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Spyre Therapeutics Insider Trades

NASDAQ: SYREHealth CareBiotechnology: Pharmaceutical PreparationsUSD

85.69+5.79 (+7.25%)

At close: Oct 9, 4:00 PM ET · Delayed 15 min

Last 12 months

Purchases
0 · $0
Sales
82 · $439.75M
Shares bought / sold
0 / 5.18M
Net activity
Net selling $439.7 million

Spyre Therapeutics insider activity

Over the last 12 months, Spyre Therapeutics insiders reported 100 transactions on SEC Form 4: 0 open-market purchases and 82 sales. Insiders bought $0 and sold $439.7 million worth of stock, for net insider selling of $439.7 million. The largest seller was Fairmount Funds Management LLC & Fairmount Healthcare Fund II L.P. & Kiselak Tomas & Harwin Peter Evan, with $399.7 million in reported sales.

The most recent filing shows King-Jones Heidy (See Remarks) reporting a transaction in 28,933 shares at $14.50 on Oct 1, 2026. Insider sales are common for compensation, tax and diversification reasons, while open-market purchases are rarer; tracking both helps put SYRE's ownership changes in context.

Summary generated from market data by MetaCap's automated system. Methodology

SYRE insider transactions

Spyre Therapeutics insider transactions
DateInsiderTypeSharesValueFiling
Oct 1, 2026Turtle CameronChief Executive OfficerSale100$9.39KForm 4
Oct 1, 2026Turtle CameronChief Executive OfficerSale4,990$465.92KForm 4
Oct 1, 2026Turtle CameronChief Executive OfficerSale3,989$368.22KForm 4
Oct 1, 2026Turtle CameronChief Executive OfficerSale2,638$241.35KForm 4
Oct 1, 2026Turtle CameronChief Executive OfficerSale2,683$241.74KForm 4
Oct 1, 2026Turtle CameronChief Executive OfficerSale600$53.48KForm 4
Oct 1, 2026Burrows Scott LChief Financial OfficerSale229$21.43KForm 4
Oct 1, 2026Burrows Scott LChief Financial OfficerSale3,071$285.45KForm 4
Oct 1, 2026Burrows Scott LChief Financial OfficerSale2,100$193.03KForm 4
Oct 1, 2026Burrows Scott LChief Financial OfficerSale1,500$135.41KForm 4
Oct 1, 2026Burrows Scott LChief Financial OfficerSale600$53.44KForm 4
Oct 1, 2026Burrows Scott LChief Financial OfficerOption exercise7,500$108.75KForm 4
Oct 1, 2026King-Jones HeidySee RemarksSale2,600$243.00KForm 4
Oct 1, 2026King-Jones HeidySee RemarksSale2,100$194.67KForm 4
Oct 1, 2026King-Jones HeidySee RemarksSale7,228$660.28KForm 4
Oct 1, 2026King-Jones HeidySee RemarksSale16,605$1.50MForm 4
Oct 1, 2026King-Jones HeidySee RemarksSale400$35.70KForm 4
Oct 1, 2026King-Jones HeidySee RemarksOption exercise28,933$419.53KForm 4
Sep 30, 2026Burrows Scott LChief Financial OfficerSale17,500$1.57MForm 4
Sep 30, 2026Burrows Scott LChief Financial OfficerOption exercise17,500$253.75KForm 4
Sep 2, 2026Burrows Scott LChief Financial OfficerSale18,232$1.63MForm 4
Sep 2, 2026King-Jones HeidySee RemarksSale400$36.00KForm 4
Sep 2, 2026King-Jones HeidySee RemarksOption exercise400$5.80KForm 4
Sep 1, 2026Burrows Scott LChief Financial OfficerSale200$17.81KForm 4
