Upstream Bio Stock Price History
NASDAQ: UPBHealth CareBiotechnology: Pharmaceutical PreparationsUSD
4.70+0.15 (+3.30%)
At close: Oct 9, 4:00 PM ET · Delayed 15 min
UPB price history at a glance
The price history for Upstream Bio (UPB) on this page begins on October 7, 2024, when the stock closed at $22.00; it most recently closed at $4.70 on October 5, 2026. The highest price in this record is $33.68, reached on January 12, 2026; the latest close is 86.0% below that peak. In the last 12 months alone, UPB has lost 76.3%.
Prices are split-adjusted closing prices; daily open, high, low, close and volume for the past year are listed below.
Summary generated from market data by MetaCap's automated system. Methodology
Key price levels
- High since 2024
- $33.68
- Date of high
- Jan 12, 2026
- Low since 2024
- $4.37
- Date of low
- Oct 5, 2026
- 52-week high
- $33.68
- 52-week low
- $4.37
- IPO year
- 2024
- Last close
- $4.70
UPB returns
1 week
-6.75%
1 month
-21.14%
3 months
-37.58%
6 months
-55.20%
Year to date
-82.69%
1 year
-76.25%
UPB price return, excluding dividends.
UPB annual returns
| Year | Year-end close | Return |
|---|---|---|
| 2026 | 4.70 | -82.64% |
| 2025 | 27.07 | +47.52% |
| 2024* | 18.35 | -16.59% |
* Partial year: the record begins after the start of 2024; return measured from the first available close.
2026 return is year to date.
UPB daily prices (past year)
| Date | Open | High | Low | Close | Change |
|---|---|---|---|---|---|
| 4.54 | 4.76 | 4.52 | 4.70 | +3.30% | |
| 4.53 | 4.65 | 4.37 | 4.55 | -1.30% | |
| 4.55 | 4.72 | 4.50 | 4.61 | +0.44% | |
| 4.84 | 4.87 | 4.53 | 4.59 | -5.36% | |
| 5.07 | 5.10 | 4.67 | 4.85 | -3.77% | |
| 5.12 | 5.21 | 4.86 | 5.04 | 0.00% | |
| 5.25 | 5.35 | 4.98 | 5.04 | -4.36% | |
| 5.23 | 5.46 | 5.15 | 5.27 | +1.54% | |
| 5.28 | 5.31 | 4.99 | 5.19 | -2.08% | |
| 5.34 | 5.39 | 5.12 | 5.30 | -1.12% | |
| 5.20 | 5.39 | 5.07 | 5.36 | +3.68% | |
| 5.19 | 5.20 | 5.05 | 5.17 | -0.39% | |
| 5.48 | 5.49 | 4.99 | 5.19 | -5.46% | |
| 5.44 | 5.56 | 5.38 | 5.49 | +2.33% | |
| 5.42 | 5.44 | 5.27 | 5.37 | +0.47% | |
| 5.32 | 5.41 | 5.21 | 5.34 | +0.56% | |
| 5.44 | 5.48 | 5.24 | 5.31 | -0.38% | |
| 5.49 | 5.54 | 5.27 | 5.33 | -2.74% | |
| 5.81 | 5.81 | 5.46 | 5.48 | -5.68% | |
| 5.75 | 5.87 | 5.70 | 5.81 | +1.40% | |
| 5.84 | 5.84 | 5.65 | 5.73 | -0.35% | |
| 5.86 | 5.86 | 5.67 | 5.75 | -3.52% | |
| 6.14 | 6.20 | 5.77 | 5.96 | -3.72% | |
| 6.01 | 6.21 | 5.77 | 6.19 | +3.00% | |
