8.20 | -5.59% | |
| 8.29 | 8.95 | 8.11 | 8.68 | +6.24% | |
| 7.91 | 8.42 | 7.72 | 8.17 | +3.81% | |
| 7.39 | 8.15 | 7.39 | 7.87 | +7.07% | |
| 7.40 | 7.50 | 7.30 | 7.35 | -0.68% | |
| 7.22 | 7.42 | 7.10 | 7.40 | +2.92% | |
| 7.44 | 7.44 | 7.01 | 7.19 | -2.31% | |
| 7.31 | 7.43 | 7.30 | 7.36 | +0.68% | |
| 7.38 | 7.52 | 7.16 | 7.31 | -0.41% | |
| 7.37 | 7.49 | 7.12 | 7.34 | -1.34% | |
| 7.50 | 7.50 | 7.16 | 7.44 | -0.40% | |
| 7.44 | 7.54 | 7.32 | 7.47 | +0.40% | |
| 7.27 | 7.55 | 7.14 | 7.44 | +2.34% | |
| 7.00 | 7.70 | 6.92 | 7.27 | +4.76% | |
| 6.44 | 7.09 | 6.44 | 6.94 | +8.95% | |
| 6.04 | 6.77 | 6.04 | 6.37 | +5.81% | |
| 6.36 | 6.77 | 5.99 | 6.02 | -4.90% | |
| 6.68 | 6.81 | 6.33 | 6.33 | -5.66% | |
| 6.96 | 7.00 | 6.59 | 6.71 | -3.45% | |
| 7.07 | 7.48 | 6.85 | 6.95 | -0.71% | |
| 6.52 | 7.05 | 6.35 | 7.00 | +8.02% | |
| 6.35 | 6.69 | 6.19 | 6.48 | +1.41% | |
| 5.89 | 6.52 | 5.89 | 6.39 | +8.49% | |
| 5.84 | 6.01 | 5.70 | 5.89 | +2.43% | |
| 5.95 | 5.95 | 5.74 | 5.75 | -2.71% | |
| 5.41 | 6.05 | 5.37 | 5.91 | +8.24% | |
| 5.36 | 5.52 | 5.30 | 5.46 | +1.87% | |
| 5.71 | 5.80 | 5.34 | 5.36 | -6.78% | |
| 5.60 | 6.15 | 5.48 | 5.75 | +2.31% | |
| 5.46 | 5.71 | 5.46 | 5.62 | +1.26% | |
| 5.49 | 5.66 | 5.37 | 5.55 | +1.83% | |
| 5.58 | 5.67 | 5.31 | 5.45 | -1.98% | |
| 5.88 | 5.93 | 5.56 | 5.56 | -5.76% | |
| 5.64 | 5.95 | 5.60 | 5.90 | +2.43% | |
| 6.09 | 6.10 | 5.70 | 5.76 | -3.68% | |
| 6.30 | 6.50 | 5.80 | 5.98 | -4.17% | |
| 5.73 | 6.43 | 5.73 | 6.24 | +7.77% | |
| 5.68 | 6.06 | 5.53 | 5.79 | +1.94% | |
| 5.40 | 5.85 | 5.40 | 5.68 | +3.27% | |
| 5.55 | 5.70 | 5.35 | 5.50 | -1.61% | |
| 5.42 | 5.65 | 5.41 | 5.59 | +2.38% | |
| 5.34 | 5.71 | 5.25 | 5.46 | +0.37% | |
| 5.17 | 5.45 | 5.14 | 5.44 | +5.43% | |
| 5.22 | 5.28 | 5.01 | 5.16 | -1.15% | |
| 5.43 | 5.45 | 5.09 | 5.22 | -2.61% | |
| 5.61 | 5.72 | 5.34 | 5.36 | -5.13% | |
| 6.00 | 6.00 | 5.41 | 5.65 | -6.92% | |
| 5.80 | 6.17 | 5.66 | 6.07 | +4.66% | |
| 5.97 | 6.10 | 5.75 | 5.80 | -2.68% | |
| 5.96 | 6.29 | 5.95 | 5.96 | -1.97% | |
| 6.36 | 6.40 | 6.03 | 6.08 | -3.95% | |
| 6.43 | 6.60 | 6.30 | 6.33 | -1.40% | |
| 6.34 | 6.50 | 6.09 | 6.42 | +1.26% | |
| 6.28 | 6.39 | 6.11 | 6.34 | +2.42% | |
| 6.20 | 6.40 | 6.14 | 6.19 | +0.81% | |
| 6.47 | 6.75 | 5.71 | 6.14 | -4.51% | |
| 6.45 | 6.60 | 6.18 | 6.43 | -0.62% | |
| 5.93 | 6.70 | 5.93 | 6.47 | +9.11% | |
| 6.03 | 6.03 | 5.76 | 5.93 | -1.66% | |
| 6.07 | 6.07 | 5.84 | 6.03 | +1.34% | |
| 6.01 | 6.22 | 5.85 | 5.95 | +3.12% | |
| 5.61 | 6.06 | 5.51 | 5.77 | +2.67% | |
| 6.01 | 6.15 | 5.60 | 5.62 | +2.18% | |
| 5.91 | 5.95 | 5.50 | 5.50 | — |
Prices are adjusted for stock splits. See adjusted closing price for how dividends and splits affect history, and the KPTI chart for longer ranges.