Spyre Therapeutics Stock Price History
NASDAQ: SYREHealth CareBiotechnology: Pharmaceutical PreparationsUSD
85.69+5.79 (+7.25%)
At close: Oct 9, 4:00 PM ET · Delayed 15 min
SYRE price history at a glance
The price history for Spyre Therapeutics (SYRE) on this page begins on April 4, 2016, when the stock closed at $299.75; it most recently closed at $85.69 on October 5, 2026. The highest price in this record is $318.75, reached on April 4, 2016; the latest close is 73.1% below that peak. Across the 9 complete calendar years in the table, SYRE finished higher in 6 and lower in 3. Its best year was 2023 (+91.3%) and its worst was 2022 (-90.5%).
Over roughly 11 years the share price changed -71.4%, a -11.2% compound annual price return (excluding dividends). In the last 12 months alone, SYRE has gained 353.0%. Prices are split-adjusted closing prices; daily open, high, low, close and volume for the past year are listed below.
Summary generated from market data by MetaCap's automated system. Methodology
Key price levels
- High since 2016
- $318.75
- Date of high
- Apr 4, 2016
- Low since 2016
- $2.65
- Date of low
- Jun 19, 2023
- 52-week high
- $110.18
- 52-week low
- $18.12
- IPO year
- 2016
- Last close
- $85.69
SYRE returns
1 week
-8.05%
1 month
-1.43%
3 months
-12.33%
6 months
+67.07%
Year to date
+161.57%
1 year
+353.03%
3 years
+560.17%
5 years
-58.10%
SYRE price return, excluding dividends.
SYRE annual returns
| Year | Year-end close | Return |
|---|---|---|
| 2026 | 85.69 | +180.22% |
| 2025 | 30.58 | +25.59% |
| 2024 | 24.35 | +13.15% |
| 2023 | 21.52 | +91.29% |
| 2022 | 11.25 | -90.53% |
| 2021 | 118.75 | -39.64% |
| 2020 | 196.75 | +2.34% |
| 2019 | 192.25 | -8.67% |
| 2018 | 210.50 | +55.64% |
| 2017 | 135.25 | +24.37% |
| 2016* | 108.75 | -63.72% |
* Partial year: the record begins after the start of 2016; return measured from the first available close.
2026 return is year to date.
SYRE daily prices (past year)
| Date | Open | High | Low | Close | Change |
|---|---|---|---|---|---|
| 79.90 | 86.22 | 78.73 | 85.69 | +7.25% | |
| 79.58 | 80.91 | 77.05 | 79.90 | -1.18% | |
| 78.33 | 82.21 | 78.00 | 80.85 | +0.92% | |
| 92.08 | 92.08 | 79.36 | 80.11 | -13.60% | |
| 93.02 | 95.01 | 89.49 | 92.72 | -0.50% | |