| 6.00 | 6.23 | 5.97 | 6.01 | -1.15% | |
| 6.49 | 6.49 | 5.77 | 6.08 | -6.17% | |
| 6.62 | 6.98 | 6.41 | 6.48 | -1.07% | |
| 6.58 | 6.72 | 6.50 | 6.55 | -1.06% | |
| 6.64 | 6.77 | 6.44 | 6.62 | -1.05% | |
| 6.71 | 6.79 | 6.60 | 6.69 | -1.47% | |
| 7.11 | 7.14 | 6.78 | 6.79 | -4.77% | |
| 7.18 | 7.31 | 6.90 | 7.13 | -0.70% | |
| 6.68 | 7.18 | 6.55 | 7.18 | +8.62% | |
| 7.00 | 7.11 | 6.46 | 6.61 | -5.16% | |
| 6.91 | 7.01 | 6.85 | 6.97 | +1.75% | |
| 7.48 | 7.56 | 6.75 | 6.85 | -8.85% | |
| 7.04 | 7.53 | 6.91 | 7.52 | +9.71% | |
| 7.28 | 7.44 | 6.73 | 6.85 | -4.06% | |
| 7.02 | 7.19 | 6.86 | 7.14 | +0.99% | |
| 6.95 | 7.14 | 6.80 | 7.07 | +2.32% | |
| 7.02 | 7.04 | 6.87 | 6.91 | 0.00% | |
| 7.00 | 7.25 | 6.84 | 6.91 | -2.54% | |
| 7.48 | 7.70 | 7.01 | 7.09 | -4.70% | |
| 7.32 | 7.62 | 7.20 | 7.44 | +2.62% | |
| 6.94 | 7.26 | 6.89 | 7.25 | +5.53% | |
| 6.75 | 7.17 | 6.66 | 6.87 | +1.93% | |
| 6.77 | 6.88 | 6.58 | 6.74 | -0.74% | |
| 6.40 | 6.92 | 6.40 | 6.79 | +5.76% | |
| 6.31 | 6.43 | 6.18 | 6.42 | +1.74% | |
| 6.58 | 6.69 | 6.29 | 6.31 | -3.96% | |
| 6.35 | 6.67 | 6.29 | 6.57 | +2.50% | |
| 6.39 | 6.48 | 6.21 | 6.41 | +0.16% | |
| 6.40 | 6.54 | 6.09 | 6.40 | 0.00% | |
| 6.47 | 6.60 | 6.26 | 6.40 | -0.16% | |
| 6.40 | 6.61 | 6.16 | 6.41 | +0.16% | |
| 6.46 | 6.59 | 6.32 | 6.40 | -2.88% | |
| 6.95 | 6.99 | 6.47 | 6.59 | -5.59% | |
| 6.92 | 7.08 | 6.86 | 6.98 | 0.00% | |
| 6.99 | 7.15 | 6.80 | 6.98 | -0.43% | |
| 7.08 | 7.30 | 6.90 | 7.01 | -3.04% | |
| 7.24 | 7.34 | 6.98 | 7.23 | -0.55% | |
| 7.12 | 7.32 | 7.08 | 7.27 | +1.82% | |
| 7.28 | 7.34 | 7.00 | 7.14 | -1.92% | |
| 7.47 | 7.53 | 7.02 | 7.28 | -3.32% | |
| 7.81 | 7.81 | 7.28 | 7.53 | -3.59% | |
| 7.98 | 8.00 | 7.57 | 7.81 | -2.13% | |
| 7.73 | 8.00 | 7.53 | 7.98 | +1.53% | |
| 7.48 | 8.00 | 7.32 | 7.86 | +6.22% | |
| 7.50 | 7.59 | 7.34 | 7.40 | -1.46% | |
| 7.31 | 7.72 | 7.16 | 7.51 | +3.16% | |
| 6.90 | 7.42 | 6.81 | 7.28 | +5.20% | |
| 6.94 | 7.38 | 6.88 | 6.92 | -0.14% | |
| 6.77 | 7.00 | 6.56 | 6.93 | +2.67% | |
| 6.36 | 6.78 | 6.35 | 6.75 | +6.13% | |
| 6.32 | 6.57 | 6.28 | 6.36 | +0.16% | |
| 6.35 | 6.71 | 6.32 | 6.35 | +0.47% | |
| 6.26 | 6.54 | 6.24 | 6.32 | +0.32% | |
| 6.33 | 6.60 | 6.25 | 6.30 | +0.80% | |
| 6.26 | 6.52 | 6.15 | 6.25 | +1.63% | |
| 5.94 | 6.33 | 5.88 | 6.15 | +3.89% | |
| 6.10 | 6.19 | 5.86 | 5.92 | -2.95% | |
| 6.19 | 6.28 | 6.01 | 6.10 | 0.00% | |
| 6.03 | 6.47 | 5.85 | 6.10 | -4.39% | |
| 6.28 | 6.40 | 6.11 | 6.38 | +1.59% | |