Sep 1, 2026Burrows Scott LChief Financial OfficerSale2,016$177.47KForm 4
Sep 1, 2026Burrows Scott LChief Financial OfficerSale4,384$381.89KForm 4
Sep 1, 2026Burrows Scott LChief Financial OfficerSale900$77.63KForm 4
Sep 1, 2026Burrows Scott LChief Financial OfficerOption exercise7,500$108.75KForm 4
Sep 1, 2026King-Jones HeidySee RemarksSale400$35.75KForm 4
Sep 1, 2026King-Jones HeidySee RemarksSale6,206$547.18KForm 4
Sep 1, 2026King-Jones HeidySee RemarksSale16,548$1.44MForm 4
Sep 1, 2026King-Jones HeidySee RemarksSale4,845$418.61KForm 4
Sep 1, 2026King-Jones HeidySee RemarksOption exercise27,999$405.99KForm 4
Sep 1, 2026Turtle CameronChief Executive OfficerSale400$35.63KForm 4
Sep 1, 2026Turtle CameronChief Executive OfficerSale3,700$325.82KForm 4
Sep 1, 2026Turtle CameronChief Executive OfficerSale8,400$732.06KForm 4
Sep 1, 2026Turtle CameronChief Executive OfficerSale2,500$215.90KForm 4
Aug 7, 2026Albers Jeffrey W.DirectorSale10,000$1.05MForm 4
Aug 7, 2026Albers Jeffrey W.DirectorSale8,000$835.04KForm 4
Aug 7, 2026Albers Jeffrey W.DirectorSale5,000$522.35KForm 4
Aug 7, 2026Albers Jeffrey W.DirectorOption exercise5,000$51.95KForm 4
Aug 3, 2026Turtle CameronChief Executive OfficerSale16$1.56KForm 4
Aug 3, 2026Turtle CameronChief Executive OfficerSale1,392$134.77KForm 4
Aug 3, 2026Turtle CameronChief Executive OfficerSale5,635$540.57KForm 4
Aug 3, 2026Turtle CameronChief Executive OfficerSale7,157$680.63KForm 4
Aug 3, 2026Turtle CameronChief Executive OfficerSale800$75.18KForm 4
Aug 3, 2026Burrows Scott LChief Financial OfficerSale100$9.71KForm 4
Aug 3, 2026Burrows Scott LChief Financial OfficerSale2,300$221.49KForm 4
Aug 3, 2026Burrows Scott LChief Financial OfficerSale5,100$485.57KForm 4
Aug 3, 2026Burrows Scott LChief Financial OfficerOption exercise7,500$108.75KForm 4
Jul 1, 2026Turtle CameronChief Executive OfficerSale590$52.46KForm 4
Jul 1, 2026Turtle CameronChief Executive OfficerSale4,234$373.10KForm 4
Jul 1, 2026Turtle CameronChief Executive OfficerSale10,176$889.79KForm 4
Jul 1, 2026Burrows Scott LChief Financial OfficerSale1,725$152.44KForm 4
Jul 1, 2026Burrows Scott LChief Financial OfficerSale5,775$505.60KForm 4
Jul 1, 2026Burrows Scott LChief Financial OfficerOption exercise7,500$108.75KForm 4
Jul 1, 2026Sloan SheldonChief Medical OfficerSale1,834$162.02KForm 4
Jul 1, 2026Sloan SheldonChief Medical OfficerSale6,500$568.88KForm 4
Jul 1, 2026Sloan SheldonChief Medical OfficerOption exercise8,334$228.85KForm 4
Jun 25, 2026Burrows Scott LChief Financial OfficerSale10,000$871.40KForm 4
Jun 25, 2026Burrows Scott LChief Financial OfficerSale5,000$435.60KForm 4
Jun 25, 2026Burrows Scott LChief Financial OfficerOption exercise15,000$217.50KForm 4
Jun 23, 2026Fairmount Funds Management LLC & Fairmount Healthcare Fund II L.P. & Kiselak Tomas & Harwin Peter EvanDirectorSale4,684,781$399.66MForm 4