| 91.16 | 95.27 | 90.48 | 93.19 | +3.63% | |
| 89.13 | 94.06 | 87.25 | 89.93 | +1.01% | |
| 88.64 | 95.08 | 88.00 | 89.03 | +5.09% | |
| 85.09 | 86.64 | 83.26 | 84.72 | -1.25% | |
| 84.72 | 87.12 | 84.00 | 85.79 | +0.12% | |
| 88.10 | 88.10 | 85.63 | 85.69 | -1.61% | |
| 87.46 | 87.46 | 82.93 | 87.09 | -1.22% | |
| 91.56 | 91.56 | 86.30 | 88.17 | -4.13% | |
| 91.53 | 93.58 | 89.90 | 91.97 | -0.07% | |
| 91.07 | 94.06 | 89.65 | 92.03 | +1.97% | |
| 92.82 | 93.34 | 89.85 | 90.25 | -2.62% | |
| 92.86 | 95.19 | 91.14 | 92.68 | +1.66% | |
| 91.38 | 93.07 | 90.48 | 91.17 | +0.24% | |
| 90.82 | 91.07 | 88.47 | 90.95 | +0.17% | |
| 90.21 | 91.40 | 89.43 | 90.80 | +0.22% | |
| 90.00 | 91.41 | 87.89 | 90.60 | +2.13% | |
| 85.56 | 88.72 | 85.26 | 88.71 | +2.05% | |
| 88.07 | 89.57 | 86.85 | 86.93 | -4.25% | |
| 85.00 | 92.10 | 85.00 | 90.79 | +2.03% | |
| 86.45 | 89.18 | 84.68 | 88.98 | +1.98% | |
| 86.71 | 87.90 | 85.78 | 87.25 | +0.23% | |
| 88.05 | 90.18 | 84.00 | 87.05 | -1.64% | |
| 87.06 | 90.00 | 85.00 | 88.50 | -0.93% | |
| 89.15 | 90.97 | 86.40 | 89.33 | -1.14% | |
| 91.75 | 93.39 | 89.45 | 90.36 | -3.48% | |
| 93.61 | 94.95 | 91.25 | 93.62 | +0.01% | |
| 92.41 | 96.22 | 90.60 | 93.61 | -12.81% | |
| 109.02 | 110.15 | 106.94 | 107.36 | +0.67% | |
| 106.49 | 108.02 | 104.94 | 106.65 | +0.15% | |
| 108.85 | 110.00 | 105.71 | 106.49 | -1.21% | |
| 106.60 | 108.18 | 104.56 | 107.79 | -1.04% | |
| 110.00 | 110.18 | 104.17 | 108.92 | +1.02% | |
| 102.46 | 108.62 | 101.44 | 107.82 | +3.08% | |
| 102.94 | 104.96 | 102.26 | 104.60 | +0.94% | |
| 101.21 | 104.13 | 95.61 | 103.63 | +1.75% | |
| 101.00 | 103.84 | 100.90 | 101.85 | -2.15% | |
| 105.06 | 105.06 | 99.00 | 104.09 | +1.31% | |
| 105.33 | 105.44 | 99.84 | 102.74 | -2.46% | |
| 106.19 | 107.00 | 103.33 | 105.33 | +0.40% | |
| 106.01 | 106.67 | 103.64 | 104.91 | +1.44% | |
| 102.39 | 106.75 | 101.64 | 103.42 | -0.89% | |
| 104.94 | 108.14 | 100.88 | 104.35 | -0.56% | |
| 98.27 | 105.25 | 97.03 | 104.94 | +10.54% | |
| 97.15 | 99.58 | 92.71 | 94.93 | -3.46% | |
| 100.58 | 100.58 | 95.27 | 98.33 | -3.12% | |
| 98.26 | 101.88 | 97.39 | 101.50 | +3.71% | |
| 99.38 | 100.99 | 94.52 | 97.87 | -2.09% | |
| 97.19 | 100.93 | 92.37 | 99.96 | -0.08% | |
| 102.01 | 105.05 | 98.87 | 100.04 | -2.05% | |