| 6.64 | 6.80 | 6.25 | 6.28 | -6.13% | |
| 6.53 | 6.78 | 6.42 | 6.69 | +3.72% | |
| 7.16 | 7.16 | 6.41 | 6.45 | -8.51% | |
| 7.39 | 7.45 | 6.98 | 7.05 | -5.11% | |
| 7.68 | 7.78 | 7.30 | 7.43 | -2.62% | |
| 7.52 | 7.86 | 7.40 | 7.63 | +5.24% | |
| 7.96 | 7.96 | 7.19 | 7.25 | -10.27% | |
| 8.33 | 8.64 | 7.99 | 8.08 | -3.35% | |
| 8.31 | 8.50 | 8.17 | 8.36 | +0.48% | |
| 8.24 | 8.38 | 8.13 | 8.32 | +0.73% | |
| 8.19 | 8.55 | 8.19 | 8.26 | +0.61% | |
| 8.44 | 8.45 | 8.11 | 8.21 | -1.91% | |
| 8.47 | 8.69 | 8.33 | 8.37 | -1.06% | |
| 8.35 | 8.60 | 8.25 | 8.46 | +0.59% | |
| 8.02 | 8.56 | 7.99 | 8.41 | +4.73% | |
| 8.42 | 8.64 | 8.02 | 8.03 | -5.64% | |
| 8.97 | 9.13 | 8.12 | 8.51 | -6.38% | |
| 8.59 | 9.14 | 8.55 | 9.09 | +3.41% | |
| 9.45 | 9.52 | 8.51 | 8.79 | -6.09% | |
| 8.96 | 9.47 | 8.80 | 9.36 | +4.58% | |
| 8.93 | 9.14 | 8.83 | 8.95 | -1.76% | |
| 9.20 | 9.60 | 9.05 | 9.11 | +0.22% | |
| 8.88 | 9.35 | 8.80 | 9.09 | +1.17% | |
| 9.14 | 9.14 | 8.69 | 8.99 | -2.23% | |
| 9.16 | 9.29 | 8.98 | 9.19 | +0.77% | |
| 9.31 | 9.50 | 8.88 | 9.12 | -2.04% | |
| 9.34 | 9.57 | 9.16 | 9.31 | -0.96% | |
| 9.25 | 9.41 | 9.12 | 9.40 | +2.40% | |
| 9.20 | 9.30 | 9.06 | 9.18 | -0.11% | |
| 9.32 | 9.37 | 8.97 | 9.19 | -3.36% | |
| 9.32 | 9.65 | 9.28 | 9.51 | +2.37% | |
| 9.22 | 9.64 | 9.15 | 9.29 | -0.11% | |
| 9.47 | 9.63 | 9.21 | 9.30 | -3.12% | |
| 9.62 | 9.72 | 9.38 | 9.60 | -0.41% | |
| 9.31 | 9.71 | 9.06 | 9.64 | +4.10% | |
| 10.01 | 10.05 | 9.22 | 9.26 | -7.31% | |
| 9.98 | 10.09 | 9.79 | 9.99 | 0.00% | |
| 10.45 | 10.64 | 9.84 | 9.99 | -1.09% | |
| 9.88 | 10.15 | 9.68 | 10.10 | +2.23% | |
| 10.40 | 10.52 | 9.79 | 9.88 | -4.45% | |
| 10.14 | 10.45 | 10.08 | 10.34 | +1.08% | |
| 10.45 | 10.61 | 10.09 | 10.23 | -2.48% | |
| 10.48 | 10.67 | 10.34 | 10.49 | +0.67% | |
| 9.67 | 10.49 | 9.63 | 10.42 | +5.89% | |
| 9.87 | 10.00 | 9.45 | 9.84 | +1.44% | |
| 9.59 | 9.71 | 9.31 | 9.70 | -0.21% | |
| 9.49 | 9.89 | 9.36 | 9.72 | +2.32% | |
| 9.06 | 9.64 | 8.97 | 9.50 | +2.04% | |
| 9.22 | 9.35 | 8.96 | 9.31 | +3.44% | |
| 9.01 | 9.17 | 8.82 | 9.00 | +2.51% | |
| 8.53 | 8.78 | 8.29 | 8.78 | +1.27% | |
| 8.72 | 9.15 | 8.10 | 8.67 | -11.44% | |
| 9.48 | 10.43 | 9.38 | 9.79 | +3.38% | |
| 8.68 | 9.57 | 8.67 | 9.47 | +12.07% | |
| 8.35 | 8.62 | 8.12 | 8.45 | 0.00% | |
| 8.71 | 9.03 | 8.43 | 8.45 | -2.54% | |
| 8.38 | 8.68 | 8.16 | 8.67 | +3.46% | |
| 8.44 | 8.63 | 8.23 | 8.38 | -3.29% | |
| 9.58 | 9.70 | 8.66 | 8.67 | -10.76% | |
| 9.58 | 9.90 | 9.17 | 9.71 | +1.04% | |