Jun 23, 2026Fairmount Funds Management LLC & Fairmount Healthcare Fund II L.P. & Kiselak Tomas & Harwin Peter EvanDirectorConversion666,680—Form 4
Jun 22, 2026HENDERSON MICHAEL THOMASDirectorSale20,000$2.00MForm 4
Jun 3, 2026Sloan SheldonChief Medical OfficerSale8,333$624.98KForm 4
Jun 3, 2026Sloan SheldonChief Medical OfficerOption exercise8,333$228.82KForm 4
Jun 1, 2026Turtle CameronChief Executive OfficerSale3,294$235.13KForm 4
Jun 1, 2026Turtle CameronChief Executive OfficerSale8,149$574.50KForm 4
Jun 1, 2026Turtle CameronChief Executive OfficerSale3,557$246.86KForm 4
Jun 1, 2026Burrows Scott LChief Financial OfficerSale3,100$223.39KForm 4
Jun 1, 2026Burrows Scott LChief Financial OfficerSale2,599$183.93KForm 4
Jun 1, 2026Burrows Scott LChief Financial OfficerSale1,801$125.62KForm 4
Jun 1, 2026Burrows Scott LChief Financial OfficerOption exercise7,500$108.75KForm 4
May 8, 2026HENDERSON MICHAEL THOMASDirectorSale19,269$1.45MForm 4
May 8, 2026HENDERSON MICHAEL THOMASDirectorSale24,814$1.86MForm 4
May 8, 2026HENDERSON MICHAEL THOMASDirectorSale33,513$2.47MForm 4
May 8, 2026HENDERSON MICHAEL THOMASDirectorSale2,404$174.46KForm 4
May 1, 2026Turtle CameronChief Executive OfficerSale300$22.49KForm 4
May 1, 2026Turtle CameronChief Executive OfficerSale1,700$126.19KForm 4
May 1, 2026Turtle CameronChief Executive OfficerSale3,100$226.73KForm 4
May 1, 2026Turtle CameronChief Executive OfficerSale1,000$71.76KForm 4
May 1, 2026Turtle CameronChief Executive OfficerSale3,600$254.77KForm 4
May 1, 2026Turtle CameronChief Executive OfficerSale5,300$368.56KForm 4
May 1, 2026Burrows Scott LChief Financial OfficerSale12,500$892.13KForm 4
May 1, 2026Burrows Scott LChief Financial OfficerOption exercise12,500$181.25KForm 4
May 1, 2026Sloan SheldonChief Medical OfficerSale400$30.15KForm 4
May 1, 2026Sloan SheldonChief Medical OfficerSale5,059$377.40KForm 4
May 1, 2026Sloan SheldonChief Medical OfficerSale10,358$763.80KForm 4
May 1, 2026Sloan SheldonChief Medical OfficerSale12,777$931.95KForm 4
May 1, 2026Sloan SheldonChief Medical OfficerSale8,777$628.08KForm 4
May 1, 2026Sloan SheldonChief Medical OfficerSale19,656$1.39MForm 4
May 1, 2026Sloan SheldonChief Medical OfficerSale21,306$1.48MForm 4
May 1, 2026Sloan SheldonChief Medical OfficerOption exercise78,333$2.15MForm 4
Apr 1, 2026Burrows Scott LChief Financial OfficerSale6,200$305.10KForm 4
Apr 1, 2026Burrows Scott LChief Financial OfficerOption exercise7,500$108.75KForm 4
Apr 1, 2026Sloan SheldonChief Medical OfficerSale7,958$397.90KForm 4
Apr 1, 2026Sloan SheldonChief Medical OfficerOption exercise7,958$172.37KForm 4
Apr 1, 2026Turtle CameronChief Executive OfficerSale2,656$132.59KForm 4
Apr 1, 2026Turtle CameronChief Executive OfficerSale12,344$607.32KForm 4

Transaction codes follow SEC Form 4: P = open-market purchase, S = open-market sale, A = grant or award, M = option exercise, F = shares withheld for taxes. About Form 4

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