| 100.56 | 103.57 | 98.79 | 102.13 | +2.14% | |
| 97.06 | 100.35 | 97.00 | 99.99 | +0.83% | |
| 102.39 | 102.39 | 99.07 | 99.17 | -3.44% | |
| 99.07 | 103.31 | 98.50 | 102.70 | +5.52% | |
| 101.02 | 102.92 | 97.28 | 97.33 | -2.89% | |
| 94.26 | 101.36 | 92.37 | 100.23 | +6.49% | |
| 103.32 | 103.32 | 93.37 | 94.12 | -7.79% | |
| 100.21 | 102.58 | 95.14 | 102.07 | +3.15% | |
| 96.06 | 105.09 | 94.96 | 98.95 | +5.57% | |
| 95.72 | 96.82 | 92.67 | 93.73 | -4.10% | |
| 98.75 | 99.34 | 94.13 | 97.74 | -1.02% | |
| 96.36 | 99.00 | 96.11 | 98.75 | +3.51% | |
| 94.36 | 95.59 | 90.65 | 95.40 | +1.24% | |
| 90.00 | 95.16 | 86.60 | 94.23 | +6.19% | |
| 87.27 | 91.89 | 86.61 | 88.74 | +2.44% | |
| 89.11 | 89.69 | 85.17 | 86.63 | -2.54% | |
| 88.21 | 89.02 | 86.41 | 88.89 | +0.12% | |
| 90.30 | 91.96 | 88.60 | 88.78 | -1.53% | |
| 86.56 | 90.90 | 84.81 | 90.16 | +2.58% | |
| 91.00 | 91.00 | 85.97 | 87.89 | -0.88% | |
| 86.46 | 89.67 | 84.96 | 88.67 | +2.82% | |
| 83.22 | 88.15 | 81.65 | 86.24 | -11.14% | |
| 97.72 | 102.06 | 95.31 | 97.05 | -3.26% | |
| 95.00 | 101.71 | 95.00 | 100.32 | +13.56% | |
| 89.55 | 90.99 | 86.18 | 88.34 | +0.97% | |
| 84.97 | 88.03 | 83.17 | 87.49 | +4.89% | |
| 83.54 | 84.93 | 81.70 | 83.41 | -0.20% | |
| 81.57 | 84.69 | 80.79 | 83.58 | +3.45% | |
| 81.09 | 84.43 | 80.72 | 80.79 | +0.02% | |
| 75.74 | 81.62 | 75.35 | 80.77 | +7.58% | |
| 77.18 | 79.52 | 74.79 | 75.08 | -1.78% | |
| 73.65 | 77.11 | 70.89 | 76.44 | +6.17% | |
| 75.53 | 76.31 | 71.11 | 72.00 | -2.24% | |
| 77.77 | 78.90 | 73.06 | 73.65 | -6.15% | |
| 73.57 | 79.54 | 73.29 | 78.48 | +6.75% | |
| 70.33 | 76.11 | 69.82 | 73.52 | +6.30% | |
| 69.99 | 70.50 | 68.50 | 69.16 | -1.96% | |
| 72.39 | 73.21 | 68.85 | 70.54 | -4.03% | |
| 72.11 | 74.36 | 71.51 | 73.50 | +1.93% | |
| 72.36 | 73.33 | 71.08 | 72.11 | -0.55% | |
| 73.99 | 74.35 | 72.24 | 72.51 | -1.55% | |
| 74.87 | 76.12 | 72.11 | 73.65 | -0.54% | |
| 75.34 | 75.63 | 73.11 | 74.05 | -0.36% | |
| 70.89 | 74.43 | 70.18 | 74.32 | +3.34% | |
| 68.64 | 72.47 | 67.88 | 71.92 | +7.96% | |
| 70.08 | 70.08 | 64.67 | 66.62 | -4.94% | |
| 75.08 | 75.65 | 69.01 | 70.08 | -6.46% | |
| 77.08 | 77.08 | 72.54 | 74.92 | -0.96% | |
| 76.51 | 77.76 | 74.49 | 75.65 | -0.86% | |