| 9.29 | 9.68 | 9.27 | 9.61 | +4.12% | |
| 9.32 | 9.76 | 8.93 | 9.23 | -2.17% | |
| 9.27 | 9.47 | 8.70 | 9.44 | +0.80% | |
| 8.16 | 9.37 | 8.16 | 9.36 | +15.27% | |
| 8.15 | 8.36 | 7.99 | 8.12 | +0.74% | |
| 7.65 | 8.09 | 7.64 | 8.06 | +5.22% | |
| 7.47 | 7.77 | 7.40 | 7.66 | -0.13% | |
| 7.64 | 7.78 | 7.40 | 7.67 | -1.67% | |
| 7.37 | 8.01 | 7.33 | 7.80 | +5.98% | |
| 7.59 | 7.64 | 7.25 | 7.36 | -4.42% | |
| 7.51 | 7.92 | 7.46 | 7.70 | +0.26% | |
| 7.87 | 8.07 | 7.62 | 7.68 | -2.78% | |
| 7.74 | 8.32 | 7.70 | 7.90 | +2.07% | |
| 7.90 | 8.10 | 7.70 | 7.74 | -2.27% | |
| 8.05 | 8.27 | 7.78 | 7.92 | -1.25% | |
| 8.09 | 8.32 | 7.74 | 8.02 | -0.74% | |
| 8.41 | 8.69 | 8.01 | 8.08 | -5.39% | |
| 8.32 | 8.73 | 8.14 | 8.54 | +3.02% | |
| 8.18 | 8.66 | 7.93 | 8.29 | -0.48% | |
| 8.69 | 9.00 | 7.96 | 8.33 | -4.80% | |
| 12.69 | 12.69 | 8.52 | 8.75 | -31.64% | |
| 14.86 | 14.86 | 12.75 | 12.80 | -12.87% | |
| 19.00 | 20.01 | 12.65 | 14.69 | -47.18% | |
| 26.10 | 28.58 | 25.93 | 27.81 | +6.47% | |
| 26.24 | 26.24 | 25.16 | 26.12 | -0.31% | |
| 26.56 | 27.98 | 25.94 | 26.20 | +0.77% | |
| 29.40 | 30.31 | 25.87 | 26.00 | -11.50% | |
| 30.88 | 30.88 | 28.35 | 29.38 | -4.58% | |
| 30.38 | 31.05 | 29.82 | 30.79 | +2.84% | |
| 31.10 | 32.38 | 29.64 | 29.94 | -3.67% | |
| 30.64 | 31.37 | 29.71 | 31.08 | +0.45% | |
| 30.30 | 31.12 | 29.61 | 30.94 | +1.68% | |
| 32.50 | 32.50 | 29.99 | 30.43 | -6.37% | |
| 30.24 | 32.83 | 30.13 | 32.50 | +7.76% | |
| 29.77 | 30.91 | 29.76 | 30.16 | +0.47% | |
| 31.62 | 31.62 | 29.83 | 30.02 | -5.57% | |
| 31.74 | 32.52 | 31.70 | 31.79 | +0.63% | |
| 30.95 | 32.14 | 30.31 | 31.59 | +1.90% | |
| 30.22 | 31.52 | 29.08 | 31.00 | 0.00% | |
| 31.06 | 31.64 | 29.80 | 31.00 | +0.32% | |
| 32.42 | 32.42 | 30.74 | 30.90 | -4.33% | |
| 32.68 | 33.68 | 31.95 | 32.30 | -0.92% | |
| 31.71 | 32.66 | 30.48 | 32.60 | +2.97% | |
| 29.73 | 31.93 | 29.34 | 31.66 | +6.42% | |
| 27.87 | 30.60 | 27.87 | 29.75 | +8.02% | |
| 27.71 | 28.49 | 27.22 | 27.54 | -1.92% | |
| 26.08 | 28.16 | 26.08 | 28.08 | +8.54% | |
| 25.93 | 26.52 | 25.00 | 25.87 | -1.00% | |
| 27.07 | 27.39 | 25.25 | 26.13 | -3.47% | |
| 27.30 | 28.01 | 26.72 | 27.07 | -0.29% | |
| 27.17 | 27.58 | 26.86 | 27.15 | -0.62% | |
| 28.77 | 28.77 | 26.86 | 27.32 | -5.24% | |
| 29.48 | 29.92 | 28.70 | 28.83 | -2.20% | |
| 30.11 | 30.11 | 29.10 | 29.48 | -2.61% | |
| 29.65 | 30.76 | 29.60 | 30.27 | +3.63% | |
| 30.27 | 30.76 | 29.05 | 29.21 | -4.01% | |