| 75.69 | 78.00 | 73.48 | 76.31 | +1.69% | |
| 77.00 | 77.20 | 73.22 | 75.04 | -1.82% | |
| 75.15 | 78.80 | 74.39 | 76.43 | +1.85% | |
| 73.10 | 75.91 | 72.40 | 75.05 | +2.66% | |
| 73.58 | 74.51 | 71.13 | 73.10 | +0.14% | |
| 70.68 | 73.51 | 70.11 | 73.00 | +2.80% | |
| 70.65 | 73.22 | 70.21 | 71.01 | +2.72% | |
| 68.26 | 71.67 | 67.18 | 69.13 | -0.42% | |
| 74.09 | 76.00 | 69.17 | 69.42 | -6.76% | |
| 72.33 | 75.00 | 72.08 | 74.45 | +3.56% | |
| 68.25 | 73.62 | 67.50 | 71.89 | +4.75% | |
| 72.10 | 73.96 | 68.20 | 68.63 | -4.55% | |
| 69.53 | 72.30 | 69.53 | 71.90 | +3.20% | |
| 69.83 | 72.07 | 68.43 | 69.67 | +0.62% | |
| 73.01 | 73.73 | 68.33 | 69.24 | -5.15% | |
| 72.96 | 74.35 | 71.71 | 73.00 | +2.43% | |
| 73.39 | 74.84 | 69.95 | 71.27 | -2.89% | |
| 72.20 | 74.68 | 72.03 | 73.39 | +0.52% | |
| 70.32 | 74.60 | 70.21 | 73.01 | +4.75% | |
| 68.94 | 70.30 | 66.88 | 69.70 | +1.03% | |
| 67.75 | 69.45 | 64.60 | 68.99 | +7.78% | |
| 67.68 | 67.68 | 60.75 | 64.01 | +1.17% | |
| 67.00 | 75.00 | 59.02 | 63.27 | +23.36% | |
| 51.40 | 52.98 | 50.85 | 51.29 | -0.93% | |
| 51.63 | 52.77 | 51.20 | 51.77 | -0.40% | |
| 52.70 | 54.39 | 50.39 | 51.98 | +1.52% | |
| 48.97 | 51.26 | 48.83 | 51.20 | +4.53% | |
| 47.58 | 49.85 | 46.79 | 48.98 | +2.94% | |
| 47.17 | 48.40 | 46.27 | 47.58 | -2.70% | |
| 50.33 | 51.00 | 48.64 | 48.90 | -3.05% | |
| 46.28 | 51.06 | 46.28 | 50.44 | +11.05% | |
| 47.75 | 48.47 | 44.80 | 45.42 | -3.99% | |
| 46.93 | 47.95 | 46.70 | 47.31 | -0.44% | |
| 45.39 | 49.31 | 45.23 | 47.52 | +4.03% | |
| 42.93 | 45.79 | 42.68 | 45.68 | +8.20% | |
| 41.78 | 42.76 | 40.91 | 42.22 | -1.26% | |
| 42.02 | 44.08 | 41.73 | 42.76 | +3.66% | |
| 42.11 | 43.22 | 41.16 | 41.25 | -2.51% | |
| 42.98 | 43.22 | 41.74 | 42.31 | -1.74% | |
| 44.28 | 44.28 | 42.36 | 43.06 | -2.03% | |
| 44.25 | 45.39 | 43.77 | 43.95 | -0.27% | |
| 40.73 | 44.49 | 40.73 | 44.07 | +10.48% | |
| 40.92 | 42.40 | 39.00 | 39.89 | -1.29% | |
| 40.22 | 40.75 | 39.20 | 40.41 | -2.63% | |
| 41.25 | 42.61 | 41.06 | 41.50 | -0.17% | |
| 41.09 | 42.93 | 41.09 | 41.57 | +1.22% | |
| 39.75 | 41.88 | 39.21 | 41.07 | +2.29% | |
| 39.99 | 40.59 | 38.36 | 40.15 | -1.08% | |
| 40.34 | 41.50 | 39.90 | 40.59 | -1.00% | |
| 40.14 | 42.58 | 40.07 | 41.00 | +2.32% | |
| 40.99 | 41.85 | 39.98 | 40.07 | -5.70% | |
| 41.27 | 42.93 | 40.74 | 42.49 | -1.21% | |
| 42.42 | 43.80 | 42.27 | 43.01 | -0.32% | |
| 43.79 | 44.26 | 42.03 | 43.15 | -1.66% | |
| 44.18 | 44.88 | 43.43 | 43.88 | +0.99% | |
| 44.17 | 44.81 | 43.05 | 43.45 | -1.65% | |
| 43.01 | 45.76 | 42.26 | 44.18 | +2.24% | |
| 37.82 | 43.56 | 37.81 | 43.21 | +14.28% | |
| 36.66 | 38.16 | 35.93 | 37.81 | +3.31% | |
| 36.05 | 37.66 | 35.93 | 36.60 | +1.81% | |
| 36.39 | 37.22 | 34.96 | 35.95 | -1.86% | |
| 35.02 | 37.98 | 35.02 | 36.63 | +5.14% | |
| 33.98 | 34.92 | 33.59 | 34.84 | +2.71% | |
| 33.59 | 34.13 | 32.35 | 33.92 | +1.07% | |
| 34.28 | 34.93 | 33.19 | 33.56 | -1.18% | |
| 35.12 | 35.58 | 33.78 | 33.96 | -3.30% | |
| 33.77 | 35.21 | 33.16 | 35.12 | +6.62% | |
| 31.85 | 33.67 | 31.40 | 32.94 | +2.71% | |
| 33.57 | 34.07 | 30.92 | 32.07 | -3.66% | |
| 32.77 | 33.96 | 32.66 | 33.29 | +1.65% | |
| 31.76 | 33.35 | 30.99 | 32.75 | +2.41% | |
| 33.27 | 33.65 | 31.60 | 31.98 | -4.76% | |
| 32.96 | 33.77 | 32.83 | 33.58 | +1.33% | |
| 33.45 | 34.03 | 32.49 | 33.14 | -0.66% | |
| 32.31 | 33.77 | 32.31 | 33.36 | +3.31% | |
| 31.52 | 33.08 | 31.52 | 32.29 | +0.80% | |
| 33.05 | 34.47 | 31.78 | 32.04 | -6.03% | |
| 33.87 | 35.07 | 33.82 | 34.09 | +0.29% | |
| 33.68 | 34.51 | 33.33 | 33.99 | +0.77% | |
| 32.34 | 33.92 | 31.62 | 33.73 | +1.47% | |
| 33.20 | 34.00 | 32.40 | 33.24 | +0.45% | |
| 33.26 | 34.17 | 32.57 | 33.09 | -0.21% | |
| 31.53 | 34.21 | 31.53 | 33.16 | +5.17% | |
| 32.95 | 33.71 | 31.03 | 31.53 | -3.87% | |
| 30.60 | 33.10 | 30.00 | 32.80 | +7.15% | |
| 30.46 | 31.45 | 30.36 | 30.61 | +1.56% | |
| 30.42 | 30.71 | 29.60 | 30.14 | -2.93% | |
| 30.45 | 31.69 | 30.21 | 31.05 | +2.37% | |
| 29.92 | 30.39 | 29.43 | 30.33 | +1.23% | |
| 30.49 | 30.55 | 28.00 | 29.96 | -2.03% | |
| 32.76 | 33.31 | 30.11 | 30.58 | -6.65% | |
| 31.78 | 32.84 | 31.52 | 32.76 | +2.76% | |
| 32.45 | 32.53 | 31.50 | 31.88 | -2.09% | |
| 32.77 | 33.22 | 32.05 | 32.56 | -1.15% | |
| 33.00 | 33.03 | 32.30 | 32.94 | -0.33% | |
| 33.38 | 34.10 | 32.79 | 33.05 | -0.54% | |
| 33.84 | 34.44 | 32.96 | 33.23 | -2.84% | |
| 32.93 | 34.52 | 32.50 | 34.20 | +2.40% | |
| 33.82 | 34.84 | 33.22 | 33.40 | -0.21% | |
| 33.66 | 34.24 | 32.88 | 33.47 | +1.24% | |