| 29.29 | 30.89 | 29.00 | 30.43 | +3.68% | |
| 30.01 | 30.56 | 29.19 | 29.35 | -1.71% | |
| 29.09 | 30.27 | 28.36 | 29.86 | +5.40% | |
| 29.41 | 29.95 | 28.15 | 28.33 | -3.38% | |
| 26.92 | 29.73 | 26.03 | 29.32 | +7.79% | |
| 27.56 | 27.95 | 26.68 | 27.20 | +0.22% | |
| 28.00 | 28.25 | 26.78 | 27.14 | -1.20% | |
| 28.72 | 29.51 | 27.16 | 27.47 | -4.19% | |
| 28.37 | 29.55 | 27.93 | 28.67 | +1.08% | |
| 28.73 | 29.17 | 27.99 | 28.37 | -2.09% | |
| 28.03 | 29.50 | 27.91 | 28.97 | +4.40% | |
| 27.82 | 28.43 | 27.00 | 27.75 | +0.04% | |
| 26.69 | 28.45 | 26.69 | 27.74 | +2.86% | |
| 25.01 | 27.15 | 24.94 | 26.97 | +7.84% | |
| 29.61 | 29.89 | 24.61 | 25.01 | -13.70% | |
| 28.32 | 29.08 | 28.07 | 28.98 | +1.33% | |
| 28.14 | 28.89 | 28.06 | 28.60 | +2.14% | |
| 29.12 | 33.00 | 27.90 | 28.00 | -2.88% | |
| 26.22 | 29.29 | 25.84 | 28.83 | +10.67% | |
| 25.35 | 26.99 | 25.32 | 26.05 | +1.96% | |
| 24.71 | 26.10 | 24.12 | 25.55 | +2.36% | |
| 25.37 | 26.19 | 24.75 | 24.96 | +0.08% | |
| 25.31 | 25.80 | 24.10 | 24.94 | -2.43% | |
| 26.20 | 26.20 | 25.07 | 25.56 | -0.54% | |
| 24.39 | 26.15 | 24.14 | 25.70 | +4.77% | |
| 23.08 | 25.10 | 23.01 | 24.53 | +5.10% | |
| 23.52 | 23.99 | 22.99 | 23.34 | -1.60% | |
| 23.74 | 24.95 | 23.22 | 23.72 | -0.25% | |
| 23.31 | 24.80 | 22.89 | 23.78 | +1.19% | |
| 23.52 | 23.87 | 22.59 | 23.50 | +2.35% | |
| 23.64 | 23.64 | 21.98 | 22.96 | -2.96% | |
| 24.00 | 24.58 | 23.03 | 23.66 | -1.29% | |
| 25.44 | 25.65 | 23.66 | 23.97 | -4.27% | |
| 24.27 | 25.57 | 24.02 | 25.04 | +0.08% | |
| 25.92 | 26.22 | 24.76 | 25.02 | -3.21% | |
| 25.70 | 26.25 | 25.48 | 25.85 | +0.31% | |
| 23.93 | 26.90 | 23.93 | 25.77 | +6.53% | |
| 24.82 | 25.33 | 23.95 | 24.19 | -2.62% | |
| 23.50 | 25.09 | 23.50 | 24.84 | +5.34% | |
| 21.97 | 24.00 | 21.89 | 23.58 | +7.87% | |
| 21.45 | 22.14 | 21.44 | 21.86 | +3.45% | |
| 22.12 | 22.42 | 21.02 | 21.13 | -4.60% | |
| 22.22 | 22.62 | 21.90 | 22.15 | -0.81% | |
| 23.03 | 23.03 | 22.14 | 22.33 | -3.12% | |
| 21.37 | 23.34 | 21.17 | 23.05 | +9.92% | |
| 21.86 | 22.15 | 20.65 | 20.97 | -5.88% | |
| 21.79 | 22.39 | 21.39 | 22.28 | +2.72% | |
| 20.12 | 21.87 | 20.12 | 21.69 | +8.56% | |
| 20.65 | 20.65 | 19.63 | 19.98 | -0.50% | |
| 19.79 | 20.31 | 19.56 | 20.08 | +2.34% | |
| 19.80 | 20.68 | 19.46 | 19.62 | -0.86% | |
| 18.90 | 20.09 | 18.61 | 19.79 | — |
Prices are adjusted for stock splits. See adjusted closing price for how dividends and splits affect history, and the UPB chart for longer ranges.