| 33.51 | 34.32 | 32.76 | 33.06 | +0.27% | |
| 33.00 | 33.52 | 32.26 | 32.97 | -1.11% | |
| 33.93 | 34.96 | 33.15 | 33.34 | -0.83% | |
| 34.36 | 35.17 | 33.24 | 33.62 | -2.15% | |
| 34.77 | 35.31 | 34.17 | 34.36 | -0.87% | |
| 33.70 | 34.94 | 33.51 | 34.66 | +2.91% | |
| 34.48 | 34.98 | 33.52 | 33.68 | -2.74% | |
| 33.95 | 34.96 | 33.45 | 34.63 | +3.53% | |
| 33.56 | 34.06 | 33.00 | 33.45 | -0.18% | |
| 32.18 | 34.54 | 31.44 | 33.51 | +4.07% | |
| 28.85 | 32.26 | 28.50 | 32.20 | +13.38% | |
| 28.85 | 29.84 | 28.16 | 28.40 | -0.91% | |
| 30.55 | 30.55 | 28.45 | 28.66 | -4.47% | |
| 30.00 | 30.21 | 29.75 | 30.00 | +0.84% | |
| 29.21 | 29.78 | 28.71 | 29.75 | +1.88% | |
| 26.73 | 29.50 | 26.64 | 29.20 | +8.27% | |
| 24.95 | 27.21 | 24.58 | 26.97 | +11.17% | |
| 23.29 | 24.97 | 23.01 | 24.26 | +3.37% | |
| 24.77 | 25.42 | 23.22 | 23.47 | -3.42% | |
| 24.52 | 25.07 | 23.69 | 24.30 | +0.83% | |
| 24.18 | 24.70 | 23.75 | 24.10 | -1.07% | |
| 23.47 | 25.02 | 23.03 | 24.36 | +3.66% | |
| 22.26 | 24.50 | 22.13 | 23.50 | +3.84% | |
| 23.13 | 23.57 | 22.47 | 22.63 | -3.41% | |
| 23.39 | 24.19 | 22.91 | 23.43 | +0.34% | |
| 22.21 | 23.68 | 21.63 | 23.35 | +5.28% | |
| 22.93 | 23.00 | 21.96 | 22.18 | -1.51% | |
| 21.88 | 22.54 | 21.15 | 22.52 | +0.58% | |
| 22.53 | 22.99 | 21.88 | 22.39 | -2.01% | |
| 23.37 | 23.50 | 22.03 | 22.85 | -0.57% | |
| 23.29 | 23.56 | 22.87 | 22.98 | -3.36% | |
| 23.95 | 24.45 | 22.42 | 23.78 | -2.78% | |
| 24.10 | 24.59 | 23.65 | 24.46 | +0.82% | |
| 23.79 | 24.68 | 23.78 | 24.26 | +1.80% | |
| 24.48 | 25.01 | 23.52 | 23.83 | -3.29% | |
| 24.30 | 25.06 | 24.29 | 24.64 | +0.28% | |
| 24.01 | 25.00 | 23.65 | 24.57 | +5.13% | |
| 22.56 | 23.59 | 22.35 | 23.37 | +4.47% | |
| 22.19 | 22.89 | 21.90 | 22.37 | +0.72% | |
| 23.11 | 23.40 | 21.88 | 22.21 | -4.47% | |
| 23.50 | 24.03 | 22.84 | 23.25 | -1.02% | |
| 22.86 | 23.53 | 22.23 | 23.49 | +4.54% | |
| 21.93 | 22.98 | 21.90 | 22.47 | +1.03% | |
| 22.04 | 23.49 | 21.82 | 22.24 | +0.23% | |
| 21.60 | 22.31 | 21.01 | 22.19 | +5.67% | |
| 18.91 | 21.61 | 18.71 | 21.00 | +11.02% | |
| 19.15 | 19.71 | 18.12 | 18.92 | — |
Prices are adjusted for stock splits. See adjusted closing price for how dividends and splits affect history, and the SYRE chart for longer ranges.